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Scimp Gene Detail
Summary
  • Symbol
    Scimp
  • Name
    SLP adaptor and CSK interacting membrane protein
  • Synonyms
    A430084P05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3610314
    NCBI Gene: 327957
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70790932-70812561 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3610314
protein coding gene Chr11:70790932-70812586 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018616
protein coding gene Chr11:71353608-71376531 (-)
A/J MGP_AJ_G0018584
protein coding gene Chr11:68648421-68669065 (-)
AKR/J MGP_AKRJ_G0018553
protein coding gene Chr11:70714086-70736236 (-)
BALB/cJ MGP_BALBcJ_G0018556
protein coding gene Chr11:68957883-68966852 (-)
C3H/HeJ MGP_C3HHeJ_G0018369
protein coding gene Chr11:70733197-70741435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019007
protein coding gene Chr11:73517970-73529293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016652
protein coding gene Chr11:65550620-65573211 (-)
CAST/EiJ MGP_CASTEiJ_G0017924
protein coding gene Chr11:70999972-71037445 (-)
CBA/J MGP_CBAJ_G0018341
protein coding gene Chr11:76823432-76835723 (-)
DBA/2J MGP_DBA2J_G0018451
protein coding gene Chr11:68223085-68245603 (-)
FVB/NJ MGP_FVBNJ_G0018441
protein coding gene Chr11:67866418-67888744 (-)
LP/J MGP_LPJ_G0018521
protein coding gene Chr11:71927410-71935703 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018464
protein coding gene Chr11:77374666-77398384 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019049
protein coding gene Chr11:70966920-70989617 (-)
PWK/PhJ MGP_PWKPhJ_G0017698
protein coding gene Chr11:68861610-68887148 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017488
protein coding gene Chr11:70786294-70807379 (-)
WSB/EiJ MGP_WSBEiJ_G0017978
protein coding gene Chr11:70633740-70655971 (-)



Homology
more
  • Human Ortholog
    SCIMP, SLP adaptor and CSK interacting membrane protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SCIMP, SLP adaptor and CSK interacting membrane protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf87, UNQ5783
  • Links
    NCBI Gene ID: 388325
    neXtProt AC: NX_Q6UWF3
    UniProt: Q6UWF3

  • Chr Location
    17p13.2; chr17:5208920-5234860 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are anemic. Male mutants also exhibit increased mean body weight and an increased mean serum cholesterol level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 327957 NCBI Gene Model | MGI Sequence Detail 21630 C57BL/6J ±  kb
transcript NM_001045526 RefSeq | MGI Sequence Detail 1055 C57BL/6  
polypeptide Q3UU41 UniProt | EBI | MGI Sequence Detail 150 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031949 SLP adapter and CSK-interacting membrane protein
  • InterPro Domains
    IPR028181 SLP adapter and CSK-interacting membrane protein
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 1
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:235794 Kralova J, et al., The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells. J Biol Chem. 2016 Aug 5;291(32):16530-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory