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Sec63
Gene Detail
Symbol

Name
ID
Sec63
SEC63-like (S. cerevisiae)
MGI:2155302
Synonyms
5730478J10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
22.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:42761496-42832514 bp, + strand
From VEGA annotation of GRCm38

  71019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEC63
Gene Tree: Sec63

Human
homologs
SEC63, SEC63 homolog (S. cerevisiae)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11231
neXtProt AC: NX_Q9UGP8

Human Synonyms: DNAJC23, ERdj2, PRO2507, SEC63L

Human Chr (Location): 6q21; chr6:107867756-107958278 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SEC63

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice homozygous for a conditional allele activated in the kidneys or ubiquitously develop polycystic kidney and liver phenotypes, respectively.
 
Human Diseases Modeled in Mice Using Sec63 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sec63 interacts with 387 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process liver development, multicellular organismal aging, ...
Component cell, endoplasmic reticulum, ...
Function poly(A) RNA binding, protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(118)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sec63 ; ZFIN sec63    NEW 
Molecular
reagents
All nucleic(119) Genomic(1) cDNA(118)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000019467 (Evidence)
Ensembl Gene Model ENSMUSG00000019802 (Evidence)
Entrez Gene 140740 (Evidence)
UniGene 214344
DFCI TC1578606, TC1597447, TC1706619, TC1635541
DoTS DT.94174234, DT.91300291, DT.526221, DT.110609159, DT.101289238, DT.94263542, DT.94263539, DT.97361104
NIA Mouse Gene Index U043063
Consensus CDS Project CCDS23815.1
International Mouse Phenotyping Consortium Status Sec63
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019467 VEGA Gene Model | MGI Sequence Detail 71019 C57BL/6J ±  kb
transcript OTTMUST00000046488 VEGA | MGI Sequence Detail 6032 Not Applicable 
polypeptide OTTMUSP00000020993 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001623 DnaJ domain
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR004179 Sec63 domain
InterPro IPR027137 Translocation protein Sec63
Protein Ontology PR:000014600 translocation protein SEC63
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197701 Lang S, et al., Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69
All references(38)
Disease annotation references (1)
Other
accession IDs
MGI:1917835, MGI:2143660, MGI:2143832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory