Sec63
Gene Detail

Symbol Name ID

Sec63 SEC63-like (S. cerevisiae) MGI:2155302

Synonyms

5730478J10Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 10

22.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:42761496-42832514 bp, + strand From VEGA annotation of GRCm38   71019 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sec63

Human homologs

Human Homolog		SEC63, SEC63 homolog (S. cerevisiae)
NCBI Gene ID		11231
neXtProt AC		NX_Q9UGP8
Human Synonyms		DNAJC23, ERdj2, PRO2507, SEC63L
Human Chr (Location)		6q21; chr6:108188960-108279482 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SEC63

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(4)
 

Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice homozygous for a conditional allele activated in the kidneys or ubiquitously develop polycystic kidney and liver phenotypes, respectively.

 
Human Diseases Modeled Using Mouse Sec63 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	liver development, multicellular organismal aging, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	protein transporter activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(121)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(122) Genomic(1) cDNA(121)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000019467 (Evidence)
Ensembl Gene Model	ENSMUSG00000019802 (Evidence)
Entrez Gene	140740 (Evidence)
UniGene	214344
DFCI	TC1578606, TC1597447, TC1635541, TC1706619
DoTS	DT.526221, DT.101289238, DT.110609159, DT.91300291, DT.94174234, DT.94263539, DT.94263542, DT.97361104
NIA Mouse Gene Index	U043063
Consensus CDS Project	CCDS23815.1
International Mouse Knockout Project Status	Sec63

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019467	VEGA Gene Model | MGI Sequence Detail	71019	C57BL/6J
transcript	OTTMUST00000046488	VEGA | MGI Sequence Detail	6032	Not Applicable
polypeptide	OTTMUSP00000020993	VEGA | MGI Sequence Detail	760	Not Applicable

All sequences(62) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(309 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR004179	Sec63 domain
InterPro	IPR027137	Translocation protein Sec63
Protein Ontology	PR:000014600	translocation protein SEC63

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188763 Fedeles SV, et al., A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet. 2011 Jul;43(7):639-47
All references(37)

Other accession IDs

MGI:1917835, MGI:2143660, MGI:2143832