S1pr3
Gene Detail

Symbol Name ID

S1pr3 sphingosine-1-phosphate receptor 3 MGI:1339365

Synonyms

Edg3, LPb3, S1P3

Feature Type

protein coding gene

Genetic Map

Chromosome 13

26.12 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:51408618-51422797 bp, + strand From NCBI annotation of GRCm38   14180 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr3

Human homologs

Human Homolog		S1PR3, sphingosine-1-phosphate receptor 3
NCBI Gene ID		1903
neXtProt AC		NX_Q99500
Human Synonyms		EDG3, EDG-3, LPB3, S1P3
Human Chr (Location)		9q22.1-q22.2; chr9:91606324-91620070 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced.

 
Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, cytokine production, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (175)    Tissues (145)    Images (26)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	162
RT-PCR	13

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) cDNA(64) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000067586 (Evidence)
Entrez Gene	13610 (Evidence)
UniGene	136736
DFCI	TC1572407
DoTS	DT.101320544
NIA Mouse Gene Index	U014842
Consensus CDS Project	CCDS26512.1
International Mouse Knockout Project Status	S1pr3

Sequences

Length	Strain/Species
genomic	13610	NCBI Gene Model | MGI Sequence Detail	14180	C57BL/6J
transcript	NM_010101	RefSeq | MGI Sequence Detail	4484	C57BL/6
polypeptide	Q9Z0U9	UniProt | EBI | MGI Sequence Detail	378	Not Applicable

All sequences(34) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(134 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004062	EDG-3 sphingosine 1-phosphate receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR004061	Sphingosine 1-phosphate receptor
Protein Ontology	PR:000001708	sphingosine 1-phosphate receptor 3

Graphical View of Protein Domain Structure

References

(Earliest) J:52870 Zhang G, et al., Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 1999 Feb 4;227(1):89-99
(Latest) J:189850 Bajwa A, et al., Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol. 2012 Sep 1;189(5):2584-96
All references(77)

Other accession IDs

MGI:2145186