About   Help   FAQ
Rock2
Gene Detail
Symbol

Name
ID
Rock2
Rho-associated coiled-coil containing protein kinase 2
MGI:107926
Synonyms
B230113H15Rik, Rho-kinase, Rock2m, Rock-II, ROKalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.04 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:16894978-16988274 bp, + strand
From NCBI annotation of GRCm38

  93297 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Rho-associated protein kinase
Gene Tree: Rock2

Human
homologs
Human Homolog ROCK2, Rho-associated, coiled-coil containing protein kinase 2
NCBI Gene ID 9475
neXtProt AC  NX_O75116
Human Synonyms  ROCK-II
Human Chr (Location)  2p24; chr2:11179768-11344585 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this genes tend to die before birth those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults.
 
Interactions
Rock2 interacts with 428 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process actin cytoskeleton organization, centrosome duplication, ...
Component centrosome, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (72)    Tissues (59)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 58
Western blot 6
RT-PCR 3
cDNA source data(184)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(186) cDNA(185) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000020580 (Evidence)
Entrez Gene19878 (Evidence)
UniGene276024
DFCITC1624251
NIA Mouse Gene IndexU013790
EC2.7.11.1
Consensus CDS ProjectCCDS36410.1
International Mouse Knockout Project StatusRock2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19878 NCBI Gene Model | MGI Sequence Detail 93297 C57BL/6J ±  kb
transcript NM_009072 RefSeq | MGI Sequence Detail 8012 C57BL/6 
polypeptide P70336 UniProt | EBI | MGI Sequence Detail 1388 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(10) UniProt(13)
Polymorphisms
SNPs within 2kb(624 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR011072 HR1 rho-binding repeat
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR011009 Protein kinase-like domain
InterPro IPR020684 Rho-associated protein kinase
InterPro IPR015008 Rho binding domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000121 rho-associated protein kinase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
(Latest) J:210279 Yao L, et al., Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout. Cardiovasc Res. 2013 Mar 1;97(3):509-19
All references(91)
Other
accession IDs
MGD-MRK-36506, MGI:1925098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory