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Gene Ontology Browser
Term Detail
GO term:epithelial to mesenchymal transition
Synonym: EMT
Synonym: epithelial-mesenchymal transition
Synonym: mesenchymal cell differentiation from epithelial cell
GO id:GO:0001837
Definition:A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
Number of paths to term: 12

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amesenchymal cell differentiation
                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                is-acardiac epithelial to mesenchymal transition +
                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                is-aepicardial cell to mesenchymal cell transition
                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                is-aneural crest formation +
                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                        part-ofmesenchymal cell development +
                                                        is-amesenchymal cell differentiation involved in bone development
                                                        is-amesenchymal cell differentiation involved in lung development
                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                        part-ofmesenchymal cell fate commitment
                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-aanimal organ development
                                        part-ofmesenchyme development
                                                part-ofmesenchymal cell differentiation
                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                is-acardiac epithelial to mesenchymal transition +
                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                is-aepicardial cell to mesenchymal cell transition
                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                is-aneural crest formation +
                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                        part-ofmesenchymal cell development +
                                                        is-amesenchymal cell differentiation involved in bone development
                                                        is-amesenchymal cell differentiation involved in lung development
                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                        part-ofmesenchymal cell fate commitment
                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        part-ofmesenchyme development
                                                                part-ofmesenchymal cell differentiation
                                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                                is-acardiac epithelial to mesenchymal transition +
                                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                                is-aepicardial cell to mesenchymal cell transition
                                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                                is-aneural crest formation +
                                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                                        part-ofmesenchymal cell development +
                                                                        is-amesenchymal cell differentiation involved in bone development
                                                                        is-amesenchymal cell differentiation involved in lung development
                                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                                        part-ofmesenchymal cell fate commitment
                                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        part-ofanimal organ development
                                                part-ofmesenchyme development
                                                        part-ofmesenchymal cell differentiation
                                                                is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                        is-acardiac epithelial to mesenchymal transition +
                                                                        is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                        is-aepicardial cell to mesenchymal cell transition
                                                                        is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                        negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                        is-aneural crest formation +
                                                                        positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                        regulatesregulation of epithelial to mesenchymal transition +
                                                                part-ofmesenchymal cell development +
                                                                is-amesenchymal cell differentiation involved in bone development
                                                                is-amesenchymal cell differentiation involved in lung development
                                                                is-amesenchymal cell differentiation involved in mammary gland development
                                                                is-amesenchymal cell differentiation involved in renal system development +
                                                                is-amesenchymal cell differentiation involved in salivary gland development
                                                                part-ofmesenchymal cell fate commitment
                                                                is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-atissue development
                                        is-amesenchyme development
                                                part-ofmesenchymal cell differentiation
                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                is-acardiac epithelial to mesenchymal transition +
                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                is-aepicardial cell to mesenchymal cell transition
                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                is-aneural crest formation +
                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                        part-ofmesenchymal cell development +
                                                        is-amesenchymal cell differentiation involved in bone development
                                                        is-amesenchymal cell differentiation involved in lung development
                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                        part-ofmesenchymal cell fate commitment
                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amesenchymal cell differentiation
                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                is-acardiac epithelial to mesenchymal transition +
                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                is-aepicardial cell to mesenchymal cell transition
                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                is-aneural crest formation +
                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                        part-ofmesenchymal cell development +
                                                        is-amesenchymal cell differentiation involved in bone development
                                                        is-amesenchymal cell differentiation involved in lung development
                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                        part-ofmesenchymal cell fate commitment
                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        part-ofmesenchyme development
                                                                part-ofmesenchymal cell differentiation
                                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                                is-acardiac epithelial to mesenchymal transition +
                                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                                is-aepicardial cell to mesenchymal cell transition
                                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                                is-aneural crest formation +
                                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                                        part-ofmesenchymal cell development +
                                                                        is-amesenchymal cell differentiation involved in bone development
                                                                        is-amesenchymal cell differentiation involved in lung development
                                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                                        part-ofmesenchymal cell fate commitment
                                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        part-ofmesenchyme development
                                                                part-ofmesenchymal cell differentiation
                                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                                is-acardiac epithelial to mesenchymal transition +
                                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                                is-aepicardial cell to mesenchymal cell transition
                                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                                is-aneural crest formation +
                                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                                        part-ofmesenchymal cell development +
                                                                        is-amesenchymal cell differentiation involved in bone development
                                                                        is-amesenchymal cell differentiation involved in lung development
                                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                                        part-ofmesenchymal cell fate commitment
                                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        part-ofmesenchyme development
                                                                part-ofmesenchymal cell differentiation
                                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                                is-acardiac epithelial to mesenchymal transition +
                                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                                is-aepicardial cell to mesenchymal cell transition
                                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                                is-aneural crest formation +
                                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                                        part-ofmesenchymal cell development +
                                                                        is-amesenchymal cell differentiation involved in bone development
                                                                        is-amesenchymal cell differentiation involved in lung development
                                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                                        part-ofmesenchymal cell fate commitment
                                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amesenchymal cell differentiation
                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                is-acardiac epithelial to mesenchymal transition +
                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                is-aepicardial cell to mesenchymal cell transition
                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                is-aneural crest formation +
                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                        part-ofmesenchymal cell development +
                                                        is-amesenchymal cell differentiation involved in bone development
                                                        is-amesenchymal cell differentiation involved in lung development
                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                        part-ofmesenchymal cell fate commitment
                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amesenchymal cell differentiation
                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                is-acardiac epithelial to mesenchymal transition +
                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                is-aepicardial cell to mesenchymal cell transition
                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                is-aneural crest formation +
                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                        part-ofmesenchymal cell development +
                                                        is-amesenchymal cell differentiation involved in bone development
                                                        is-amesenchymal cell differentiation involved in lung development
                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                        part-ofmesenchymal cell fate commitment
                                                        is-aneural crest cell differentiation +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organism development
                                        part-ofsystem development
                                                part-ofanimal organ development
                                                        part-ofmesenchyme development
                                                                part-ofmesenchymal cell differentiation
                                                                        is-aepithelial to mesenchymal transition [GO:0001837] (111 genes, 163 annotations)
                                                                                is-acardiac epithelial to mesenchymal transition +
                                                                                is-aclearance of cells from fusion plate by epithelial to mesenchymal transition
                                                                                is-aepicardial cell to mesenchymal cell transition
                                                                                is-amesodermal to mesenchymal transition involved in gastrulation +
                                                                                negatively-regulatesnegative regulation of epithelial to mesenchymal transition +
                                                                                is-aneural crest formation +
                                                                                positively-regulatespositive regulation of epithelial to mesenchymal transition +
                                                                                regulatesregulation of epithelial to mesenchymal transition +
                                                                        part-ofmesenchymal cell development +
                                                                        is-amesenchymal cell differentiation involved in bone development
                                                                        is-amesenchymal cell differentiation involved in lung development
                                                                        is-amesenchymal cell differentiation involved in mammary gland development
                                                                        is-amesenchymal cell differentiation involved in renal system development +
                                                                        is-amesenchymal cell differentiation involved in salivary gland development
                                                                        part-ofmesenchymal cell fate commitment
                                                                        is-aneural crest cell differentiation +


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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory