Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ret

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RET
- Mouse genes Ret
- Rat genes Ret
- Zfish genes ret
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ret

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	RET	IDA		Human	PMID:11445581
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q07731	Human	PMID:10545102
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:P40763	Human	PMID:11536047
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q62985	Human	PMID:16569669
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q62985	Human	PMID:17471236
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:P47736	Human	PMID:20877310
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:P39905	Human	PMID:21994944
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:P40763	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q6UXV0	Human	PMID:28846097
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q6UXV0	Human	PMID:28846099
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q6UXV0	Human	PMID:28953886
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:P22455	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	RET	IPI	UniProtKB:Q9UM73	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Ret	IPI	UniProtKB:Q60629	Mouse	MGI:MGI:5307244\|PMID:22304922
Molecular Function	GO:0005515	protein binding	Ret	IPI	UniProtKB:Q6SJE0	Mouse	MGI:MGI:6103585\|PMID:28846099
Molecular Function	GO:0005515	protein binding	Ret	IPI	PR:O35118	Mouse	PMID:9452475
Molecular Function	GO:0005515	protein binding	Ret	IPI	PR:O35118	Mouse	PMID:15204970
Molecular Function	GO:0005515	protein binding	Ret	IPI	PR:Q4ACU6	Mouse	PMID:15569713
Molecular Function	GO:0005515	protein binding	Ret	IPI	RGD:1309908	Rat	PMID:20877310\|RGD:9835042
Molecular Function	GO:0005515	protein binding	ret	IPI	ZFIN:ZDB-GENE-010226-1,ZFIN:ZDB-GENE-010226-2	Zfish	PMID:28467503
Molecular Function	GO:0042803	protein homodimerization activity	ret	IPI	ZFIN:ZDB-GENE-980526-307	Zfish	PMID:29889908
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	RET	IDA		Human	PMID:28846099
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Ret	IDA		Mouse	MGI:MGI:6103585\|PMID:28846099
Cellular Component	GO:0030424	axon	Ret	IDA		Rat	PMID:20877310\|RGD:9835042
Cellular Component	GO:0030425	dendrite	Ret	IDA		Rat	PMID:20877310\|RGD:9835042
Cellular Component	GO:0005769	early endosome	Ret	IDA		Rat	PMID:20877310\|RGD:9835042
Cellular Component	GO:0010008	endosome membrane	RET	IDA		Human	PMID:19823924
Cellular Component	GO:0045121	membrane raft	Ret	IDA		Rat	PMID:16525057\|RGD:2324947
Cellular Component	GO:0043025	neuronal cell body	Ret	IDA		Rat	PMID:20877310\|RGD:9835042
Cellular Component	GO:0005886	plasma membrane	RET	IDA		Human	PMID:19823924
Cellular Component	GO:0005886	plasma membrane	RET	IDA		Human	PMID:28953886
Cellular Component	GO:0098797	plasma membrane protein complex	RET	IDA		Human	PMID:10545102
Cellular Component	GO:0043235	receptor complex	RET	IDA		Human	PMID:23382219
Biological Process	GO:0048675	axon extension	ret	IMP	ZFIN:ZDB-GENO-200827-1	Zfish	PMID:31476133
Biological Process	GO:0048675	axon extension	ret	IMP	ZFIN:ZDB-CRISPR-200312-1,ZFIN:ZDB-CRISPR-200312-2,ZFIN:ZDB-CRISPR-200312-3	Zfish	PMID:31476133
Biological Process	GO:0014707	branchiomeric skeletal muscle development	ret	IMP	ZFIN:ZDB-GENO-100507-13	Zfish	PMID:21490065
Biological Process	GO:0071300	cellular response to retinoic acid	RET	IMP		Human	PMID:17910947
Biological Process	GO:0001838	embryonic epithelial tube formation	Ret	IGI	MGI:MGI:1930016	Mouse	PMID:15569713
Biological Process	GO:0048484	enteric nervous system development	Ret	IMP	MGI:MGI:2136894	Mouse	PMID:9834195
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-CRISPR-230208-6,ZFIN:ZDB-MRPHLNO-081020-2	Zfish	PMID:34358225
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-CRISPR-230208-7,ZFIN:ZDB-MRPHLNO-081020-2	Zfish	PMID:34358225
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-MRPHLNO-081020-2,ZFIN:ZDB-MRPHLNO-150506-2	Zfish	PMID:25575569
Biological Process	GO:0048484	enteric nervous system development	ret	IMP	ZFIN:ZDB-MRPHLNO-061204-2	Zfish	PMID:14660438
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-GENO-170323-3,ZFIN:ZDB-MRPHLNO-170310-1	Zfish	PMID:27902697
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-MRPHLNO-051128-4,ZFIN:ZDB-MRPHLNO-081020-2	Zfish	PMID:25839327
Biological Process	GO:0048484	enteric nervous system development	ret	IMP	ZFIN:ZDB-MRPHLNO-081020-3	Zfish	PMID:18565740
Biological Process	GO:0048484	enteric nervous system development	ret	IMP	ZFIN:ZDB-MRPHLNO-081020-2	Zfish	PMID:18565740
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-GENO-170327-3	Zfish	PMID:27902697
Biological Process	GO:0048484	enteric nervous system development	ret	IMP	ZFIN:ZDB-GENO-100507-13	Zfish	PMID:27902697
Biological Process	GO:0048484	enteric nervous system development	ret	IMP	ZFIN:ZDB-GENO-170323-3	Zfish	PMID:27902697
Biological Process	GO:0048484	enteric nervous system development	ret	IGI	ZFIN:ZDB-MRPHLNO-081020-2	Zfish	PMID:25839327
Biological Process	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	RET	IDA		Human	PMID:28953886
Biological Process	GO:0060384	innervation	Ret	IMP		Rat	PMID:18501516\|RGD:2324932
Biological Process	GO:0000165	MAPK cascade	Ret	IGI	MGI:MGI:1930016	Mouse	PMID:15569713
Biological Process	GO:0033619	membrane protein proteolysis	RET	IDA		Human	PMID:21357690
Biological Process	GO:0007399	nervous system development	Ret	IMP	MGI:MGI:2136894	Mouse	PMID:11069590
Biological Process	GO:0001755	neural crest cell migration	Ret	IMP	MGI:MGI:2449909	Mouse	PMID:15242795
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	ret	IMP	ZFIN:ZDB-GENO-170323-3	Zfish	PMID:27902697
Biological Process	GO:0007158	neuron cell-cell adhesion	RET	IMP		Human	PMID:21357690
Biological Process	GO:0007158	neuron cell-cell adhesion	Ret	IDA		Mouse	MGI:MGI:5306544\|PMID:21357690
Biological Process	GO:0030182	neuron differentiation	Ret	IMP	MGI:MGI:2386570,MGI:MGI:4413350	Mouse	PMID:17553423
Biological Process	GO:0042551	neuron maturation	Ret	IMP	MGI:MGI:2136894	Mouse	PMID:15233745
Biological Process	GO:0061146	Peyer's patch morphogenesis	Ret	IMP		Mouse	MGI:MGI:3708043\|PMID:17322904
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	RET	IDA		Human	PMID:20702524
Biological Process	GO:0030335	positive regulation of cell migration	RET	IDA		Human	PMID:20702524
Biological Process	GO:0045793	positive regulation of cell size	Ret	IMP	MGI:MGI:2386570,MGI:MGI:4413350	Mouse	PMID:17553423
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ret	IMP		Mouse	MGI:MGI:3697544\|PMID:17047028
Biological Process	GO:0010628	positive regulation of gene expression	Ret	IMP	MGI:MGI:3819163	Mouse	PMID:22897442
Biological Process	GO:0010628	positive regulation of gene expression	Ret	IMP		Mouse	PMID:22897442
Biological Process	GO:0043410	positive regulation of MAPK cascade	RET	IDA		Human	PMID:28846099
Biological Process	GO:0043410	positive regulation of MAPK cascade	RET	IMP		Human	PMID:28953886
Biological Process	GO:0072300	positive regulation of metanephric glomerulus development	Ret	IMP		Mouse	MGI:MGI:3697544\|PMID:17047028
Biological Process	GO:0014042	positive regulation of neuron maturation	Ret	IMP		Rat	PMID:18501516\|RGD:2324932
Biological Process	GO:0010976	positive regulation of neuron projection development	RET	IMP		Human	PMID:17910947
Biological Process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	Ret	IMP		Mouse	PMID:23872421
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	RET	IMP		Human	PMID:28846097
Biological Process	GO:0072114	pronephros morphogenesis	ret	IMP	ZFIN:ZDB-CRISPR-170607-1	Zfish	PMID:28121514
Biological Process	GO:0072114	pronephros morphogenesis	ret	IMP	ZFIN:ZDB-MRPHLNO-081020-3	Zfish	PMID:28121514
Biological Process	GO:0065003	protein-containing complex assembly	ret	IPI	ZFIN:ZDB-GENE-010226-1,ZFIN:ZDB-GENE-010226-2,ZFIN:ZDB-GENE-980526-307	Zfish	PMID:29889908
Biological Process	GO:0050770	regulation of axonogenesis	Ret	IMP	MGI:MGI:2386570,MGI:MGI:4413350	Mouse	PMID:17553423
Biological Process	GO:0030155	regulation of cell adhesion	RET	IDA		Human	PMID:21357690
Biological Process	GO:0048265	response to pain	Ret	IMP		Mouse	MGI:MGI:4441221\|PMID:20237269
Biological Process	GO:0009410	response to xenobiotic stimulus	Ret	IEP		Rat	PMID:15837122\|RGD:2324949
Biological Process	GO:0060041	retina development in camera-type eye	Ret	IEP		Rat	PMID:16650834\|RGD:2324945
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Ret	IGI	MGI:MGI:108417	Mouse	PMID:9576965
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Ret	IGI	MGI:MGI:1195462	Mouse	PMID:9576965
Biological Process	GO:0035799	ureter maturation	Ret	IMP	MGI:MGI:2136894	Mouse	PMID:21521737
Biological Process	GO:0001657	ureteric bud development	Ret	IMP	MGI:MGI:2136894	Mouse	PMID:12195422

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.