Rnf4 MGI Mouse Gene Detail - MGI:1201691

Symbol

Rnf4
Name

ring finger protein 4
Synonyms

Gtrgeo8

Feature Type

protein coding gene
IDs

MGI:1201691
NCBI Gene: 19822
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:34493594-34510789 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.87 cM
Mapping Data

2 experiments

SNPs within 2kb

393 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201691	protein coding gene	Chr5:34493594-34512973 (+)
129S1/SvImJ	ENSMUSG00200011686	protein coding gene	Chr5:29962690-29979841 (+)
A/J	ENSMUSG00195048982	protein coding gene	Chr5:29434322-29451476 (+)
AKR/J	ENSMUSG00220007409	protein coding gene	Chr5:29454713-29471867 (+)
BALB/cJ	ENSMUSG00180035173	protein coding gene	Chr5:29237228-29254382 (+)
C3H/HeJ	ENSMUSG00175019333	protein coding gene	Chr5:31216817-31233972 (+)
C57BL/6NJ	ENSMUSG00215040524	protein coding gene	Chr5:29959908-29977059 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027131	protein coding gene	Chr5:29265480-29286734 (+)
CAST/EiJ	ENSTCUG00005023251	protein coding gene	Chr5:29427008-29443939 (+)
CBA/J	ENSMUSG00210003758	protein coding gene	Chr5:30184516-30201669 (+)
DBA/2J	ENSMUSG00185016386	protein coding gene	Chr5:32054625-32071776 (+)
FVB/NJ	ENSMUSG00205024181	protein coding gene	Chr5:28933991-28951118 (+)
JF1/MsJ	ENSUMUG00000022051	protein coding gene	Chr5:36651487-36668837 (+)
LP/J	ENSMUSG00230042767	protein coding gene	Chr5:36666365-36683515 (+)
NOD/ShiLtJ	ENSMUSG00190014407	protein coding gene	Chr5:29216096-29233223 (+)
NZO/HlLtJ	ENSMUSG00225015400	protein coding gene	Chr5:41872607-41889758 (+)
PWK/PhJ	ENSLUMG00010042829	protein coding gene	Chr5:29345621-29362978 (+)
SPRET/EiJ	ENSMSPG00010034674	protein coding gene	Chr5:30534251-30556089 (+)
WSB/EiJ	ENSIUOG00005018192	protein coding gene	Chr5:32142578-32159703 (+)

Human Ortholog

RNF4, ring finger protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF4, ring finger protein 4
Synonyms

RES4-26, SLX5, SNURF
Links

HGNC:10067

NCBI Gene ID: 6047

UniProt: P78317
Chr Location

4p16.3; chr4:2462220-2515859 (+) GRCh38

MGI Vertebrate Homology

Rnf4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF4
Gene Tree

Rnf4

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

59
Radiation induced

5
Spontaneous

1
Genomic Mutations

9 involving Rnf4
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display lethality throughout fetal growth and development with ventricular septal defects and cardiac insufficiency. MEFs from homozygous mice display global DNA hypermethylation.

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All GO Annotations

93
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

95
cDNA Data

28
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf4

ZFIN rnf4

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All Sequences

87
RefSeq

6
UniProt

4
CCDS

CCDS57336.1

Ensembl

ENSMUSG00000029110 (Evidence)
NCBI Gene

19822

			Length	Strain/Species	Flank
genomic	19822	NCBI Gene Model \| MGI Sequence Detail	17196	C57BL/6J	± kb
transcript	NM_011278	RefSeq \| MGI Sequence Detail	3091	C57BL/6
polypeptide	Q9QZS2	UniProt \| EBI \| MGI Sequence Detail	194	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014134 E3 ubiquitin-protein ligase RNF4

(term hierarchy)
PDB

2MP2
EC

2.3.2.27
InterPro Domains

IPR047134 E3 ubiquitin-protein ligase RNF4

IPR043295 RNF4, RING finger, HC subclass

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 31

cDNA 29

Primer pair 1

Other 1

Microarray probesets 4

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MGI:2141039, MGI:894658

Summaries

All 88

Developmental Gene Expression 9

Diseases 1

Gene Ontology 13

Phenotypes 34
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:348296 Her J, et al., RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication. J Clin Invest. 2024 Mar 26;134(10)

TSS for Rnf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45866	Chr5:34493728-34493739 (+)	140 bp
Tssr45867	Chr5:34493745-34493803 (+)	180 bp
Tssr45868	Chr5:34494272-34494281 (+)	683 bp
Tssr45869	Chr5:34494296-34494303 (+)	706 bp
Tssr45870	Chr5:34494308-34494360 (+)	740 bp
Tssr45871	Chr5:34509427-34509456 (+)	15,848 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24