Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAB7A
  • Mouse genes Rab7
  • Rat genes Rab7a
  • Zfish genes rab7a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rab7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RAB7A	IDA		Human	PMID:18272684
Molecular Function	GO:0019003	GDP binding	Rab7a	IDA		Rat	PMID:16040606|RGD:4892340
Molecular Function	GO:0005525	GTP binding	RAB7A	IDA		Human	PMID:18272684
Molecular Function	GO:0005525	GTP binding	Rab7a	IDA		Rat	PMID:16040606|RGD:4892340
Molecular Function	GO:0003924	GTPase activity	RAB7A	IDA		Human	PMID:18272684
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q8NEB9	Human	PMID:14617358
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q99570	Human	PMID:14617358
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9UJC3	Human	PMID:15471887
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:15933719
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9BXW6	Human	PMID:16176980
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9Y4L5	Human	PMID:16925951
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:18272684
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:18787122
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9BQS8	Human	PMID:20100911
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q13286	Human	PMID:22261744
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:O75503	Human	PMID:22431521
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:P20339	Human	PMID:22431521
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:22431521
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96QK1	Human	PMID:24344282
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9UBQ0	Human	PMID:24344282
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:25500191
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q6ZNE9	Human	PMID:26416964
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:26911690
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9Y4G2	Human	PMID:27291868
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9Y4G2	Human	PMID:28325809
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96RL7	Human	PMID:30709847
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:30721249
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9BXW6	Human	PMID:30721249
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q02535	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q6ZR37	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q8WXF7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96NA2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9GZS3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9UNE7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9UNS2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q9Y4G2	Human	PMID:33452816
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:Q96JC1	Human	PMID:33947832
Molecular Function	GO:0005515	protein binding	RAB7A	IPI	UniProtKB:A6NDU8	Human	PMID:34432599
Molecular Function	GO:0005515	protein binding	Rab7	IPI	UniProtKB:Q9R1Q9	Mouse	MGI:MGI:5575464|PMID:22467241
Molecular Function	GO:0005515	protein binding	Rab7	IPI	UniProtKB:Q9D0C1	Mouse	MGI:MGI:4821079|PMID:12972561
Molecular Function	GO:0005515	protein binding	Rab7	IPI	UniProtKB:Q6DFW0	Mouse	MGI:MGI:5553382|PMID:24549040
Molecular Function	GO:0005515	protein binding	Rab7	IPI	UniProtKB:Q7TSI1	Mouse	MGI:MGI:5806241|PMID:27777970
Molecular Function	GO:0005515	protein binding	Rab7	IPI	MGI:MGI:1350931	Mouse	PMID:29712939
Molecular Function	GO:0005515	protein binding	Rab7	IPI	PR:Q6NVG5	Mouse	PMID:22275436
Molecular Function	GO:0005515	protein binding	Rab7	IPI	PR:Q9R0M3	Mouse	PMID:19368996
Molecular Function	GO:0005515	protein binding	Rab7	IPI	PR:Q5ND29	Mouse	PMID:22275436
Molecular Function	GO:0005515	protein binding	Rab7a	IPI	UniProtKB:P37727	Rat	PMID:15186776|RGD:8553294
Molecular Function	GO:0005515	protein binding	Rab7a	IPI	UniProtKB:Q08602	Rat	PMID:18756270|RGD:8554706
Molecular Function	GO:1905394	retromer complex binding	RAB7A	IMP		Human	PMID:27385586
Molecular Function	GO:0031267	small GTPase binding	Rab7a	IPI	RGD:619755	Rat	PMID:16040606|RGD:4892340
Cellular Component	GO:0097208	alveolar lamellar body	Rab7a	IDA		Rat	PMID:7868367|RGD:4892636
Cellular Component	GO:0005737	cytoplasm	Rab7	IDA		Mouse	PMID:18656450
Cellular Component	GO:0031410	cytoplasmic vesicle	Rab7a	IDA		Rat	PMID:16040606|RGD:4892340
Cellular Component	GO:0005829	cytosol	Rab7	IDA		Mouse	MGI:MGI:5689086|PMID:23708524
Cellular Component	GO:0005768	endosome	Rab7	IDA		Mouse	PMID:26582200
Cellular Component	GO:0010008	endosome membrane	RAB7A	IDA		Human	PMID:22431521
Cellular Component	GO:0010008	endosome membrane	RAB7A	IMP		Human	PMID:26911690
Cellular Component	GO:0070062	extracellular exosome	RAB7A	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RAB7A	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	RAB7A	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	Rab7	IDA		Mouse	PMID:11042173
Cellular Component	GO:0005770	late endosome	RAB7A	IDA		Human	PMID:18272684
Cellular Component	GO:0005770	late endosome	RAB7A	IDA		Human	PMID:14617358
Cellular Component	GO:0005770	late endosome	RAB7A	IDA		Human	PMID:15078902
Cellular Component	GO:0005770	late endosome	RAB7A	IDA		Human	PMID:17010938
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:27390154
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:25592972
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:23028046
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:15588329
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:20943658
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:19509052
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:35353806
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:11172003
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:24334765
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:24760869
Cellular Component	GO:0005770	late endosome	Rab7	IDA		Mouse	PMID:24035762
Cellular Component	GO:0005770	late endosome	Rab7a	IDA		Rat	PMID:19337031|RGD:4892338
Cellular Component	GO:0005770	late endosome	rab7a	IDA		Zfish	PMID:21976318
Cellular Component	GO:0031902	late endosome membrane	Rab7	IDA		Mouse	MGI:MGI:5689086|PMID:23708524
Cellular Component	GO:0005811	lipid droplet	Rab7	IDA		Mouse	MGI:MGI:5689086|PMID:23708524
Cellular Component	GO:0005765	lysosomal membrane	Rab7	IDA		Mouse	MGI:MGI:5689086|PMID:23708524
Cellular Component	GO:0005764	lysosome	RAB7A	IDA		Human	PMID:18272684
Cellular Component	GO:0005764	lysosome	RAB7A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	RAB7A	IDA		Human	PMID:15078902
Cellular Component	GO:0005764	lysosome	Rab7	IDA		Mouse	PMID:29712939
Cellular Component	GO:0005739	mitochondrion	RAB7A	IDA		Human	PMID:34432599
Cellular Component	GO:0045335	phagocytic vesicle	RAB7A	IDA		Human	PMID:21255211
Cellular Component	GO:0034045	phagophore assembly site membrane	Rab7	IDA		Mouse	MGI:MGI:5586797|PMID:19956673
Cellular Component	GO:0030672	synaptic vesicle membrane	Rab7a	EXP		Rat	PMID:20926670|RGD:13432355
Cellular Component	GO:0030672	synaptic vesicle membrane	Rab7a	IDA		Rat	PMID:20926670|RGD:13432355
Cellular Component	GO:0030672	synaptic vesicle membrane	Rab7a	IMP		Rat	PMID:20926670|RGD:13432355
Cellular Component	GO:0043195	terminal bouton	Rab7a	HDA		Rat	PMID:24876496|RGD:10047219
Biological Process	GO:0000045	autophagosome assembly	RAB7A	IMP		Human	PMID:19956673
Biological Process	GO:0045453	bone resorption	Rab7a	IMP		Rat	PMID:11514537|RGD:729760
Biological Process	GO:0045022	early endosome to late endosome transport	RAB7A	IMP		Human	PMID:14617358
Biological Process	GO:0016197	endosomal transport	rab7a	IDA		Zfish	PMID:26791407
Biological Process	GO:0008333	endosome to lysosome transport	RAB7A	IMP		Human	PMID:18272684
Biological Process	GO:0099638	endosome to plasma membrane protein transport	RAB7A	IMP		Human	PMID:33147445
Biological Process	GO:0007174	epidermal growth factor catabolic process	RAB7A	IMP		Human	PMID:18272684
Biological Process	GO:0051650	establishment of vesicle localization	Rab7	IMP		Mouse	PMID:29712939
Biological Process	GO:0046907	intracellular transport	RAB7A	IMP		Human	PMID:22042847
Biological Process	GO:0061724	lipophagy	Rab7	IMP		Mouse	MGI:MGI:5689086|PMID:23708524
Biological Process	GO:1903542	negative regulation of exosomal secretion	RAB7A	IMP		Human	PMID:26911690
Biological Process	GO:0090383	phagosome acidification	RAB7A	IMP		Human	PMID:21255211
Biological Process	GO:0090385	phagosome-lysosome fusion	RAB7A	IMP		Human	PMID:21255211
Biological Process	GO:1903543	positive regulation of exosomal secretion	RAB7A	IMP		Human	PMID:22660413
Biological Process	GO:0045732	positive regulation of protein catabolic process	RAB7A	IMP		Human	PMID:22072966
Biological Process	GO:0048524	positive regulation of viral process	RAB7A	IMP		Human	PMID:22072966
Biological Process	GO:0006622	protein targeting to lysosome	RAB7A	IMP		Human	PMID:22115783
Biological Process	GO:0022615	protein to membrane docking	RAB7A	IDA		Human	PMID:24344282
Biological Process	GO:0009617	response to bacterium	RAB7A	IMP		Human	PMID:22042847
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	RAB7A	IMP		Human	PMID:19531583
Biological Process	GO:0019076	viral release from host cell	RAB7A	IMP		Human	PMID:22072966

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern