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Rnf4
Gene Detail
 Symbol
Name
ID
Rnf4
ring finger protein 4
MGI:1201691
Synonyms Gtrgeo8
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:34336289-34355629 bp, + strand
From VEGA annotation of GRCm38

  19341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rnf4

Human
homologs
Human Homolog RNF4, ring finger protein 4
NCBI Gene ID 6047
neXtProt AC  NX_P78317
Human Synonyms  SLX5, SNURF
Human Chr (Location)  4p16.3; chr4:2469068-2515859 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Chemically induced (ENU)(1) Gene trapped(61) Radiation induced(5)
Genomic Mutations involving Rnf4 (6)
 
Mice homozygous for a null mutation display lethality throughout fetal growth and development with ventricular septal defects and cardiac insufficiency. MEFs from homozygous mice display global DNA hypermethylation.
 
Alleles Annotated to Human Diseases(4)   
Interactions
Rnf4 interacts with 273 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process cellular response to gamma radiation, cellular response to hydroxyurea, ...
Component cytoplasm, nucleoplasm, ...
Function androgen receptor binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (56)    Tissues (56)    Images (5)
Theiler Stages: 10, 17, 18, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 44
Northern blot 12
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000043581 (Evidence)
Ensembl Gene ModelENSMUSG00000029110 (Evidence)
Entrez Gene19822 (Evidence)
DFCITC1573842, TC1623725
DoTSDT.101144927, DT.101237946, DT.101405027, DT.110699012, DT.94245498, DT.94245500, DT.97371817, DT.99866209
EC6.3.2.-
Consensus CDS ProjectCCDS57336.1
International Mouse Knockout Project StatusRnf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043581 VEGA Gene Model | MGI Sequence Detail 19341 C57BL/6J ±  kb
transcript OTTMUST00000114418 VEGA | MGI Sequence Detail 3043 Not Applicable 
polypeptide OTTMUSP00000063857 VEGA | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000014134 E3 ubiquitin-protein ligase RNF4
References (Earliest) J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
(Latest) J:202921 Ragland RL, et al., RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes Dev. 2013 Oct 15;27(20):2259-73
All references(47)
Other
accession IDs
MGI:2141039, MGI:894658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory