Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS6KA6
  • Mouse genes Rps6ka6
  • Rat genes Rps6ka6
  • Zfish genes rps6kal
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6ka6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	RPS6KA6	IPI	UniProtKB:Q7Z698	Human	PMID:32296183
Cellular Component	GO:0001650	fibrillar center	RPS6KA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	RPS6KA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	RPS6KA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RPS6KA6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045202	synapse	Rps6ka6	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Rps6ka6	EXP		Mouse	PMID:25211037
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	RPS6KA6	IMP		Human	PMID:15042092
Biological Process	GO:0045992	negative regulation of embryonic development	Rps6ka6	IDA		Mouse	MGI:MGI:3041939|PMID:15121846
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Rps6ka6	IDA		Mouse	MGI:MGI:3041939|PMID:15121846
Biological Process	GO:2000381	negative regulation of mesoderm development	Rps6ka6	IDA		Mouse	MGI:MGI:3041939|PMID:15121846

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern