Ren1
Gene Detail

Symbol Name ID

Ren1 renin 1 structural MGI:97898

STS

D1Mit31

Synonyms

Ren, Ren-1, Ren1c, Ren1d, Ren-A, Rn-1, Rnr

Feature Type

protein coding gene

Genetic Map

Chromosome 1

57.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)

Sequence Map

Chr1:133350510-133360325 bp, + strand From VEGA annotation of GRCm38   9816 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Pepsin
Gene Tree: Ren1

Human homologs

Human Homolog		REN, renin
NCBI Gene ID		5972
neXtProt AC		NX_P00797
Human Synonyms		HNFJ2
Human Chr (Location)		1q32; chr1:204123944-204135465 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human REN

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Homozygous inactivation of this gene leads to postnatal lethality, reduced plasma renin level, decreased mean arterial pressure, and kidney defects such as atrophy, altered juxtaglomerular cell and macula densa morphology, polyuria, decreased urine osmolality, and reduced glomerular filtration rate.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	angiotensin maturation, cell maturation, ...
Component	cytoplasmic part, extracellular region, ...
Function	aspartic-type endopeptidase activity, endopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (148)    Tissues (44)    Images (37)
Theiler Stages: 18, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	77
Northern blot	22
RT-PCR	44

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(16) cDNA(18) Primer pair(4) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000021617 (Evidence)
Ensembl Gene Model	ENSMUSG00000070645 (Evidence)
Entrez Gene	19701 (Evidence)
DoTS	DT.91403692, DT.110906117
EC	3.4.23.15
Consensus CDS Project	CCDS15295.1
International Mouse Knockout Project Status	Ren1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021617	VEGA Gene Model | MGI Sequence Detail	9816	C57BL/6J
transcript	OTTMUST00000051330	VEGA | MGI Sequence Detail	1592	Not Applicable
polypeptide	OTTMUSP00000024128	VEGA | MGI Sequence Detail	402	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(11) : PCR(2) RFLP(9) SNPs(219 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021109	Aspartic peptidase
InterPro	IPR001461	Peptidase A1
InterPro	IPR001969	Peptidase aspartic, active site
InterPro	IPR012848	Propeptide, peptidase A1
Protein Ontology	PR:000014394	renin-1

References

(Earliest) J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
(Latest) J:188656 Pentz ES, et al., Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype. Am J Physiol Heart Circ Physiol. 2012 Jun 15;302(12):H2545-52
All references(158)

Other accession IDs

MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13836, MGD-MRK-13838, MGD-MRK-13917, MGD-MRK-13951, MGI:2138723