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Ren1
Gene Detail
Symbol

Name
ID
Ren1
renin 1 structural
MGI:97898
STS
Synonyms
Ren, Ren-1, Ren1c, Ren1d, Ren-A, Rn-1, Rnr
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr1:133350510-133360325 bp, + strand
From VEGA annotation of GRCm38

  9816 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: REN
Protein SuperFamily: Pepsin
Gene Tree: Ren1

Human
homologs
REN, renin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5972
neXtProt AC: NX_P00797

Human Synonyms: HNFJ2

Human Chr (Location): 1q32; chr1:204154816-204166337 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human REN

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(11) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to postnatal lethality, reduced plasma renin level, decreased mean arterial pressure, and kidney defects such as atrophy, altered juxtaglomerular cell and macula densa morphology, polyuria, decreased urine osmolality, and reduced glomerular filtration rate.
 
Phenotype Images(2)
Interactions
Ren1 interacts with 27 markers (Mir185, Mir196a-1, Mir196a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process angiotensin maturation, cell maturation, ...
Component cytoplasm, extracellular region, ...
Function aspartic-type endopeptidase activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (186)    Tissues (84)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 115
Northern blot 22
RT-PCR 44
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ren    NEW 
Molecular
reagents
All nucleic(40) Genomic(16) cDNA(18) Primer pair(4) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000021617 (Evidence)
Ensembl Gene Model ENSMUSG00000070645 (Evidence)
Entrez Gene 19701 (Evidence)
DoTS DT.110906117, DT.91403692
EC 3.4.23.15
Consensus CDS Project CCDS15295.1
International Mouse Phenotyping Consortium Status Ren1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021617 VEGA Gene Model | MGI Sequence Detail 9816 C57BL/6J ±  kb
transcript OTTMUST00000051330 VEGA | MGI Sequence Detail 1592 Not Applicable 
polypeptide OTTMUSP00000024128 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(11) : PCR(2) RFLP(9) SNPs within 2kb(393 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001461 Aspartic peptidase
InterPro IPR001969 Aspartic peptidase, active site
InterPro IPR021109 Aspartic peptidase domain
InterPro IPR012848 Aspartic peptidase, N-terminal
Protein Ontology PR:000014394 renin-1
References
(Earliest) J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
(Latest) J:218046 Cuffe JS, et al., The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61
All references(158)
Other
accession IDs
MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13836, MGD-MRK-13838, MGD-MRK-13917, MGD-MRK-13951, MGI:2138723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory