Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes S1PR3
  • Mouse genes S1pr3
  • Rat genes S1pr3
  • Zfish genes s1pr3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set S1pr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	S1PR3	IPI	UniProtKB:P16144	Human	PMID:24851274
Molecular Function	GO:0005515	protein binding	S1PR3	IPI	UniProtKB:P16144	Human	PMID:24851274
Molecular Function	GO:0005515	protein binding	S1PR3	IPI	UniProtKB:P06028	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	S1PR3	IPI	UniProtKB:P21964	Human	PMID:32296183
Cellular Component	GO:0005886	plasma membrane	S1PR3	IDA		Human	PMID:24851274
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	S1pr3	IDA		Mouse	PMID:11443127
Biological Process	GO:0001816	cytokine production	S1pr3	IMP	MGI:MGI:2182637	Mouse	PMID:18305483
Biological Process	GO:0006954	inflammatory response	S1pr3	IMP	MGI:MGI:2182637	Mouse	PMID:18305483
Biological Process	GO:1903141	negative regulation of establishment of endothelial barrier	S1PR3	IMP		Human	PMID:24851274
Biological Process	GO:0007219	Notch signaling pathway	S1pr3	IDA		Mouse	PMID:23117660
Biological Process	GO:0032651	regulation of interleukin-1 beta production	S1pr3	IMP	MGI:MGI:2182637	Mouse	PMID:18305483

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern