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Ren1 Gene Detail
Summary
  • Symbol
    Ren1
  • Name
    renin 1 structural
  • Synonyms
    Ren, Ren-1, Ren1c, Ren1d, Ren-A, Rn-1, Rnr
  • Feature Type
    protein coding gene
  • IDs
    MGI:97898
    NCBI Gene: 19701
  • Gene Overview
    MyGene.info: REN
Location & Maps
more
  • Sequence Map
    Chr1:133350510-133360325 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9816 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.91 cM
  • Mapping Data
    32 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    REN, renin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    REN, renin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HNFJ2
  • Links
    NCBI Gene ID: 5972
    neXtProt AC: NX_P00797

  • Chr Location
    1q32.1; chr1:204154816-204166337 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20151
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: REN
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human REN associations

Human Disease Mouse Models
       Hyperuricemic Nephropathy, Familial Juvenile, 2; HNFJ2   OMIM: 613092
Renal Tubular Dysgenesis; RTD   OMIM: 267430
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 10 alleles in 11 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    11
  • Transgenic
    5
  • Genomic Mutations
    3 involving Ren1
  • Incidental Mutations
Homozygous inactivation of this gene leads to postnatal lethality, reduced plasma renin level, decreased mean arterial pressure, and kidney defects such as atrophy, altered juxtaglomerular cell and macula densa morphology, polyuria, decreased urine osmolality, and reduced glomerular filtration rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021617 VEGA Gene Model | MGI Sequence Detail 9816 C57BL/6J ±  kb
transcript OTTMUST00000051330 VEGA | MGI Sequence Detail 1592 Not Applicable  
polypeptide OTTMUSP00000024128 VEGA | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    298 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 40
    Genomic 16
    cDNA 18
    Primer pair 4
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13836, MGD-MRK-13838, MGD-MRK-13917, MGD-MRK-13951, MGI:2138723
References
more
  • Summaries
    All 162
    Developmental Gene Expression 29
    Gene Ontology 8
    Phenotypes 81
  • Earliest
    J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
  • Latest
    J:233797 Kato H, et al., Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. PLoS One. 2015;10(6):e0129484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory