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Rps6ka6 Gene Detail
Summary
  • Symbol
    Rps6ka6
  • Name
    ribosomal protein S6 kinase polypeptide 6
  • Synonyms
    2610524K04Rik, RSK4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914321
    NCBI Gene: 67071
  • Gene Overview
    MyGene.info: RPS6KA6
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:111388192-111537959 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 48.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    511 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914321
protein coding gene ChrX:111387837-111538097 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036027
protein coding gene ChrX:108101422-108264282 (-)
A/J MGP_AJ_G0036007
protein coding gene ChrX:108000770-108151181 (-)
AKR/J MGP_AKRJ_G0035926
protein coding gene ChrX:111341969-111495811 (-)
BALB/cJ MGP_BALBcJ_G0035998
protein coding gene ChrX:106620949-106783957 (-)
C3H/HeJ MGP_C3HHeJ_G0035704
protein coding gene ChrX:108565665-108718011 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036523
protein coding gene ChrX:111250235-111437376 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033350
protein coding gene ChrX:104793326-104940481 (-)
CAST/EiJ MGP_CASTEiJ_G0034990
protein coding gene ChrX:92485764-92644975 (-)
CBA/J MGP_CBAJ_G0035680
protein coding gene ChrX:114744836-114943209 (-)
DBA/2J MGP_DBA2J_G0035833
protein coding gene ChrX:107136619-107288992 (-)
FVB/NJ MGP_FVBNJ_G0035774
protein coding gene ChrX:106522229-106671128 (-)
LP/J MGP_LPJ_G0035926
protein coding gene ChrX:109001903-109153942 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035805
protein coding gene ChrX:120137383-120290446 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036550
protein coding gene ChrX:107653280-107813632 (-)
PWK/PhJ MGP_PWKPhJ_G0034685
protein coding gene ChrX:90006927-90158133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034515
protein coding gene ChrX:93341024-93489327 (-)
WSB/EiJ MGP_WSBEiJ_G0035128
protein coding gene ChrX:106475676-106628294 (-)



Homology
more
  • Human Ortholog
    RPS6KA6, ribosomal protein S6 kinase A6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPS6KA6, ribosomal protein S6 kinase A6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p90RSK6, PP90RSK4, RSK4, RSK-4, S6K-alpha-6
  • Links
    NCBI Gene ID: 27330
    neXtProt AC: NX_Q9UK32
    UniProt: Q9UK32

  • Chr Location
    Xq21.1; chrX:84058346-84187935 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    23 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele exhibit a possible gastrulation defect, primitive streak and node defects, failure of chorioallantoic fusion, impaired embryo turning, posterior truncation, abnormal heart development, and microcephaly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025665 Ensembl Gene Model | MGI Sequence Detail 149768 C57BL/6J ±  kb
    transcript ENSMUST00000082034 Ensembl | MGI Sequence Detail 4170 Not Applicable  
    polypeptide ENSMUSP00000080694 Ensembl | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:211945 Laugel-Haushalter V, et al., RSK2 is a modulator of craniofacial development. PLoS One. 2014;9(1):e84343

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory