Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PSENEN
  • Mouse genes Psenen
  • Rat genes Psenen
  • Zfish genes psenen
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Psenen

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061133	endopeptidase activator activity	PSENEN	IMP		Human	PMID:12522139
Molecular Function	GO:0061133	endopeptidase activator activity	PSENEN	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Molecular Function	GO:0061133	endopeptidase activator activity	Psenen	IMP		Mouse	MGI:MGI:6478051|PMID:12522139
Molecular Function	GO:0019899	enzyme binding	PSENEN	IPI	UniProtKB:P49768	Human	PMID:12522139
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P49768	Human	PMID:15322109
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q92542	Human	PMID:15322109
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P49755	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q92542	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q92542	Human	PMID:18201567
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P02792	Human	PMID:23685131
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P49768	Human	PMID:30559186
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P49768-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q12908	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q9BUF7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:P06241	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PSENEN	IPI	UniProtKB:Q15438	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Psenen	IPI	PR:Q8BVF7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psenen	IPI	PR:Q61144	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psenen	IPI	PR:P49769	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psenen	IPI	PR:P49769	Mouse	PMID:21597003
Cellular Component	GO:0005783	endoplasmic reticulum	PSENEN	IDA		Human	PMID:15274632
Cellular Component	GO:0070765	gamma-secretase complex	PSENEN	IPI		Human	PMID:26280335
Cellular Component	GO:0070765	gamma-secretase complex	PSENEN	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Cellular Component	GO:0070765	gamma-secretase complex	PSENEN	IDA		Human	PMID:25043039
Cellular Component	GO:0070765	gamma-secretase complex	PSENEN	IDA		Human	PMID:26280335
Cellular Component	GO:0070765	gamma-secretase complex	Psenen	IDA		Mouse	PMID:16641999
Cellular Component	GO:0070765	gamma-secretase complex	Psenen	IDA		Mouse	PMID:16371134
Cellular Component	GO:0005794	Golgi apparatus	PSENEN	IDA		Human	PMID:15274632
Cellular Component	GO:0016020	membrane	PSENEN	IDA		Human	PMID:25043039
Cellular Component	GO:0016020	membrane	PSENEN	IDA		Human	PMID:26280335
Cellular Component	GO:0005739	mitochondrion	Psenen	IDA		Rat	PMID:15456764|RGD:1358417
Cellular Component	GO:0005886	plasma membrane	PSENEN	IDA		Human	PMID:15274632
Cellular Component	GO:0042734	presynaptic membrane	Psenen	IDA		Rat	PMID:20126630|RGD:13702254
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSENEN	IMP		Human	PMID:12660785
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSENEN	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSENEN	IDA		Human	PMID:15274632
Biological Process	GO:0042982	amyloid precursor protein metabolic process	PSENEN	IDA		Human	PMID:25043039
Biological Process	GO:0042982	amyloid precursor protein metabolic process	PSENEN	IDA		Human	PMID:26280335
Biological Process	GO:0034205	amyloid-beta formation	PSENEN	IMP		Human	PMID:12660785
Biological Process	GO:0034205	amyloid-beta formation	PSENEN	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0034205	amyloid-beta formation	PSENEN	IMP		Human	PMID:25043039
Biological Process	GO:0034205	amyloid-beta formation	PSENEN	IMP		Human	PMID:26280335
Biological Process	GO:0048066	developmental pigmentation	psenen	IMP	ZFIN:ZDB-MRPHLNO-060331-1	Zfish	PMID:28287404
Biological Process	GO:0048066	developmental pigmentation	psenen	IMP	ZFIN:ZDB-MRPHLNO-060331-2	Zfish	PMID:28287404
Biological Process	GO:0097324	melanocyte migration	psenen	IMP	ZFIN:ZDB-MRPHLNO-060331-1	Zfish	PMID:28287404
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	PSENEN	IDA		Human	PMID:15274632
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	PSENEN	IDA		Human	PMID:15274632
Biological Process	GO:0043066	negative regulation of apoptotic process	psenen	IMP	ZFIN:ZDB-MRPHLNO-060331-1	Zfish	PMID:16507571
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	psenen	IMP	ZFIN:ZDB-MRPHLNO-060331-1	Zfish	PMID:16464238
Biological Process	GO:0007220	Notch receptor processing	Psenen	IMP		Mouse	PMID:20130175
Biological Process	GO:0043085	positive regulation of catalytic activity	PSENEN	IDA		Human	PMID:15274632
Biological Process	GO:0010950	positive regulation of endopeptidase activity	PSENEN	IMP		Human	PMID:12522139
Biological Process	GO:0010950	positive regulation of endopeptidase activity	PSENEN	IMP		Human	PMID:12660785
Biological Process	GO:0010950	positive regulation of endopeptidase activity	PSENEN	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0010950	positive regulation of endopeptidase activity	Psenen	IMP		Mouse	MGI:MGI:6478051|PMID:12522139
Biological Process	GO:0010950	positive regulation of endopeptidase activity	Psenen	IMP		Mouse	MGI:MGI:6392999|PMID:12660785
Biological Process	GO:0016485	protein processing	PSENEN	IMP		Human	PMID:12522139
Biological Process	GO:0016485	protein processing	PSENEN	IMP		Human	PMID:12660785
Biological Process	GO:0016485	protein processing	PSENEN	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0016485	protein processing	PSENEN	IDA		Human	PMID:15274632
Biological Process	GO:0016485	protein processing	Psenen	IMP		Mouse	MGI:MGI:6392999|PMID:12660785
Biological Process	GO:0016485	protein processing	Psenen	IMP		Mouse	MGI:MGI:6478051|PMID:12522139

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern