Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes REN
  • Mouse genes Ren1
  • Rat genes Ren
  • Zfish genes ren
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ren1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	EXP		Human	PMID:12045255
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	IDA		Human	PMID:12045255
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	IDA		Human	PMID:20927107
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	EXP		Human	PMID:4289389
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	EXP		Human	PMID:4322712
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	EXP		Human	PMID:4330891
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	REN	EXP		Human	PMID:4360430
Molecular Function	GO:0004175	endopeptidase activity	Ren1	IDA		Mouse	PMID:19293336
Molecular Function	GO:0004175	endopeptidase activity	Ren	IDA		Rat	PMID:7060565|RGD:2311700
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	Ren	IDA		Rat	PMID:11247783|RGD:1581738
Molecular Function	GO:0008233	peptidase activity	REN	IDA		Human	PMID:12045255
Molecular Function	GO:0005515	protein binding	REN	IPI	UniProtKB:P01019	Human	PMID:20927107
Molecular Function	GO:0005102	signaling receptor binding	REN	IPI	UniProtKB:O75787	Human	PMID:12045255
Molecular Function	GO:0005102	signaling receptor binding	Ren	IPI	RGD:1561269	Rat	PMID:21321306|RGD:5132599
Cellular Component	GO:0045177	apical part of cell	REN	IDA		Human	PMID:26322847
Cellular Component	GO:0005737	cytoplasm	Ren	IDA		Rat	PMID:12242043|RGD:1581651
Cellular Component	GO:0005615	extracellular space	REN	IDA		Human	PMID:12045255
Cellular Component	GO:0005615	extracellular space	REN	IDA		Human	PMID:26322847
Cellular Component	GO:0005615	extracellular space	Ren1	IDA		Mouse	PMID:19293336
Cellular Component	GO:0005615	extracellular space	Ren1	IDA		Mouse	PMID:10318840
Cellular Component	GO:0005615	extracellular space	Ren	IDA		Rat	PMID:1278112|RGD:2311698
Cellular Component	GO:0005622	intracellular anatomical structure	Ren1	IDA		Mouse	PMID:19293336
Biological Process	GO:0050435	amyloid-beta metabolic process	Ren	IEP		Rat	PMID:22609375|RGD:6892653
Biological Process	GO:0002003	angiotensin maturation	REN	IDA		Human	PMID:12045255
Biological Process	GO:0002003	angiotensin maturation	Ren1	IMP	MGI:MGI:2136642	Mouse	PMID:10617578
Biological Process	GO:0002003	angiotensin maturation	Ren	IDA		Rat	PMID:21321306|RGD:5132599
Biological Process	GO:0048469	cell maturation	Ren1	IMP	MGI:MGI:2136642	Mouse	PMID:10617578
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Ren	IEP		Rat	PMID:21963836|RGD:6892652
Biological Process	GO:0042756	drinking behavior	Ren1	IMP	MGI:MGI:2136642	Mouse	PMID:10617578
Biological Process	GO:0009755	hormone-mediated signaling pathway	Ren1	IDA		Mouse	PMID:14583438
Biological Process	GO:0072051	juxtaglomerular apparatus development	Ren	IEP		Rat	PMID:30645697|RGD:155631307
Biological Process	GO:0001822	kidney development	REN	IMP		Human	PMID:16116425
Biological Process	GO:0008584	male gonad development	Ren1	IEP		Mouse	MGI:MGI:1930324|PMID:11145610
Biological Process	GO:0001823	mesonephros development	Ren1	IEP		Mouse	MGI:MGI:1930324|PMID:11145610
Biological Process	GO:0006508	proteolysis	REN	IDA		Human	PMID:12045255
Biological Process	GO:0008217	regulation of blood pressure	Ren1	IDA		Mouse	PMID:27754863
Biological Process	GO:0008217	regulation of blood pressure	Ren	IMP		Rat	PMID:8567976|RGD:61046
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	Ren1	IMP	MGI:MGI:2136642	Mouse	PMID:10617578
Biological Process	GO:0043408	regulation of MAPK cascade	REN	IDA		Human	PMID:12045255
Biological Process	GO:0002018	renin-angiotensin regulation of aldosterone production	Ren1	IDA		Mouse	PMID:19293336
Biological Process	GO:0051591	response to cAMP	Ren	IDA		Rat	PMID:9671794|RGD:2311696
Biological Process	GO:0070305	response to cGMP	Ren	IDA		Rat	PMID:9671794|RGD:2311696
Biological Process	GO:0035902	response to immobilization stress	Ren	IEP		Rat	PMID:7042704|RGD:2311699
Biological Process	GO:0032496	response to lipopolysaccharide	Ren	IEP		Rat	PMID:22342485|RGD:6892689
Biological Process	GO:0010033	response to organic substance	Ren1	IDA		Mouse	PMID:19293336
Biological Process	GO:0009410	response to xenobiotic stimulus	Ren	IDA		Rat	PMID:9671794|RGD:2311696

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern