About   Help   FAQ
Sec63
Gene Detail
 Symbol
Name
ID
Sec63
SEC63-like (S. cerevisiae)
MGI:2155302
Synonyms 5730478J10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
22.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:42761496-42832514 bp, + strand
From VEGA annotation of GRCm38

  71019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sec63

Human
homologs
Human Homolog SEC63, SEC63 homolog (S. cerevisiae)
NCBI Gene ID 11231
neXtProt AC  NX_Q9UGP8
Human Synonyms  DNAJC23, ERdj2, PRO2507, SEC63L
Human Chr (Location)  6q21; chr6:107867756-107958278 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SEC63
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice homozygous for a conditional allele activated in the kidneys or ubiquitously develop polycystic kidney and liver phenotypes, respectively.
 
Human Diseases Modeled Using Mouse Sec63 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sec63 interacts with 388 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process liver development, multicellular organismal aging, ...
Component cell, endoplasmic reticulum, ...
Function poly(A) RNA binding, protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) Genomic(1) cDNA(118)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000019467 (Evidence)
Ensembl Gene ModelENSMUSG00000019802 (Evidence)
Entrez Gene140740 (Evidence)
UniGene214344
DFCITC1578606, TC1597447, TC1635541, TC1706619
DoTSDT.101289238, DT.110609159, DT.526221, DT.91300291, DT.94174234, DT.94263539, DT.94263542, DT.97361104
NIA Mouse Gene IndexU043063
Consensus CDS ProjectCCDS23815.1
International Mouse Knockout Project StatusSec63
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019467 VEGA Gene Model | MGI Sequence Detail 71019 C57BL/6J ±  kb
transcript OTTMUST00000046488 VEGA | MGI Sequence Detail 6032 Not Applicable 
polypeptide OTTMUSP00000020993 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001623 DnaJ domain
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR004179 Sec63 domain
InterPro IPR027137 Translocation protein Sec63
Protein Ontology PR:000014600 translocation protein SEC63
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197701 Lang S, et al., Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69
All references(38)
Disease annotation references (1)
Other
accession IDs
MGI:1917835, MGI:2143660, MGI:2143832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory