Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCIMP
  • Mouse genes Scimp
  • Rat genes Scimp
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scimp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:P07948	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:P11049	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:P19397	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:P41240	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:P60033	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:P62993	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:Q6ZN84	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:Q8WV28	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	SCIMP	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Scimp	IPI	UniProtKB:P41241|UniProtKB:Q60631|UniProtKB:Q9QUN3	Mouse	MGI:MGI:6317162|PMID:28290451
Molecular Function	GO:0005515	protein binding	Scimp	IPI	UniProtKB:Q60631|UniProtKB:Q9QUN3	Mouse	MGI:MGI:5300118|PMID:21930792
Molecular Function	GO:0005515	protein binding	Scimp	IPI	UniProtKB:P25911|UniProtKB:Q60631|UniProtKB:Q9QUK6	Mouse	MGI:MGI:5913054|PMID:28098138
Cellular Component	GO:0030175	filopodium	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Cellular Component	GO:0001772	immunological synapse	SCIMP	IDA		Human	PMID:21930792
Cellular Component	GO:0031256	leading edge membrane	SCIMP	IDA		Human	PMID:21930792
Cellular Component	GO:0016020	membrane	SCIMP	IDA		Human	PMID:21930792
Cellular Component	GO:0045335	phagocytic vesicle	Scimp	IMP		Mouse	MGI:MGI:5803730|PMID:27288407
Cellular Component	GO:0043235	receptor complex	Scimp	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Cellular Component	GO:0001726	ruffle	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Cellular Component	GO:0097197	tetraspanin-enriched microdomain	SCIMP	IDA		Human	PMID:21930792
Cellular Component	GO:0031259	uropod membrane	SCIMP	IDA		Human	PMID:21930792
Biological Process	GO:0071226	cellular response to molecule of fungal origin	Scimp	IMP		Mouse	MGI:MGI:5803730|PMID:27288407
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	Scimp	IMP		Mouse	MGI:MGI:5803730|PMID:27288407
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	Scimp	IMP		Mouse	MGI:MGI:5803730|PMID:27288407
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	SCIMP	IDA		Human	PMID:21930792
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Scimp	IMP		Mouse	MGI:MGI:5300118|PMID:21930792
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	Scimp	IDA		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Scimp	IMP		Mouse	MGI:MGI:5803730|PMID:27288407
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0034154	toll-like receptor 7 signaling pathway	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138
Biological Process	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	Scimp	IMP		Mouse	MGI:MGI:5913054|PMID:28098138

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern