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Rfx2
Gene Detail
Symbol

Name
ID
Rfx2
regulatory factor X, 2 (influences HLA class II expression)
MGI:106583
Synonyms
5430432H19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.50 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:56775897-56831008 bp, - strand
From Ensembl annotation of GRCm38

  55112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30980  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RFX2
Protein SuperFamily: DNA binding protein RFX2
Gene Tree: Rfx2

Human
homologs
RFX2, regulatory factor X, 2 (influences HLA class II expression)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5990
neXtProt AC: NX_P48378

Human Chr (Location): 19p13.3; chr19:5993164-6110653 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(96) : Gene trapped(94) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Rfx2 interacts with 167 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (227)    Tissues (159)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 219
RT-PCR 8
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RFX2 ; Xenbase rfx2 ; ZFIN rfx2    NEW 
Molecular
reagents
All nucleic(35) cDNA(32) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024206 (Evidence)
Entrez Gene 19725 (Evidence)
UniGene 102
DFCI TC1615597, TC1595123, TC1580838
DoTS DT.489713, DT.91577205, DT.94182586
NIA Mouse Gene Index U037958
Consensus CDS Project CCDS28915.1, CCDS50156.1
International Mouse Phenotyping Consortium Status Rfx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024206 Ensembl Gene Model | MGI Sequence Detail 55112 C57BL/6J ±  kb
transcript ENSMUST00000002444 Ensembl | MGI Sequence Detail 3353 Not Applicable 
polypeptide ENSMUSP00000002444 Ensembl | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003150 DNA-binding RFX-type winged-helix domain
InterPro IPR007668 RFX1 transcription activation region
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013924 DNA-binding protein RFX2
References
(Earliest) J:32459 Reith W, et al., RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol. 1994 Feb;14(2):1230-44
(Latest) J:182770 Bisgrove BW, et al., RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Dev Biol. 2012 Mar 1;363(1):166-78
All references(44)
Other
accession IDs
MGD-MRK-35039, MGI:1918654

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory