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S1pr1tm1Rlp
Targeted Allele Detail
Summary
Symbol: S1pr1tm1Rlp
Name: sphingosine-1-phosphate receptor 1; targeted mutation 1, Richard L Proia
MGI ID: MGI:2158346
Synonyms: Edg1LacZ, S1P1-, S1P1Ko, S1pr1-, Slp1-LacZ
Gene: S1pr1  Location: Chr3:115504082-115508704 bp, - strand  Genetic Position: Chr3, 50.0 cM
Alliance: S1pr1tm1Rlp page
Bleeding phenotypes of mice carrying different combinations of deleted S1p receptors

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71961
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-lacZ reporter gene and neomycin selection cassette was inserted after codon 42 of the coding region of the gene. RT-PCR analysis demonstrated that the endogenous transcript was not detectable in homozygous embryos. A beta-galactosidase protein was expressed from this allele under the control of the endogenous promoter. (J:71961)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr1 Mutation:  30 strains or lines available
References
Original:  J:71961 Liu Y, et al., Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 2000 Oct;106(8):951-61
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory