Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables endopeptidase activity. Involved in male gonad development and mesonephros development. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; hormone-mediated signaling pathway; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).