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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		S1pr3
sphingosine-1-phosphate receptor 3
MGI:1339365
31 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
S1pr1tm1Rlp/S1pr1tm1Rlp
S1pr3tm1Rlp/S1pr3tm1Rlp
involves: 129S6/SvEvTac * C57BL/6 		abnormal limb morphology J:106055
embryonic lethality during organogenesis, complete penetrance J:106055
hemorrhage J:106055
S1pr1tm1Rlp/S1pr1tm1Rlp
S1pr3tm1Rlp/S1pr3tm1Rlp
S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6 		abnormal angiogenesis J:106055
embryonic lethality during organogenesis, complete penetrance J:106055
hemorrhage J:106055
S1pr2tm1Jch/S1pr2tm1Jch
S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		abnormal inner ear vestibule morphology J:118369
abnormal maternal nurturing J:77809
abnormal posture J:118369
abnormal vestibular system physiology J:118369
absent startle reflex J:118369
absent vestibular hair cell stereocilia J:118369
cochlear ganglion degeneration J:118369
cochlear inner hair cell degeneration J:118369
cochlear outer hair cell degeneration J:118369
decreased litter size J:77809
decreased vertical activity J:118369
degeneration of organ of Corti supporting cells J:118369
head tilt J:118369
impaired righting response J:118369
impaired swimming J:118369
limb grasping J:118369
organ of Corti degeneration J:118369
perinatal lethality, incomplete penetrance J:77809
utricular macular degeneration J:118369
vestibular hair cell degeneration J:118369
vestibular saccular macula degeneration J:118369
S1pr3tm1Jch/S1pr3+
S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		absent startle reflex J:118369
S1pr3tm1Rlp/S1pr3tm1Rlp
S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6 		abnormal vascular endothelial cell morphology J:106055
cochlear ganglion degeneration J:121165
head tilt J:121165
hemorrhage J:106055
increased miscarriage rate J:106055
lethality throughout fetal growth and development, incomplete penetrance J:106055
prenatal lethality, incomplete penetrance J:121165
reduced fertility J:106055
skin edema J:106055
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory