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Rock2 Gene Detail
Summary
  • Symbol
    Rock2
  • Name
    Rho-associated coiled-coil containing protein kinase 2
  • Synonyms
    B230113H15Rik, Rho-kinase, Rock2m, Rock-II, ROKalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:107926
    NCBI Gene: 19878
Location & Maps
more
  • Sequence Map
    Chr12:16894978-16988274 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      93297 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ROCK2, Rho associated coiled-coil containing protein kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROCK2, Rho associated coiled-coil containing protein kinase 2
    Orthology source: HomoloGene
  • Synonyms
    ROCK-II
  • Links
    NCBI Gene ID: 9475
    neXtProt AC: NX_O75116

  • Chr Location
    2p24; chr2:11179764-11345363 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this genes tend to die before birth; those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19878 NCBI Gene Model | MGI Sequence Detail 93297 C57BL/6J ±  kb
transcript NM_009072 RefSeq | MGI Sequence Detail 8012 C57BL/6  
polypeptide P70336 UniProt | EBI | MGI Sequence Detail 1388 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    613 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 192
    cDNA 186
    Primer pair 6

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36506, MGI:1925098
References
more
  • Summaries
    All 98
    Developmental Gene Expression 22
    Gene Ontology 12
    Phenotypes 21
  • Earliest
    J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
  • Latest
    J:229442 Kumper S, et al., Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory