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S1pr3 Gene Detail
Summary
  • Symbol
    S1pr3
  • Name
    sphingosine-1-phosphate receptor 3
  • Synonyms
    Edg3, LPb3, S1P3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339365
    NCBI Gene: 13610
  • Gene Overview
    MyGene.info: S1PR3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51408639-51422797 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.12 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339365
protein coding gene Chr13:51408618-51422797 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020549
protein coding gene Chr13:50605137-50619295 (+)
A/J MGP_AJ_G0020503
protein coding gene Chr13:48821546-48835721 (+)
AKR/J MGP_AKRJ_G0020481
protein coding gene Chr13:50215985-50230168 (+)
BALB/cJ MGP_BALBcJ_G0020499
protein coding gene Chr13:49017647-49031875 (+)
C3H/HeJ MGP_C3HHeJ_G0020299
protein coding gene Chr13:50045149-50059561 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020933
protein coding gene Chr13:52174708-52188881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018515
protein coding gene Chr13:46624762-46639185 (+)
CAST/EiJ MGP_CASTEiJ_G0019812
protein coding gene Chr13:50003001-50019366 (+)
CBA/J MGP_CBAJ_G0020258
protein coding gene Chr13:54209849-54224030 (+)
DBA/2J MGP_DBA2J_G0020381
protein coding gene Chr13:48391137-48405835 (+)
FVB/NJ MGP_FVBNJ_G0020360
protein coding gene Chr13:47825255-47839633 (+)
LP/J MGP_LPJ_G0020457
protein coding gene Chr13:50877710-50891849 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020389
protein coding gene Chr13:53801124-53815278 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020976
protein coding gene Chr13:49774565-49788728 (+)
PWK/PhJ MGP_PWKPhJ_G0019569
protein coding gene Chr13:48313182-48327472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019396
protein coding gene Chr13:48673596-48705609 (+)
WSB/EiJ MGP_WSBEiJ_G0019874
protein coding gene Chr13:50072041-50087520 (+)



Homology
more
  • Human Ortholog
    S1PR3, sphingosine-1-phosphate receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    S1PR3, sphingosine-1-phosphate receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDG3, EDG-3, LPB3, S1P3
  • Links
    NCBI Gene ID: 1903
    neXtProt AC: NX_Q99500
    UniProt: Q99500

  • Chr Location
    9q22.1; chr9:88991409-89005155 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    6 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067586 Ensembl Gene Model | MGI Sequence Detail 14159 C57BL/6J ±  kb
    transcript ENSMUST00000087978 Ensembl | MGI Sequence Detail 4463 Not Applicable  
    polypeptide ENSMUSP00000085293 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 66
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145186
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 20
      Gene Ontology 6
      Phenotypes 55
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:265045 Hill RZ, et al., S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways. J Neurosci. 2018 Sep 5;38(36):7833-7843

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory