About   Help   FAQ
Serpina5
Gene Detail
Symbol

Name
ID
Serpina5
serine (or cysteine) peptidase inhibitor, clade A, member 5
MGI:107817
Synonyms
alpha-1 antiproteinase, antitrypsin, PAI-3, Pci
Feature Type
protein coding gene
Genetic Map
Chromosome 12
53.30 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:104101113-104106137 bp, + strand
From VEGA annotation of GRCm38

  5025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpina5

Human
homologs
Human Homolog SERPINA5, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
NCBI Gene ID 5104
neXtProt AC  NX_P05154
Human Synonyms  PAI3, PAI-3, PCI, PCI-B, PLANH3, PROCI
Human Chr (Location)  14q32.1; chr14:94581369-94593120 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are phenotypically normal with the exception that males are infertile.
 
Interactions
Serpina5 interacts with 110 markers (Mir22, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (60)    Tissues (54)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 30
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(3) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035419 (Evidence)
Ensembl Gene ModelENSMUSG00000041550 (Evidence)
Entrez Gene268591 (Evidence)
UniGene73172
DFCITC1585208
DoTSDT.60103372
NIA Mouse Gene IndexU014320
Consensus CDS ProjectCCDS26146.1
International Mouse Knockout Project StatusSerpina5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035419 VEGA Gene Model | MGI Sequence Detail 5025 C57BL/6J ±  kb
transcript OTTMUST00000090570 VEGA | MGI Sequence Detail 2162 Not Applicable 
polypeptide OTTMUSP00000049721 VEGA | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014685 plasma serine protease inhibitor
References
(Earliest) J:34281 Zechmeister-Machhart M, et al., Molecular cloning and tissue distribution of mouse protein C inhibitor (PCI). Immunopharmacology. 1996 May;32(1-3):96-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGD-MRK-36394

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory