Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTGS2
  • Mouse genes Ptgs2
  • Rat genes Ptgs2
  • Zfish genes ptgs2a,ptgs2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptgs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	PTGS2	IPI	UniProtKB:P29477	Human	PMID:16373578
Molecular Function	GO:0020037	heme binding	Ptgs2	IDA		Mouse	MGI:MGI:5315361|PMID:12925531
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Ptgs2	IDA		Rat	PMID:8203528|RGD:1642604
Molecular Function	GO:0004601	peroxidase activity	ptgs2a	IDA		Zfish	PMID:17112475
Molecular Function	GO:0004601	peroxidase activity	ptgs2b	IDA		Zfish	PMID:17112475
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	PTGS2	IDA		Human	PMID:1380156
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	PTGS2	IDA		Human	PMID:16373578
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	PTGS2	IDA		Human	PMID:7592599
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	PTGS2	IDA		Human	PMID:7947975
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	Ptgs2	IDA		Mouse	MGI:MGI:5315361|PMID:12925531
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	Ptgs2	IDA		Mouse	PMID:1419907
Molecular Function	GO:0005515	protein binding	PTGS2	IPI	UniProtKB:Q03135	Human	PMID:24089527
Molecular Function	GO:0005515	protein binding	PTGS2	IPI	UniProtKB:Q9BUN8	Human	PMID:24089527
Molecular Function	GO:0005515	protein binding	PTGS2	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ptgs2	IPI	UniProtKB:Q9Z0J4	Mouse	MGI:MGI:3807118|PMID:18650379
Molecular Function	GO:0005515	protein binding	Ptgs2	IPI	RGD:2281	Rat	PMID:16479074|RGD:1600265
Molecular Function	GO:0042803	protein homodimerization activity	Ptgs2	IPI	UniProtKB:Q05769	Mouse	MGI:MGI:5315361|PMID:12925531
Cellular Component	GO:0005901	caveola	Ptgs2	IDA		Rat	PMID:16479074|RGD:1600265
Cellular Component	GO:0005737	cytoplasm	PTGS2	IDA		Human	PMID:14511332
Cellular Component	GO:0005737	cytoplasm	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Cellular Component	GO:0005737	cytoplasm	Ptgs2	IDA		Mouse	PMID:12021206
Cellular Component	GO:0005737	cytoplasm	Ptgs2	IDA		Rat	PMID:16479074|RGD:1600265
Cellular Component	GO:0005737	cytoplasm	Ptgs2	IDA		Rat	PMID:20950588|RGD:8554513
Cellular Component	GO:0005783	endoplasmic reticulum	PTGS2	IDA		Human	PMID:24089527
Cellular Component	GO:0043005	neuron projection	PTGS2	IDA		Human	PMID:12355421
Cellular Component	GO:0043005	neuron projection	Ptgs2	IDA		Mouse	PMID:12355421
Cellular Component	GO:0005637	nuclear inner membrane	PTGS2	IDA		Human	PMID:9545330
Cellular Component	GO:0005637	nuclear inner membrane	Ptgs2	IDA		Mouse	MGI:MGI:6393059|PMID:9545330
Cellular Component	GO:0005640	nuclear outer membrane	PTGS2	IDA		Human	PMID:9545330
Cellular Component	GO:0005640	nuclear outer membrane	Ptgs2	IDA		Mouse	MGI:MGI:6393059|PMID:9545330
Cellular Component	GO:0032991	protein-containing complex	Ptgs2	IDA		Rat	PMID:16479074|RGD:1600265
Biological Process	GO:0007568	aging	Ptgs2	IEP		Rat	PMID:25546515|RGD:11566048
Biological Process	GO:0042640	anagen	Ptgs2	IMP		Mouse	PMID:15713628
Biological Process	GO:0001525	angiogenesis	Ptgs2	IMP		Rat	PMID:21273371|RGD:5135049
Biological Process	GO:0030282	bone mineralization	Ptgs2	IMP		Rat	PMID:18519738|RGD:8554572
Biological Process	GO:0050873	brown fat cell differentiation	Ptgs2	IMP		Mouse	MGI:MGI:4454608|PMID:20448152
Biological Process	GO:0098869	cellular oxidant detoxification	ptgs2b	IDA		Zfish	PMID:17112475|ZFIN:ZDB-PUB-061205-4
Biological Process	GO:0098869	cellular oxidant detoxification	ptgs2a	IDA		Zfish	PMID:17112475|ZFIN:ZDB-PUB-061205-4
Biological Process	GO:0071318	cellular response to ATP	Ptgs2	IEP		Rat	PMID:21678415|RGD:5135027
Biological Process	GO:0071498	cellular response to fluid shear stress	Ptgs2	IDA		Mouse	PMID:24841674
Biological Process	GO:0034605	cellular response to heat	Ptgs2	IEP		Rat	PMID:22777528|RGD:11567213
Biological Process	GO:0071456	cellular response to hypoxia	PTGS2	IEP		Human	PMID:21296955
Biological Process	GO:0071284	cellular response to lead ion	Ptgs2	IEP		Rat	PMID:25193092|RGD:13207490
Biological Process	GO:0071260	cellular response to mechanical stimulus	Ptgs2	IEP		Rat	PMID:21051526|RGD:5135055
Biological Process	GO:0071471	cellular response to non-ionic osmotic stress	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Biological Process	GO:0071407	cellular response to organic cyclic compound	ptgs2a	IDA		Zfish	PMID:17112475
Biological Process	GO:0071407	cellular response to organic cyclic compound	ptgs2b	IDA		Zfish	PMID:17112475
Biological Process	GO:0071417	cellular response to organonitrogen compound	Ptgs2	IEP		Rat	PMID:22306367|RGD:5688265
Biological Process	GO:0019371	cyclooxygenase pathway	PTGS2	IDA		Human	PMID:1380156
Biological Process	GO:0019371	cyclooxygenase pathway	PTGS2	IDA		Human	PMID:7592599
Biological Process	GO:0019371	cyclooxygenase pathway	PTGS2	IDA		Human	PMID:7947975
Biological Process	GO:0019371	cyclooxygenase pathway	Ptgs2	IDA		Mouse	MGI:MGI:5315361|PMID:12925531
Biological Process	GO:0019371	cyclooxygenase pathway	Ptgs2	IDA		Mouse	PMID:1419907
Biological Process	GO:0046697	decidualization	Ptgs2	IMP	MGI:MGI:1857239	Mouse	PMID:10385625
Biological Process	GO:0046697	decidualization	Ptgs2	IMP		Rat	PMID:17485303|RGD:2300266
Biological Process	GO:0007566	embryo implantation	Ptgs2	IMP	MGI:MGI:1857239	Mouse	PMID:10385625
Biological Process	GO:0007566	embryo implantation	Ptgs2	IMP		Rat	PMID:17485303|RGD:2300266
Biological Process	GO:1990402	embryonic liver development	ptgs2a	IMP	ZFIN:ZDB-MRPHLNO-050722-5,ZFIN:ZDB-MRPHLNO-050722-6	Zfish	PMID:24530296
Biological Process	GO:0031017	exocrine pancreas development	ptgs2a	IMP	ZFIN:ZDB-MRPHLNO-050722-5,ZFIN:ZDB-MRPHLNO-050722-6	Zfish	PMID:24530296
Biological Process	GO:0042633	hair cycle	Ptgs2	IEP		Rat	PMID:19180200|RGD:5135217
Biological Process	GO:0006954	inflammatory response	Ptgs2	IMP		Rat	PMID:17701021|RGD:1642601
Biological Process	GO:0007612	learning	Ptgs2	IMP		Rat	PMID:21701788|RGD:5688147
Biological Process	GO:0035633	maintenance of blood-brain barrier	Ptgs2	IMP		Rat	PMID:17704356|RGD:2325928
Biological Process	GO:0007613	memory	Ptgs2	IMP		Rat	PMID:18540883|RGD:2300227
Biological Process	GO:0043066	negative regulation of apoptotic process	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Biological Process	GO:0051926	negative regulation of calcium ion transport	Ptgs2	IMP		Rat	PMID:17766482|RGD:1642599
Biological Process	GO:0045786	negative regulation of cell cycle	Ptgs2	IGI	RGD:69116	Rat	PMID:11756433|RGD:619537
Biological Process	GO:0045786	negative regulation of cell cycle	Ptgs2	IGI	RGD:732911	Rat	PMID:11756433|RGD:619537
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ptgs2	IDA		Rat	PMID:11756433|RGD:619537
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Biological Process	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Ptgs2	IMP		Rat	PMID:21051526|RGD:5135055
Biological Process	GO:0032227	negative regulation of synaptic transmission, dopaminergic	Ptgs2	IMP		Rat	PMID:18764909|RGD:2300272
Biological Process	GO:0030728	ovulation	Ptgs2	IMP		Rat	PMID:17485303|RGD:2300266
Biological Process	GO:0043065	positive regulation of apoptotic process	Ptgs2	IMP		Rat	PMID:17828456|RGD:1642595
Biological Process	GO:0043065	positive regulation of apoptotic process	Ptgs2	IMP		Rat	PMID:22306367|RGD:5688265
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Ptgs2	IMP		Mouse	MGI:MGI:4454608|PMID:20448152
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	Ptgs2	IMP		Rat	PMID:9630216|RGD:5135054
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ptgs2	IMP		Rat	PMID:22165968|RGD:5687745
Biological Process	GO:0031622	positive regulation of fever generation	Ptgs2	IDA		Mouse	MGI:MGI:4413614|PMID:19940926
Biological Process	GO:0031622	positive regulation of fever generation	Ptgs2	IDA		Rat	PMID:19940926|RGD:8554070
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	Ptgs2	IMP		Rat	PMID:9630216|RGD:5135054
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Ptgs2	IMP		Rat	PMID:9630216|RGD:5135054
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Biological Process	GO:0090362	positive regulation of platelet-derived growth factor production	Ptgs2	IMP		Rat	PMID:9630216|RGD:5135054
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	Ptgs2	IMP		Mouse	MGI:MGI:5474549|PMID:21716255
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Ptgs2	IMP		Rat	PMID:20472710|RGD:4891488
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Ptgs2	IMP		Rat	PMID:17645304|RGD:1642591
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Ptgs2	IMP		Rat	PMID:18480553|RGD:2300247
Biological Process	GO:0031915	positive regulation of synaptic plasticity	Ptgs2	IMP		Rat	PMID:18540883|RGD:2300227
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Ptgs2	IMP		Rat	PMID:18764909|RGD:2300272
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	Ptgs2	IMP		Rat	PMID:9630216|RGD:5135054
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	Ptgs2	IMP		Rat	PMID:9630216|RGD:5135054
Biological Process	GO:0045907	positive regulation of vasoconstriction	Ptgs2	IMP		Rat	PMID:17245358|RGD:1625725
Biological Process	GO:0045907	positive regulation of vasoconstriction	Ptgs2	IMP		Rat	PMID:18456673|RGD:2300248
Biological Process	GO:0048793	pronephros development	ptgs2a	IMP	ZFIN:ZDB-MRPHLNO-050722-5	Zfish	PMID:27996936
Biological Process	GO:0001516	prostaglandin biosynthetic process	PTGS2	IDA		Human	PMID:27642067
Biological Process	GO:0001516	prostaglandin biosynthetic process	Ptgs2	IDA		Mouse	MGI:MGI:5315361|PMID:12925531
Biological Process	GO:0001516	prostaglandin biosynthetic process	Ptgs2	IMP		Rat	PMID:17673564|RGD:2300259
Biological Process	GO:0032310	prostaglandin secretion	Ptgs2	IMP		Mouse	PMID:32484881
Biological Process	GO:0008217	regulation of blood pressure	Ptgs2	IMP	MGI:MGI:2158457	Mouse	PMID:12093889
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs2	IGI	MGI:MGI:88039	Mouse	PMID:11245490
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs2	IGI	MGI:MGI:88039	Mouse	PMID:10987272
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs2	IGI	MGI:MGI:88039	Mouse	PMID:11809702
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs2	IGI	MGI:MGI:88039	Mouse	PMID:8945508
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs2	IGI	MGI:MGI:88039	Mouse	PMID:10783317
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs2	IGI	MGI:MGI:894293	Mouse	PMID:11809702
Biological Process	GO:0150077	regulation of neuroinflammatory response	Ptgs2	IDA		Mouse	MGI:MGI:6158194|PMID:29662056
Biological Process	GO:1990776	response to angiotensin	Ptgs2	IEP		Rat	PMID:21311042|RGD:13207486
Biological Process	GO:0034097	response to cytokine	Ptgs2	IMP		Rat	PMID:18383135|RGD:2300282
Biological Process	GO:0032355	response to estradiol	Ptgs2	IEP		Rat	PMID:18310519|RGD:2300251
Biological Process	GO:0070542	response to fatty acid	Ptgs2	IEP		Rat	PMID:16983392|RGD:5688222
Biological Process	GO:0009750	response to fructose	Ptgs2	IEP		Rat	PMID:17883899|RGD:1642586
Biological Process	GO:0051384	response to glucocorticoid	Ptgs2	IEP		Rat	PMID:18657281|RGD:2300273
Biological Process	GO:0032496	response to lipopolysaccharide	Ptgs2	IMP		Rat	PMID:17766482|RGD:1642599
Biological Process	GO:0010226	response to lithium ion	Ptgs2	IEP		Rat	PMID:12232777|RGD:5688238
Biological Process	GO:0010042	response to manganese ion	Ptgs2	IEP		Rat	PMID:17827730|RGD:1642596
Biological Process	GO:0009624	response to nematode	Ptgs2	IMP		Mouse	PMID:32484881
Biological Process	GO:0014070	response to organic cyclic compound	Ptgs2	IEP		Rat	PMID:18769055|RGD:2300271
Biological Process	GO:0010033	response to organic substance	Ptgs2	IEP		Rat	PMID:18373278|RGD:2300283
Biological Process	GO:0010243	response to organonitrogen compound	Ptgs2	IEP		Rat	PMID:11211925|RGD:2300269
Biological Process	GO:0009314	response to radiation	Ptgs2	IEP		Rat	PMID:18606213|RGD:5135219
Biological Process	GO:0048545	response to steroid hormone	ptgs2a	IEP		Zfish	PMID:28265462
Biological Process	GO:0034612	response to tumor necrosis factor	Ptgs2	IEP		Rat	PMID:17704356|RGD:2325928
Biological Process	GO:0033280	response to vitamin D	Ptgs2	IEP		Rat	PMID:18348265|RGD:2300284
Biological Process	GO:0009410	response to xenobiotic stimulus	Ptgs2	IEP		Rat	PMID:17883899|RGD:1642586
Biological Process	GO:0009410	response to xenobiotic stimulus	Ptgs2	IEP		Rat	PMID:29091898|RGD:15090820
Biological Process	GO:0019233	sensory perception of pain	Ptgs2	IMP		Rat	PMID:21362433|RGD:5508227

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern