Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFX2
  • Mouse genes Rfx2
  • Rat genes Rfx2
  • Zfish genes rfx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rfx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Rfx2	IMP		Mouse	MGI:MGI:5825433|PMID:14743396
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rfx2	IMP		Mouse	MGI:MGI:5708804|PMID:26162102
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rfx2	IMP		Mouse	MGI:MGI:5763317|PMID:26853561
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rfx2	IDA		Rat	PMID:18247329|RGD:11041070
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q8HWS3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q92949	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q92949	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:O00167-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:O75928-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q8HWS3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q8NI38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q92949	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX2	IPI	UniProtKB:Q96NZ1	Human	PMID:32296183
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Rfx2	IMP		Mouse	MGI:MGI:5708804|PMID:26162102
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Rfx2	IMP		Mouse	MGI:MGI:5763317|PMID:26853561
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Rfx2	IDA		Rat	PMID:16676351|RGD:11041022
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Rfx2	IDA		Rat	PMID:18247329|RGD:11041070
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Rfx2	IMP		Mouse	MGI:MGI:79955|PMID:8289803
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	RFX2	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Rfx2	IDA		Rat	PMID:16676351|RGD:11041022
Cellular Component	GO:0005634	nucleus	Rfx2	IDA		Rat	PMID:16676351|RGD:11041022
Biological Process	GO:0001675	acrosome assembly	Rfx2	IMP		Mouse	MGI:MGI:5708804|PMID:26162102
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Rfx2	IEP		Mouse	PMID:20439489
Biological Process	GO:0060271	cilium assembly	Rfx2	IMP		Mouse	MGI:MGI:5708804|PMID:26162102
Biological Process	GO:0060271	cilium assembly	Rfx2	IMP		Mouse	MGI:MGI:5763317|PMID:26853561
Biological Process	GO:0007368	determination of left/right symmetry	rfx2	IMP	ZFIN:ZDB-MRPHLNO-120326-1	Zfish	PMID:22233545
Biological Process	GO:0070121	Kupffer's vesicle development	rfx2	IMP	ZFIN:ZDB-MRPHLNO-120326-1	Zfish	PMID:22233545
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rfx2	IMP		Mouse	MGI:MGI:5825433|PMID:14743396
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rfx2	IMP		Mouse	MGI:MGI:5763317|PMID:26853561
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rfx2	IMP		Mouse	MGI:MGI:5708804|PMID:26162102
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rfx2	IDA		Rat	PMID:18247329|RGD:11041070
Biological Process	GO:0007286	spermatid development	Rfx2	IMP		Mouse	MGI:MGI:5699785|PMID:26248850
Biological Process	GO:0007286	spermatid development	Rfx2	IMP		Mouse	MGI:MGI:5763317|PMID:26853561
Biological Process	GO:0007286	spermatid development	Rfx2	IMP		Mouse	MGI:MGI:5708804|PMID:26162102

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern