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Serpinf2
Gene Detail
Symbol

Name
ID
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
MGI:107173
Synonyms
alpha 2 antiplasmin, Pli
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:75431732-75439591 bp, - strand
From VEGA annotation of GRCm38

  7860 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SERPINF2
Protein SuperFamily: serpin
Gene Tree: Serpinf2

Human
homologs
SERPINF2, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5345
neXtProt AC: NX_P08697

Human Synonyms: A2AP, AAP, ALPHA-2-PI, API, PLI

Human Chr (Location): 17p13; chr17:1742807-1755265 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Serpinf2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have an essentially normal phenotype. Spontaneous lysis of blood clots occurs more readily but bleeding times are unaffected.
 
Human Diseases Modeled in Mice Using Serpinf2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Serpinf2 interacts with 110 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process acute-phase response, blood vessel morphogenesis, ...
Component blood microparticle, cell surface, ...
Function peptidase inhibitor activity, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (11)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
RT-PCR 11
cDNA source data(153)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase serpinf2 ; ZFIN serpinf2a    NEW 
Molecular
reagents
All nucleic(161) Genomic(6) cDNA(153) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006204 (Evidence)
Ensembl Gene Model ENSMUSG00000038224 (Evidence)
Entrez Gene 18816 (Evidence)
UniGene 279733
DFCI TC1574898
DoTS DT.101155743, DT.493546, DT.94232817
NIA Mouse Gene Index U033078
PDB 2R9Y
Consensus CDS Project CCDS25046.1
International Mouse Phenotyping Consortium Status Serpinf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006204 VEGA Gene Model | MGI Sequence Detail 7860 C57BL/6J ±  kb
transcript OTTMUST00000013993 VEGA | MGI Sequence Detail 2179 Not Applicable 
polypeptide OTTMUSP00000006499 VEGA | MGI Sequence Detail 491 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014706 alpha-2-antiplasmin
References
(Earliest) J:33360 Menoud PA, et al., The kidney is a major site of alpha(2)-antiplasmin production. J Clin Invest. 1996 Jun 1;97(11):2478-84
(Latest) J:216521 Kawashita E, et al., Altered behavior in mice with deletion of the alpha2-antiplasmin gene. PLoS One. 2014;9(5):e97947
All references(49)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-35634, MGI:2144263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory