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Ren1
Gene Detail
Symbol

Name
ID
Ren1
renin 1 structural
MGI:97898
STS
Synonyms
Ren, Ren-1, Ren1c, Ren1d, Ren-A, Rn-1, Rnr
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr1:133350510-133360325 bp, + strand
From VEGA annotation of GRCm38

  9816 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Pepsin
Gene Tree: Ren1

Human
homologs
Human Homolog REN, renin
NCBI Gene ID 5972
neXtProt AC  NX_P00797
Human Synonyms  HNFJ2
Human Chr (Location)  1q32; chr1:204154816-204166337 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human REN
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to postnatal lethality, reduced plasma renin level, decreased mean arterial pressure, and kidney defects such as atrophy, altered juxtaglomerular cell and macula densa morphology, polyuria, decreased urine osmolality, and reduced glomerular filtration rate.
 
Phenotype Images(2)
Interactions
Ren1 interacts with 27 markers (Mir185, Mir196a-1, Mir196a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process angiotensin maturation, cell maturation, ...
Component cytoplasm, extracellular region, ...
Function aspartic-type endopeptidase activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (186)    Tissues (78)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 115
Northern blot 22
RT-PCR 44
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(16) cDNA(18) Primer pair(4) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000021617 (Evidence)
Ensembl Gene ModelENSMUSG00000070645 (Evidence)
Entrez Gene19701 (Evidence)
DoTSDT.91403692, DT.110906117
EC3.4.23.15
Consensus CDS ProjectCCDS15295.1
International Mouse Knockout Project StatusRen1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021617 VEGA Gene Model | MGI Sequence Detail 9816 C57BL/6J ±  kb
transcript OTTMUST00000051330 VEGA | MGI Sequence Detail 1592 Not Applicable 
polypeptide OTTMUSP00000024128 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(11) : PCR(2) RFLP(9) SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
InterPro IPR012848 Propeptide, peptidase A1
Protein Ontology PR:000014394 renin-1
References
(Earliest) J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
(Latest) J:211090 Lakhe-Reddy S, et al., Mesangial cell alphavbeta8-integrin regulates glomerular capillary integrity and repair. Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1400-9
All references(160)
Other
accession IDs
MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13836, MGD-MRK-13838, MGD-MRK-13917, MGD-MRK-13951, MGI:2138723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory