Serpinf2
Gene Detail

Symbol Name ID

Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 MGI:107173

Synonyms

alpha 2 antiplasmin, Pli

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:75431732-75439591 bp, - strand From VEGA annotation of GRCm38   7860 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Serpinf2 ± 2 cM)

Protein SuperFamily: serpin
Gene Tree: Serpinf2

Human ortholog

SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 NCBI Gene ID 5345
Human Synonyms: A2AP, AAP, ALPHA-2-PI, API, PLI
Human Chr17:1646130-1658559 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SERPINF2 (1)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene have an essentially normal phenotype. Spontaneous lysis of blood clots occurs more readily but bleeding times are unaffected.

 
Human Diseases Modeled Using Mouse Serpinf2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	acute-phase response, blood vessel morphogenesis, ...
Component	extracellular region, extracellular space, ...
Function	eukaryotic cell surface binding, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (11)    Images (26)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	25
RT-PCR	11

cDNA source data(152)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(160) Genomic(6) cDNA(152) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006204 (Evidence)
Ensembl Gene Model	ENSMUSG00000038224 (Evidence)
Entrez Gene	18816 (Evidence)
UniGene	279733
DFCI	TC1574898
DoTS	DT.101155743, DT.493546, DT.94232817
NIA Mouse Gene Index	U033078
PDB	2R9Y
Consensus CDS Project	CCDS25046.1
International Mouse Knockout Project Status	Serpinf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006204	VEGA Gene Model | MGI Sequence Detail	7860	C57BL/6J
transcript	OTTMUST00000013993	VEGA | MGI Sequence Detail	2179	Not Applicable
polypeptide	OTTMUSP00000006499	VEGA | MGI Sequence Detail	491	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014706	alpha-2-antiplasmin

References

(Earliest) J:33360 Menoud PA, et al., The kidney is a major site of alpha(2)-antiplasmin production. J Clin Invest. 1996 Jun 1;97(11):2478-84
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)

Other accession IDs

MGD-MRK-35634, MGI:2144263