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Targeted Allele Detail
Symbol: Serpinf2tm1Hrl
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2; targeted mutation 1, H Roger Lijnen
MGI ID: MGI:2181226
Synonyms: alpha-2-AP-, alpha2-AP-
Gene: Serpinf2  Location: Chr11:75322562-75330327 bp, - strand  Genetic Position: Chr11, 45.89 cM
Alliance: Serpinf2tm1Hrl page
Germline Transmission:  Earliest citation of germline transmission: J:54047
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin. (J:43244, J:54047)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpinf2 Mutation:  12 strains or lines available
Original:  J:54047 Lijnen HR, et al., Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood. 1999 Apr 1;93(7):2274-81
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory