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Rnf4 Gene Detail
Summary
  • Symbol
    Rnf4
  • Name
    ring finger protein 4
  • Synonyms
    Gtrgeo8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201691
    NCBI Gene: 19822
  • Gene Overview
    MyGene.info: RNF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:34336289-34355629 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19341 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.87 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF4, ring finger protein 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF4, ring finger protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RES4-26, SLX5, SNURF
  • Links
    NCBI Gene ID: 6047
    neXtProt AC: NX_P78317
    UniProt: P78317

  • Chr Location
    4p16.3; chr4:2469068-2515859 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display lethality throughout fetal growth and development with ventricular septal defects and cardiac insufficiency. MEFs from homozygous mice display global DNA hypermethylation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000043581 VEGA Gene Model | MGI Sequence Detail 19341 C57BL/6J ±  kb
    transcript OTTMUST00000114417 VEGA | MGI Sequence Detail 2895 Not Applicable  
    polypeptide OTTMUSP00000063856 VEGA | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      80 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141039, MGI:894658
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:224272 Sun H, et al., Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control. Mol Cell Biol. 2014 Aug;34(16):2981-95

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory