Serpina5
Gene Detail

Symbol Name ID

Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 MGI:107817

Synonyms

alpha-1 antiproteinase, antitrypsin, PAI-3, Pci

Feature Type

protein coding gene

Genetic Map

Chromosome 12

53.30 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:104101113-104106137 bp, + strand From VEGA annotation of GRCm38   5025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpina5

Human homologs

Human Homolog		SERPINA5, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
NCBI Gene ID		5104
neXtProt AC		NX_P05154
Human Synonyms		PAI3, PAI-3, PCI, PCI-B, PLANH3, PROCI
Human Chr (Location)		14q32.1; chr14:95047706-95059457 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene are phenotypically normal with the exception that males are infertile.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	acrosomal membrane, external side of plasma membrane, ...
Function	acrosin binding, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (60)    Tissues (54)   
Theiler Stages: 13, 15, 17, 19, 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	30
RNA in situ	30

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(3) cDNA(9)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000035419 (Evidence)
Ensembl Gene Model	ENSMUSG00000041550 (Evidence)
Entrez Gene	268591 (Evidence)
UniGene	73172
DFCI	TC1585208
DoTS	DT.60103372
NIA Mouse Gene Index	U014320
Consensus CDS Project	CCDS26146.1
International Mouse Knockout Project Status	Serpina5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035419	VEGA Gene Model | MGI Sequence Detail	5025	C57BL/6J
transcript	OTTMUST00000090570	VEGA | MGI Sequence Detail	2162	Not Applicable
polypeptide	OTTMUSP00000049721	VEGA | MGI Sequence Detail	405	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014685	plasma serine protease inhibitor

References

(Earliest) J:34281 Zechmeister-Machhart M, et al., Molecular cloning and tissue distribution of mouse protein C inhibitor (PCI). Immunopharmacology. 1996 May;32(1-3):96-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Other accession IDs

MGD-MRK-36394