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Rock2 Gene Detail
Summary
  • Symbol
    Rock2
  • Name
    Rho-associated coiled-coil containing protein kinase 2
  • Synonyms
    B230113H15Rik, Rho-kinase, Rock2m, Rock-II, ROKalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:107926
    NCBI Gene: 19878
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:16894895-16987823 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.04 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    609 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107926
protein coding gene Chr12:16894895-16988274 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019613
protein coding gene Chr12:14300107-14395162 (+)
A/J MGP_AJ_G0019580
protein coding gene Chr12:13800353-13894653 (+)
AKR/J MGP_AKRJ_G0019550
protein coding gene Chr12:14455779-14548614 (+)
BALB/cJ MGP_BALBcJ_G0019556
protein coding gene Chr12:14047158-14139974 (+)
C3H/HeJ MGP_C3HHeJ_G0019361
protein coding gene Chr12:14360965-14460430 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020004
protein coding gene Chr12:14775491-14882280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017630
protein coding gene Chr12:13305779-13399973 (+)
CAST/EiJ MGP_CASTEiJ_G0018916
protein coding gene Chr12:14244657-14344025 (+)
CBA/J MGP_CBAJ_G0019332
protein coding gene Chr12:15583561-15681772 (+)
DBA/2J MGP_DBA2J_G0019445
protein coding gene Chr12:13715282-13811671 (+)
FVB/NJ MGP_FVBNJ_G0019436
protein coding gene Chr12:13603877-13699183 (+)
LP/J MGP_LPJ_G0019516
protein coding gene Chr12:14419382-14515249 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019471
protein coding gene Chr12:15463891-15568125 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020043
protein coding gene Chr12:14142446-14237379 (+)
PWK/PhJ MGP_PWKPhJ_G0018682
protein coding gene Chr12:13753761-13849428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018472
protein coding gene Chr12:14352707-14446508 (+)
WSB/EiJ MGP_WSBEiJ_G0018967
protein coding gene Chr12:14256412-14358866 (+)



Homology
more
  • Human Ortholog
    ROCK2, Rho associated coiled-coil containing protein kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROCK2, Rho associated coiled-coil containing protein kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ROCK-II
  • Links
    NCBI Gene ID: 9475
    neXtProt AC: NX_O75116
    UniProt: O75116

  • Chr Location
    2p25.1; chr2:11179759-11345407 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 6 alleles in 7 genetic backgrounds
    25 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this genes tend to die before birth; those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020580 Ensembl Gene Model | MGI Sequence Detail 92929 C57BL/6J ±  kb
    transcript ENSMUST00000220688 Ensembl | MGI Sequence Detail 4357 Not Applicable  
    polypeptide ENSMUSP00000152813 Ensembl | MGI Sequence Detail 1444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 193
      cDNA 187
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36506, MGI:1925098
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 17
      Phenotypes 32
    • Earliest
      J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
    • Latest
      J:265781 Sunamura S, et al., Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7129-E7138

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory