Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINA5
  • Mouse genes Serpina5
  • Rat genes Serpina5
  • Zfish genes serpina7,si:ch211-186e20.7,zgc:113828,zgc:174259,zgc:174260
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpina5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032190	acrosin binding	SERPINA5	IPI	UniProtKB:P10323	Human	PMID:7521127
Molecular Function	GO:0031210	phosphatidylcholine binding	SERPINA5	IDA		Human	PMID:9556620
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P00749	Human	PMID:10340997
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P00750	Human	PMID:10340997
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P00749	Human	PMID:14696115
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:Q8BIK6	Human	PMID:15853774
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P07288	Human	PMID:1725227
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P03951	Human	PMID:2844223
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P03952	Human	PMID:2844223
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P12259	Human	PMID:2844223
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P00749	Human	PMID:3501295
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P00734	Human	PMID:6323392
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P00742	Human	PMID:6323392
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P12259	Human	PMID:6323392
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P10323	Human	PMID:7521127
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P07288	Human	PMID:8665956
Molecular Function	GO:0002020	protease binding	SERPINA5	IPI	UniProtKB:P12259	Human	PMID:9556620
Molecular Function	GO:0005515	protein binding	SERPINA5	IPI	UniProtKB:P02751	Human	PMID:24388360
Molecular Function	GO:0005515	protein binding	SERPINA5	IPI	UniProtKB:P10323	Human	PMID:7521127
Molecular Function	GO:0005515	protein binding	SERPINA5	IPI	UniProtKB:P04279	Human	PMID:8665956
Molecular Function	GO:0005515	protein binding	SERPINA5	IPI	UniProtKB:P07288,UniProtKB:Q02383	Human	PMID:8665956
Molecular Function	GO:0005515	protein binding	SERPINA5	IPI	UniProtKB:Q02383	Human	PMID:8665956
Molecular Function	GO:0005515	protein binding	Serpina5	IPI	UniProtKB:Q5S248	Mouse	MGI:MGI:3512862|PMID:15328353
Molecular Function	GO:0001972	retinoic acid binding	SERPINA5	IDA		Human	PMID:11722589
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:10340997
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:15853774
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:1725227
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:2844223
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:3501295
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:6323392
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:7521127
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:8536714
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:9510955
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA5	IDA		Human	PMID:9556620
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpina5	IDA		Rat	PMID:16088033|RGD:1580291
Cellular Component	GO:0002080	acrosomal membrane	SERPINA5	IDA		Human	PMID:7521127
Cellular Component	GO:0002080	acrosomal membrane	SERPINA5	IDA		Human	PMID:9510955
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINA5	HDA		Human	PMID:28327460
Cellular Component	GO:0009897	external side of plasma membrane	SERPINA5	IDA		Human	PMID:9556620
Cellular Component	GO:0070062	extracellular exosome	SERPINA5	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SERPINA5	IDA		Human	PMID:21557262
Cellular Component	GO:0070062	extracellular exosome	SERPINA5	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	SERPINA5	IDA		Human	PMID:10340997
Cellular Component	GO:0005615	extracellular space	SERPINA5	IDA		Human	PMID:1725227
Cellular Component	GO:0005615	extracellular space	SERPINA5	IDA		Human	PMID:8536714
Cellular Component	GO:0005615	extracellular space	SERPINA5	IDA		Human	PMID:8665956
Cellular Component	GO:0016020	membrane	SERPINA5	IDA		Human	PMID:7521127
Cellular Component	GO:0031091	platelet alpha granule	SERPINA5	IDA		Human	PMID:9556620
Cellular Component	GO:0031094	platelet dense tubular network	SERPINA5	IDA		Human	PMID:9556620
Cellular Component	GO:0097181	protein C inhibitor-coagulation factor V complex	SERPINA5	IDA		Human	PMID:6323392
Cellular Component	GO:0097182	protein C inhibitor-coagulation factor Xa complex	SERPINA5	IDA		Human	PMID:6323392
Cellular Component	GO:0097183	protein C inhibitor-coagulation factor XI complex	SERPINA5	IDA		Human	PMID:2844223
Cellular Component	GO:0036029	protein C inhibitor-KLK3 complex	SERPINA5	IDA		Human	PMID:1725227
Cellular Component	GO:0036030	protein C inhibitor-plasma kallikrein complex	SERPINA5	IDA		Human	PMID:2844223
Cellular Component	GO:0036030	protein C inhibitor-plasma kallikrein complex	SERPINA5	IDA		Human	PMID:8536714
Cellular Component	GO:0036026	protein C inhibitor-PLAT complex	SERPINA5	IDA		Human	PMID:10340997
Cellular Component	GO:0036027	protein C inhibitor-PLAU complex	SERPINA5	IDA		Human	PMID:10340997
Cellular Component	GO:0036027	protein C inhibitor-PLAU complex	SERPINA5	IDA		Human	PMID:3501295
Cellular Component	GO:0036027	protein C inhibitor-PLAU complex	SERPINA5	IDA		Human	PMID:8536714
Cellular Component	GO:0036028	protein C inhibitor-thrombin complex	SERPINA5	IDA		Human	PMID:6323392
Cellular Component	GO:0036025	protein C inhibitor-TMPRSS11E complex	SERPINA5	IDA		Human	PMID:15328353
Cellular Component	GO:0036024	protein C inhibitor-TMPRSS7 complex	SERPINA5	IDA		Human	PMID:15853774
Cellular Component	GO:0032991	protein-containing complex	SERPINA5	IDA		Human	PMID:7521127
Cellular Component	GO:0032991	protein-containing complex	SERPINA5	IDA		Human	PMID:8665956
Biological Process	GO:0051346	negative regulation of hydrolase activity	SERPINA5	IMP		Human	PMID:8665956
Biological Process	GO:0045861	negative regulation of proteolysis	Serpina5	IDA		Rat	PMID:16088033|RGD:1580291
Biological Process	GO:0061107	seminal vesicle development	Serpina5	IEP		Rat	PMID:9662429|RGD:633526
Biological Process	GO:0007283	spermatogenesis	Serpina5	IMP		Mouse	MGI:MGI:1928443|PMID:11120760

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern