Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEC63
  • Mouse genes Sec63
  • Rat genes Sec63
  • Zfish genes sec63
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sec63

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SEC63	IPI	UniProtKB:P97346	Human	PMID:21251912
Molecular Function	GO:0005515	protein binding	SEC63	IPI	UniProtKB:Q6FHY5	Human	PMID:26871637
Molecular Function	GO:0003723	RNA binding	SEC63	HDA		Human	PMID:22658674
Cellular Component	GO:0005783	endoplasmic reticulum	SEC63	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	SEC63	IDA		Human	PMID:22375059
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	sec63	IMP	ZFIN:ZDB-GENO-130212-11	Zfish	PMID:22864019
Biological Process	GO:0001889	liver development	Sec63	IMP	MGI:MGI:5442171	Mouse	PMID:21685914
Biological Process	GO:0001889	liver development	Sec63	IGI	MGI:MGI:107877	Mouse	PMID:21685914
Biological Process	GO:0001889	liver development	sec63	IMP	ZFIN:ZDB-MRPHLNO-140116-1	Zfish	PMID:23668934
Biological Process	GO:0042552	myelination	sec63	IMP	ZFIN:ZDB-GENO-130212-11	Zfish	PMID:22864019
Biological Process	GO:0006807	nitrogen compound metabolic process	Sec63	IGI	MGI:MGI:97603	Mouse	PMID:21685914
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	SEC63	IMP		Human	PMID:22375059
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	Sec63	IMP	MGI:MGI:5442171	Mouse	PMID:22375059
Biological Process	GO:0031204	post-translational protein targeting to membrane, translocation	SEC63	IMP		Human	PMID:29719251
Biological Process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SEC63	IMP		Human	PMID:22375059
Biological Process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Sec63	IMP	MGI:MGI:5442171	Mouse	PMID:22375059

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern