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S1pr3 Gene Detail
Summary
  • Symbol
    S1pr3
  • Name
    sphingosine-1-phosphate receptor 3
  • Synonyms
    Edg3, LPb3, S1P3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339365
    NCBI Gene: 13610
  • Gene Overview
    MyGene.info: S1PR3
Location & Maps
more
  • Sequence Map
    Chr13:51408618-51422797 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14180 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.12 cM, cytoband B1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    S1PR3, sphingosine-1-phosphate receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    S1PR3, sphingosine-1-phosphate receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDG3, EDG-3, LPB3, S1P3
  • Links
    NCBI Gene ID: 1903
    neXtProt AC: NX_Q99500

  • Chr Location
    9q22.1-q22.2; chr9:88991409-89005155 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    6 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving S1pr3
  • Incidental Mutations
Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13610 NCBI Gene Model | MGI Sequence Detail 14180 C57BL/6J ±  kb
transcript NM_010101 RefSeq | MGI Sequence Detail 4484 C57BL/6  
polypeptide Q9Z0U9 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    139 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001708 sphingosine 1-phosphate receptor 3
  • InterPro Domains
    IPR004062 EDG-3 sphingosine 1-phosphate receptor
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR004061 Sphingosine 1-phosphate receptor
Molecular
Reagents
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  • All nucleic 68
    cDNA 65
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGI:2145186
References
more
  • Summaries
    All 87
    Developmental Gene Expression 19
    Gene Ontology 6
    Phenotypes 47
  • Earliest
    J:52870 Zhang G, et al., Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 1999 Feb 4;227(1):89-99
  • Latest
    J:227542 Sanna MG, et al., Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan;89(1):176-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory