| GO term: | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| GO id: | GO:0006978 |
| Definition: | A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. |
| Number of paths to term: | 38 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
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mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processresponse to stimuluscellular response to stimuluscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processresponse to stimuluscellular response to stimuluscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processresponse to stimulusresponse to stresscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processresponse to stimulusresponse to stresscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to DNA damage stimulussignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionsignal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)negative regulation of DNA damage response, signal transduction by p53 class mediatorpositive regulation of DNA damage response, signal transduction by p53 class mediatorregulation of DNA damage response, signal transduction by p53 class mediator +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionsignal transduction in response to DNA damageDNA damage response, signal transduction resulting in transcriptionDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978] (12 genes, 14 annotations)Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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