Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rnf4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RNF4
- Mouse genes Rnf4
- Rat genes Rnf4
- Zfish genes rnf4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rnf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Rnf4	IDA		Rat	PMID:11319220\|RGD:8554033
Molecular Function	GO:0042802	identical protein binding	RNF4	IPI	UniProtKB:P78317	Human	PMID:24714598
Molecular Function	GO:0042802	identical protein binding	Rnf4	IPI	RGD:3583	Rat	PMID:21857666\|RGD:9831417
Molecular Function	GO:0042802	identical protein binding	Rnf4	IPI	UniProtKB:O88846	Rat	PMID:21857666\|RGD:9831417
Molecular Function	GO:0050681	nuclear androgen receptor binding	Rnf4	IPI	RGD:2147	Rat	PMID:9710597\|RGD:69969
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Rnf4	IPI	RGD:10551	Rat	PMID:9710597\|RGD:69969
Molecular Function	GO:0033142	nuclear progesterone receptor binding	Rnf4	IPI	RGD:731081	Rat	PMID:9710597\|RGD:69969
Molecular Function	GO:0031491	nucleosome binding	Rnf4	IDA		Rat	PMID:11319220\|RGD:8554033
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9HBE1	Human	PMID:10713105
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9UHF7	Human	PMID:12885770
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q92674	Human	PMID:20212317
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O75626	Human	PMID:28842558
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:A6NKF2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:B2RXH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O00148	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O00463	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O00635	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O14633	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O15381-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O43805	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O60232	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O60812	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O75344	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O75360	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O75971-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P07910	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P11474	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P13500	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P15336	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P16220	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P17661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P20839-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P22234	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P31943	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P32856-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P35711-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P57721-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P60709	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P61978-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P63165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P78364	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q02040	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q06455-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q07817	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q12846	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q13114	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q13158	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q13422-7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q13554-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q13557-8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q13838	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q15645	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q15916	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q16623	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q3KQV3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5T752	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5T753	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5T754	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5T7P3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5TA77	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5TA81	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5TA82	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q5TCM9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q6ICB0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q8IZU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q8NCN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q8WUN7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q92734	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q96B23	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q96IK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q96K80	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q96MM3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q99801	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q99836	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9BQY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9BS40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9BUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9H0C5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9H7X3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9HAN9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9HCK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9NP64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9NSD4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9NVV9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9NWQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9NWS6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9P2F9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9UER7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9UH03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9UQR0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9Y281	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:Q9Y2F9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF4	IPI	UniProtKB:P63165	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Rnf4	IPI	UniProtKB:Q925H1	Mouse	MGI:MGI:4839455\|PMID:12885770
Molecular Function	GO:0005515	protein binding	Rnf4	IPI	PR:P56916	Mouse	PMID:10822263
Molecular Function	GO:0005515	protein binding	Rnf4	IPI	UniProtKB:P27695	Rat	PMID:20696907\|RGD:13432251
Molecular Function	GO:0005515	protein binding	Rnf4	IPI	UniProtKB:Q13569	Rat	PMID:20696907\|RGD:13432251
Molecular Function	GO:0005515	protein binding	Rnf4	IPI	UniProtKB:P61956	Rat	PMID:21252943\|RGD:8554150
Molecular Function	GO:0005515	protein binding	Rnf4	IPI	UniProtKB:P51668	Rat	PMID:21857666\|RGD:9831417
Molecular Function	GO:0032184	SUMO polymer binding	RNF4	IDA		Human	PMID:35013556
Molecular Function	GO:0032184	SUMO polymer binding	Rnf4	IDA		Rat	PMID:18408734\|RGD:8553731
Molecular Function	GO:0032184	SUMO polymer binding	Rnf4	IPI	UniProtKB:P61956	Rat	PMID:18408734\|RGD:8553731
Molecular Function	GO:0032184	SUMO polymer binding	Rnf4	IPI	UniProtKB:P63165	Rat	PMID:18408734\|RGD:8553731
Molecular Function	GO:0017025	TBP-class protein binding	Rnf4	IDA		Rat	PMID:9710597\|RGD:69969
Molecular Function	GO:0008134	transcription factor binding	Rnf4	IPI	PR:Q9EPQ8-2	Mouse	PMID:10849425
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	Rnf4	IPI	RGD:1317341	Rat	PMID:21857666\|RGD:9831417
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RNF4	IDA		Human	PMID:35013556
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rnf4	IDA		Rat	PMID:21857666\|RGD:9831417
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rnf4	IMP		Rat	PMID:14987998\|RGD:8554770
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rnf4	IDA		Rat	PMID:18408734\|RGD:8553731
Molecular Function	GO:0008270	zinc ion binding	Rnf4	IDA		Rat	PMID:21857666\|RGD:9831417
Cellular Component	GO:0005737	cytoplasm	RNF4	IDA		Human	PMID:12885770
Cellular Component	GO:0005737	cytoplasm	Rnf4	IDA		Mouse	PMID:10822263
Cellular Component	GO:0005829	cytosol	Rnf4	IDA		Rat	PMID:7636430\|RGD:9831412
Cellular Component	GO:1990752	microtubule end	RNF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	RNF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RNF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Rnf4	IDA		Rat	PMID:20943951\|RGD:8553289
Cellular Component	GO:0005634	nucleus	RNF4	IDA		Human	PMID:12885770
Cellular Component	GO:0005634	nucleus	Rnf4	IDA		Mouse	PMID:10822263
Cellular Component	GO:0005634	nucleus	Rnf4	IDA		Mouse	PMID:10849425
Cellular Component	GO:0005634	nucleus	Rnf4	IDA		Rat	PMID:11319220\|RGD:8554033
Cellular Component	GO:0005634	nucleus	Rnf4	IDA		Rat	PMID:9710597\|RGD:69969
Cellular Component	GO:0016605	PML body	RNF4	IDA		Human	PMID:20943951
Cellular Component	GO:0016605	PML body	Rnf4	IDA		Rat	PMID:20943951\|RGD:8553289
Biological Process	GO:0071243	cellular response to arsenic-containing substance	Rnf4	IEP		Rat	PMID:20943951\|RGD:8553289
Biological Process	GO:0071345	cellular response to cytokine stimulus	Rnf4	IEP		Rat	PMID:11292317\|RGD:9831418
Biological Process	GO:0071480	cellular response to gamma radiation	Rnf4	IMP		Rat	PMID:22661230\|RGD:9480235
Biological Process	GO:0072711	cellular response to hydroxyurea	Rnf4	IMP		Rat	PMID:22661230\|RGD:9480235
Biological Process	GO:0071394	cellular response to testosterone stimulus	Rnf4	IDA		Rat	PMID:9710597\|RGD:69969
Biological Process	GO:0030851	granulocyte differentiation	rnf4	IGI	ZFIN:ZDB-GENE-990714-15	Zfish	PMID:29634367
Biological Process	GO:0030851	granulocyte differentiation	rnf4	IMP	ZFIN:ZDB-GENO-190618-8	Zfish	PMID:29634367
Biological Process	GO:0008584	male gonad development	Rnf4	IEP		Rat	PMID:12351196\|RGD:9831411
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	RNF4	IDA		Human	PMID:35013556
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rnf4	IDA		Rat	PMID:11319220\|RGD:8554033
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RNF4	IDA		Human	PMID:12885770
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rnf4	IDA		Mouse	PMID:10849425
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rnf4	IDA		Rat	PMID:9710597\|RGD:69969
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF4	IMP		Human	PMID:18408734
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF4	IMP		Human	PMID:20212317
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF4	IMP		Human	PMID:20943951
Biological Process	GO:0051865	protein autoubiquitination	Rnf4	IMP		Rat	PMID:14987998\|RGD:8554770
Biological Process	GO:0051865	protein autoubiquitination	Rnf4	IDA		Rat	PMID:21857666\|RGD:9831417
Biological Process	GO:0070979	protein K11-linked ubiquitination	Rnf4	IDA		Rat	PMID:18408734\|RGD:8553731
Biological Process	GO:0070936	protein K48-linked ubiquitination	Rnf4	IDA		Rat	PMID:18408734\|RGD:8553731
Biological Process	GO:0085020	protein K6-linked ubiquitination	Rnf4	IDA		Rat	PMID:18408734\|RGD:8553731
Biological Process	GO:0070534	protein K63-linked ubiquitination	Rnf4	IDA		Rat	PMID:18408734\|RGD:8553731
Biological Process	GO:0016567	protein ubiquitination	Rnf4	IMP		Rat	PMID:14987998\|RGD:8554770
Biological Process	GO:0090234	regulation of kinetochore assembly	RNF4	IMP		Human	PMID:20212317
Biological Process	GO:0090169	regulation of spindle assembly	RNF4	IMP		Human	PMID:20212317
Biological Process	GO:0046685	response to arsenic-containing substance	RNF4	IDA		Human	PMID:20943951
Biological Process	GO:0046685	response to arsenic-containing substance	Rnf4	IDA		Rat	PMID:20943951\|RGD:8553289
Biological Process	GO:0032355	response to estradiol	Rnf4	IEP		Rat	PMID:14749358\|RGD:9831414
Biological Process	GO:0044752	response to human chorionic gonadotropin	Rnf4	IEP		Rat	PMID:14749358\|RGD:9831414
Biological Process	GO:0007283	spermatogenesis	Rnf4	IEP		Rat	PMID:12351196\|RGD:9831411

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.