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S1pr3
Gene Detail
Symbol

Name
ID
S1pr3
sphingosine-1-phosphate receptor 3
MGI:1339365
Synonyms
Edg3, LPb3, S1P3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
26.12 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:51408618-51422797 bp, + strand
From NCBI annotation of GRCm38

  14180 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: S1PR3
Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr3

Human
homologs
S1PR3, sphingosine-1-phosphate receptor 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1903
neXtProt AC: NX_Q99500

Human Synonyms: EDG3, EDG-3, LPB3, S1P3

Human Chr (Location): 9q22.1-q22.2; chr9:88991409-89005155 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced.
 
Phenotype Images(6)
Interactions
S1pr3 interacts with 284 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (19 records)
Data Summary: Results (262)    Tissues (190)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 249
RT-PCR 13
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase s1pr3 ; ZFIN s1pr3a    NEW 
Molecular
reagents
All nucleic(68) cDNA(65) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000067586 (Evidence)
Entrez Gene 13610 (Evidence)
UniGene 136736
DFCI TC1572407
DoTS DT.101320544
NIA Mouse Gene Index U014842
Consensus CDS Project CCDS26512.1
International Mouse Phenotyping Consortium Status S1pr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13610 NCBI Gene Model | MGI Sequence Detail 14180 C57BL/6J ±  kb
transcript NM_010101 RefSeq | MGI Sequence Detail 4484 C57BL/6 
polypeptide Q9Z0U9 UniProt | EBI | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004062 EDG-3 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001708 sphingosine 1-phosphate receptor 3
Graphical View of Protein Domain Structure
References
(Earliest) J:52870 Zhang G, et al., Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 1999 Feb 4;227(1):89-99
(Latest) J:221525 Murakami K, et al., Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. PLoS One. 2014;9(9):e106792
All references(87)
Other
accession IDs
MGI:2145186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory