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Rock2
Gene Detail
Symbol

Name
ID
Rock2
Rho-associated coiled-coil containing protein kinase 2
MGI:107926
Synonyms
B230113H15Rik, Rho-kinase, Rock2m, Rock-II, ROKalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.04 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:16894978-16988274 bp, + strand
From NCBI annotation of GRCm38

  93297 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ROCK2
Protein SuperFamily: Rho-associated protein kinase
Gene Tree: Rock2

Human
homologs
ROCK2, Rho-associated, coiled-coil containing protein kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9475
neXtProt AC: NX_O75116

Human Synonyms: ROCK-II

Human Chr (Location): 2p24; chr2:11179764-11345363 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this genes tend to die before birth those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults.
 
Interactions
Rock2 interacts with 427 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process actin cytoskeleton organization, cellular response to testosterone stimulus, ...
Component centrosome, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (72)    Tissues (59)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 58
Western blot 6
RT-PCR 3
cDNA source data(184)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rock2 ; ZFIN rock2a, rock2b    NEW 
Molecular
reagents
All nucleic(186) cDNA(185) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000020580 (Evidence)
Entrez Gene 19878 (Evidence)
UniGene 276024
DFCI TC1624251
NIA Mouse Gene Index U013790
EC 2.7.11.1
Consensus CDS Project CCDS36410.1
International Mouse Phenotyping Consortium Status Rock2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19878 NCBI Gene Model | MGI Sequence Detail 93297 C57BL/6J ±  kb
transcript NM_009072 RefSeq | MGI Sequence Detail 8012 C57BL/6 
polypeptide P70336 UniProt | EBI | MGI Sequence Detail 1388 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(624 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR011072 HR1 rho-binding repeat
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR011009 Protein kinase-like domain
InterPro IPR020684 Rho-associated protein kinase
InterPro IPR015008 Rho binding domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000121 rho-associated protein kinase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
(Latest) J:214784 Fusella F, et al., Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. J Pathol. 2014 Oct;234(2):152-63
All references(94)
Other
accession IDs
MGD-MRK-36506, MGI:1925098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory