Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINF2
  • Mouse genes Serpinf2
  • Rat genes Serpinf2
  • Zfish genes serpinf2a,serpinf2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpinf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002020	protease binding	SERPINF2	IPI	UniProtKB:P00747	Human	PMID:134998
Molecular Function	GO:0002020	protease binding	SERPINF2	IPI	UniProtKB:Q8BIK6	Human	PMID:15853774
Molecular Function	GO:0002020	protease binding	SERPINF2	IPI	UniProtKB:Q12884	Human	PMID:17317851
Molecular Function	GO:0002020	protease binding	SERPINF2	IPI	UniProtKB:P08246	Human	PMID:6980881
Molecular Function	GO:0005515	protein binding	SERPINF2	IPI	UniProtKB:Q92876	Human	PMID:12878203
Molecular Function	GO:0005515	protein binding	SERPINF2	IPI	UniProtKB:Q9UKR3	Human	PMID:14687906
Molecular Function	GO:0042803	protein homodimerization activity	SERPINF2	IPI	UniProtKB:P08697	Human	PMID:134998
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINF2	IDA		Human	PMID:134998
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpinf2	IDA		Rat	PMID:6438828|RGD:1625542
Cellular Component	GO:0072562	blood microparticle	SERPINF2	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	SERPINF2	IDA		Human	PMID:17958745
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINF2	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Serpinf2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Serpinf2	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0070062	extracellular exosome	SERPINF2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	SERPINF2	IDA		Human	PMID:6980881
Cellular Component	GO:0005615	extracellular space	Serpinf2	IDA		Rat	PMID:10423332|RGD:1625538
Cellular Component	GO:0005577	fibrinogen complex	SERPINF2	IDA		Human	PMID:17317851
Biological Process	GO:0048514	blood vessel morphogenesis	Serpinf2	IMP		Mouse	MGI:MGI:4453296|PMID:18436805
Biological Process	GO:0030199	collagen fibril organization	Serpinf2	IMP		Mouse	MGI:MGI:5306295|PMID:17958745
Biological Process	GO:0002034	maintenance of blood vessel diameter homeostasis by renin-angiotensin	Serpinf2	IMP		Mouse	MGI:MGI:4453296|PMID:18436805
Biological Process	GO:0051918	negative regulation of fibrinolysis	SERPINF2	IDA		Human	PMID:134998
Biological Process	GO:0051918	negative regulation of fibrinolysis	Serpinf2	IMP		Rat	PMID:6506034|RGD:1625541
Biological Process	GO:0010757	negative regulation of plasminogen activation	SERPINF2	IDA		Human	PMID:134998
Biological Process	GO:0045597	positive regulation of cell differentiation	SERPINF2	IDA		Human	PMID:20008146
Biological Process	GO:0045597	positive regulation of cell differentiation	Serpinf2	IMP		Mouse	MGI:MGI:4420717|PMID:20008146
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	SERPINF2	IDA		Human	PMID:17958745
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Serpinf2	IMP		Mouse	MGI:MGI:4453296|PMID:18436805
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	SERPINF2	IDA		Human	PMID:20008146
Biological Process	GO:0046330	positive regulation of JNK cascade	SERPINF2	IDA		Human	PMID:20008146
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Serpinf2	IMP		Mouse	MGI:MGI:4453296|PMID:18436805
Biological Process	GO:0051496	positive regulation of stress fiber assembly	SERPINF2	IDA		Human	PMID:20008146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SERPINF2	IDA		Human	PMID:17958745
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Serpinf2	IMP		Mouse	MGI:MGI:5306295|PMID:17958745
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	SERPINF2	IDA		Human	PMID:17958745
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	SERPINF2	IDA		Human	PMID:20008146
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	Serpinf2	IMP		Mouse	MGI:MGI:5306295|PMID:17958745
Biological Process	GO:0010033	response to organic substance	Serpinf2	IEP		Rat	PMID:2438835|RGD:1625540

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern