Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ROCK2
  • Mouse genes Rock2
  • Rat genes Rock2
  • Zfish genes rock2a,rock2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rock2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ROCK2	IPI	UniProtKB:P06748	Human	PMID:17015463
Molecular Function	GO:0005515	protein binding	ROCK2	IPI	UniProtKB:Q9UHD1	Human	PMID:20230755
Molecular Function	GO:0005515	protein binding	ROCK2	IPI	UniProtKB:O60674	Human	PMID:30413785
Molecular Function	GO:0005515	protein binding	ROCK2	IPI	UniProtKB:P40763	Human	PMID:30413785
Molecular Function	GO:0005515	protein binding	ROCK2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rock2	IPI	PR:Q99N57	Mouse	PMID:16365167
Molecular Function	GO:0005515	protein binding	Rock2	IPI	PR:Q61937	Mouse	PMID:17015463
Molecular Function	GO:0005515	protein binding	Rock2	IPI	PR:Q0ZLH2	Mouse	PMID:28089576
Molecular Function	GO:0005515	protein binding	Rock2	IPI	UniProtKB:P19105	Rat	PMID:21457715|RGD:8553568
Molecular Function	GO:0005515	protein binding	rock2a	IPI	RefSeq:NP_001124388	Zfish	PMID:19509062
Molecular Function	GO:0004672	protein kinase activity	Rock2	IDA		Mouse	PMID:25959411
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK2	IDA		Human	PMID:16574662
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK2	IDA		Human	PMID:21147781
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK2	IMP		Human	PMID:24305806
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK2	IMP		Human	PMID:29353861
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Rock2	IMP		Mouse	MGI:MGI:6114922|PMID:24305806
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	ROCK2	IMP		Human	PMID:24065547
Molecular Function	GO:0003723	RNA binding	ROCK2	HDA		Human	PMID:22681889
Cellular Component	GO:0005813	centrosome	ROCK2	IDA		Human	PMID:17015463
Cellular Component	GO:0005813	centrosome	Rock2	IDA		Mouse	PMID:17015463
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ROCK2	IDA		Human	PMID:15121898
Cellular Component	GO:0005829	cytosol	ROCK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005576	extracellular region	rock2b	IMP	ZFIN:ZDB-MRPHLNO-110119-3	Zfish	PMID:21098560|ZFIN:ZDB-PUB-101201-10
Cellular Component	GO:0098978	glutamatergic synapse	Rock2	IDA		Mouse	PMID:18718479
Cellular Component	GO:0098978	glutamatergic synapse	Rock2	IMP		Mouse	PMID:18718479
Cellular Component	GO:0005886	plasma membrane	rock2a	IDA		Zfish	PMID:12062050
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rock2	IDA		Mouse	PMID:18718479
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rock2	IMP		Mouse	PMID:18718479
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rock2	IMP		Mouse	PMID:30826947
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rock2	IDA		Mouse	PMID:30826947
Cellular Component	GO:0031616	spindle pole centrosome	Rock2	IDA		Mouse	PMID:17015463
Biological Process	GO:0030036	actin cytoskeleton organization	Rock2	IGI	UniProtKB:P70335	Mouse	MGI:MGI:3513217|PMID:15464581
Biological Process	GO:0030036	actin cytoskeleton organization	Rock2	IGI	MGI:MGI:1930780	Mouse	PMID:16249236
Biological Process	GO:0030036	actin cytoskeleton organization	Rock2	IGI	MGI:MGI:1351655	Mouse	PMID:16249236
Biological Process	GO:0030036	actin cytoskeleton organization	Rock2	IGI	MGI:MGI:107927	Mouse	PMID:16249236
Biological Process	GO:0097746	blood vessel diameter maintenance	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0042074	cell migration involved in gastrulation	rock2a	IMP		Zfish	PMID:12062050
Biological Process	GO:1905145	cellular response to acetylcholine	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0071394	cellular response to testosterone stimulus	ROCK2	IMP		Human	PMID:24065547
Biological Process	GO:0051298	centrosome duplication	ROCK2	IMP		Human	PMID:17015463
Biological Process	GO:0051298	centrosome duplication	Rock2	IMP		Mouse	PMID:17015463
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ROCK2	IGI	UniProtKB:Q13464	Human	PMID:25816133
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ROCK2	IMP		Human	PMID:25816133
Biological Process	GO:0048813	dendrite morphogenesis	Rock2	IGI	MGI:MGI:87860	Mouse	PMID:23365224
Biological Process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	rock2b	IMP	ZFIN:ZDB-MRPHLNO-110119-3	Zfish	PMID:21098560
Biological Process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	rock2b	IMP	ZFIN:ZDB-MRPHLNO-110119-4	Zfish	PMID:21098560
Biological Process	GO:0001837	epithelial to mesenchymal transition	Rock2	IGI	UniProtKB:P70335	Mouse	MGI:MGI:3513217|PMID:15464581
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Rock2	IGI	MGI:MGI:97847	Mouse	PMID:16365167
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Rock2	IGI	MGI:MGI:95484	Mouse	PMID:16365167
Biological Process	GO:0003007	heart morphogenesis	rock2a	IMP	ZFIN:ZDB-MRPHLNO-181113-3	Zfish	PMID:30030370
Biological Process	GO:0003007	heart morphogenesis	rock2b	IMP	ZFIN:ZDB-MRPHLNO-181113-4	Zfish	PMID:30030370
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ROCK2	IMP		Human	PMID:25816133
Biological Process	GO:0070121	Kupffer's vesicle development	rock2b	IMP	ZFIN:ZDB-MRPHLNO-110119-4	Zfish	PMID:21098560
Biological Process	GO:0070121	Kupffer's vesicle development	rock2b	IMP	ZFIN:ZDB-MRPHLNO-110119-3	Zfish	PMID:21098560
Biological Process	GO:0060031	mediolateral intercalation	rock2a	IMP		Zfish	PMID:12062050
Biological Process	GO:0048333	mesodermal cell differentiation	rock2a	IGI	ZFIN:ZDB-GENE-030115-3,ZFIN:ZDB-GENE-990630-10	Zfish	PMID:19509062
Biological Process	GO:0048333	mesodermal cell differentiation	rock2a	IGI	ZFIN:ZDB-GENE-030115-3,ZFIN:ZDB-GENE-070117-2418	Zfish	PMID:19509062
Biological Process	GO:0044788	modulation by host of viral process	ROCK2	IMP		Human	PMID:19376974
Biological Process	GO:0061157	mRNA destabilization	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0016525	negative regulation of angiogenesis	ROCK2	IMP		Human	PMID:19181962
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly	ROCK2	IGI	UniProtKB:Q13464	Human	PMID:25816133
Biological Process	GO:0010629	negative regulation of gene expression	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ROCK2	IGI	UniProtKB:Q13464	Human	PMID:25816133
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ROCK2	IMP		Human	PMID:25816133
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ROCK2	IMP		Human	PMID:29353861
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0150033	negative regulation of protein localization to lysosome	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:0001843	neural tube closure	Rock2	IGI	MGI:MGI:2135272	Mouse	PMID:17229766
Biological Process	GO:0001843	neural tube closure	Rock2	IGI	MGI:MGI:1100883	Mouse	PMID:17229766
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Rock2	IMP		Mouse	MGI:MGI:6114922|PMID:24305806
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ROCK2	IMP		Human	PMID:29353861
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0060775	planar cell polarity pathway involved in gastrula mediolateral intercalation	rock2a	IMP		Zfish	PMID:12062050
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	Rock2	IMP		Mouse	MGI:MGI:6114922|PMID:24305806
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Rock2	IMP		Mouse	MGI:MGI:6114922|PMID:24305806
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Rock2	IMP		Mouse	MGI:MGI:6114922|PMID:24305806
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Rock2	IMP		Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Rock2	IMP		Rat	PMID:28679962|RGD:13601991
Biological Process	GO:0030335	positive regulation of cell migration	ROCK2	IMP		Human	PMID:20232393
Biological Process	GO:0010825	positive regulation of centrosome duplication	Rock2	IMP		Mouse	PMID:17015463
Biological Process	GO:0032723	positive regulation of connective tissue growth factor production	Rock2	IMP		Rat	PMID:28679962|RGD:13601991
Biological Process	GO:1905205	positive regulation of connective tissue replacement	Rock2	IMP		Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:1905205	positive regulation of connective tissue replacement	Rock2	IMP		Rat	PMID:28679962|RGD:13601991
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ROCK2	IMP		Human	PMID:24065547
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	Rock2	IMP		Rat	PMID:28679962|RGD:13601991
Biological Process	GO:0010628	positive regulation of gene expression	ROCK2	IMP		Human	PMID:24065547
Biological Process	GO:0010628	positive regulation of gene expression	Rock2	IMP		Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:0010628	positive regulation of gene expression	Rock2	IMP		Rat	PMID:28679962|RGD:13601991
Biological Process	GO:0043410	positive regulation of MAPK cascade	Rock2	IMP		Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	ROCK2	IMP		Human	PMID:24305806
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ROCK2	IMP		Human	PMID:24065547
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ROCK2	IMP		Human	PMID:20232393
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	Rock2	IDA		Mouse	PMID:18718479
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	Rock2	IMP		Mouse	PMID:18718479
Biological Process	GO:0030163	protein catabolic process	rock2a	IPI	RefSeq:NP_001124388	Zfish	PMID:19509062
Biological Process	GO:0030163	protein catabolic process	rock2a	IPI	RefSeq:NP_004293	Zfish	PMID:19509062
Biological Process	GO:0007039	protein catabolic process in the vacuole	rock2a	IPI	RefSeq:NP_001124388	Zfish	PMID:19509062
Biological Process	GO:0072659	protein localization to plasma membrane	ROCK2	IGI	UniProtKB:Q13464	Human	PMID:25816133
Biological Process	GO:0072659	protein localization to plasma membrane	ROCK2	IMP		Human	PMID:25816133
Biological Process	GO:0006468	protein phosphorylation	ROCK2	IDA		Human	PMID:18559669
Biological Process	GO:0006468	protein phosphorylation	Rock2	IMP		Mouse	PMID:18524939
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	rock2a	IMP		Zfish	PMID:23201782
Biological Process	GO:0110061	regulation of angiotensin-activated signaling pathway	Rock2	IMP		Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:1900037	regulation of cellular response to hypoxia	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0042752	regulation of circadian rhythm	Rock2	IMP		Mouse	MGI:MGI:5567901|PMID:23172836
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ROCK2	IGI	UniProtKB:Q13464	Human	PMID:25816133
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ROCK2	IMP		Human	PMID:25816133
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ROCK2	IMP		Human	PMID:19997641
Biological Process	GO:0031644	regulation of nervous system process	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0051246	regulation of protein metabolic process	Rock2	IMP		Mouse	MGI:MGI:6114922|PMID:24305806
Biological Process	GO:0090128	regulation of synapse maturation	Rock2	IDA		Mouse	PMID:30826947
Biological Process	GO:0090128	regulation of synapse maturation	Rock2	IMP		Mouse	PMID:30826947
Biological Process	GO:1990776	response to angiotensin	Rock2	IGI	UniProtKB:P70335	Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:0002931	response to ischemia	Rock2	IMP		Mouse	MGI:MGI:6271078|PMID:29353861
Biological Process	GO:0071559	response to transforming growth factor beta	Rock2	IGI	UniProtKB:P70335	Mouse	MGI:MGI:6158813|PMID:28679962
Biological Process	GO:0071559	response to transforming growth factor beta	Rock2	IGI	UniProtKB:Q63644	Rat	PMID:28679962|RGD:13601991
Biological Process	GO:0007266	Rho protein signal transduction	Rock2	IMP		Rat	PMID:18332105|RGD:8554725
Biological Process	GO:0016055	Wnt signaling pathway	rock2a	IMP		Zfish	PMID:12062050

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern