About   Help   FAQ
Rnf4
Gene Detail
Symbol

Name
ID
Rnf4
ring finger protein 4
MGI:1201691
Synonyms
Gtrgeo8
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:34336289-34355629 bp, + strand
From VEGA annotation of GRCm38

  19341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RNF4
Gene Tree: Rnf4

Human
homologs
RNF4, ring finger protein 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6047
neXtProt AC: NX_P78317

Human Synonyms: RES4-26, SLX5, SNURF

Human Chr (Location): 4p16.3; chr4:2469068-2515859 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(68) : Chemically induced (ENU)(1) Gene trapped(61) Radiation induced(6)
Genomic Mutations involving Rnf4 (7)
 
Mice homozygous for a null mutation display lethality throughout fetal growth and development with ventricular septal defects and cardiac insufficiency. MEFs from homozygous mice display global DNA hypermethylation.
 
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Rnf4 interacts with 273 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process cellular response to gamma radiation, cellular response to hydroxyurea, ...
Component cytoplasm, cytosol, ...
Function androgen receptor binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (56)    Tissues (56)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
Northern blot 12
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnf4    NEW 
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000043581 (Evidence)
Ensembl Gene Model ENSMUSG00000029110 (Evidence)
Entrez Gene 19822 (Evidence)
DFCI TC1676924, TC1623725, TC1573842
DoTS DT.101405027, DT.101237946, DT.101144927, DT.110699188, DT.110699012, DT.97371817, DT.99866209, DT.94245500, DT.94245498
EC 6.3.2.-
PDB 2MP2
Consensus CDS Project CCDS57336.1
International Mouse Phenotyping Consortium Status Rnf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043581 VEGA Gene Model | MGI Sequence Detail 19341 C57BL/6J ±  kb
transcript OTTMUST00000114418 VEGA | MGI Sequence Detail 3043 Not Applicable 
polypeptide OTTMUSP00000063857 VEGA | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000014134 E3 ubiquitin-protein ligase RNF4
References
(Earliest) J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
(Latest) J:215335 Guo L, et al., A cellular system that degrades misfolded proteins and protects against neurodegeneration. Mol Cell. 2014 Jul 3;55(1):15-30
All references(46)
Other
accession IDs
MGI:2141039, MGI:894658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory