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Serpinf2 Gene Detail
Summary
  • Symbol
    Serpinf2
  • Name
    serine (or cysteine) peptidase inhibitor, clade F, member 2
  • Synonyms
    alpha 2 antiplasmin, Pli
  • Feature Type
    protein coding gene
  • IDs
    MGI:107173
    NCBI Gene: 18816
  • Gene Overview
    MyGene.info: SERPINF2
Location & Maps
more
  • Sequence Map
    Chr11:75431732-75439591 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7860 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SERPINF2, serpin family F member 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SERPINF2, serpin family F member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A2AP, AAP, ALPHA-2-PI, API, PLI
  • Links
    NCBI Gene ID: 5345
    neXtProt AC: NX_P08697

  • Chr Location
    17p13.3; chr17:1742807-1755265 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Serpinf2 mouse models; 1 with human SERPINF2 associations

Human Disease Mouse Models
       Alpha-2-Plasmin Inhibitor Deficiency   OMIM: 262850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Serpinf2
  • Incidental Mutations
Mice homozygous for disruptions in this gene have an essentially normal phenotype. Spontaneous lysis of blood clots occurs more readily but bleeding times are unaffected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006204 VEGA Gene Model | MGI Sequence Detail 7860 C57BL/6J ±  kb
transcript OTTMUST00000013993 VEGA | MGI Sequence Detail 2179 Not Applicable  
polypeptide OTTMUSP00000006499 VEGA | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 161
    Genomic 6
    cDNA 153
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35634, MGI:2144263
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:33360 Menoud PA, et al., The kidney is a major site of alpha(2)-antiplasmin production. J Clin Invest. 1996 Jun 1;97(11):2478-84
  • Latest
    J:230677 Byrnes JR, et al., Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin alpha-chain crosslinking. Blood. 2015 Oct 15;126(16):1940-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory