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Rfx2 Gene Detail
Summary
  • Symbol
    Rfx2
  • Name
    regulatory factor X, 2 (influences HLA class II expression)
  • Synonyms
    5430432H19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106583
    NCBI Gene: 19725
  • Gene Overview
    MyGene.info: RFX2
Location & Maps
more
  • Sequence Map
    Chr17:56775897-56831008 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55112 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RFX2, regulatory factor X2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RFX2, regulatory factor X2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 5990
    neXtProt AC: NX_P48378

  • Chr Location
    19p13.3; chr19:5993164-6110653 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are viable and lack an obvious embryonic phenotype but exhibit male infertility associated with a defect in spermatid maturation at or before the round and elongating spermatid stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024206 Ensembl Gene Model | MGI Sequence Detail 55112 C57BL/6J ±  kb
transcript ENSMUST00000002444 Ensembl | MGI Sequence Detail 3353 Not Applicable  
polypeptide ENSMUSP00000002444 Ensembl | MGI Sequence Detail 717 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    135 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013924 DNA-binding protein RFX2
  • InterPro Domains
    IPR003150 DNA-binding RFX-type winged-helix domain
    IPR007668 RFX1 transcription activation region
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 32
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35039, MGI:1918654
References
more
  • Summaries
    All 44
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:32459 Reith W, et al., RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol. 1994 Feb;14(2):1230-44
  • Latest
    J:228765 Kistler WS, et al., RFX2 Is a Major Transcriptional Regulator of Spermiogenesis. PLoS Genet. 2015 Jul;11(7):e1005368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory