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Psenen
Gene Detail
Symbol

Name
ID
Psenen
presenilin enhancer 2 homolog (C. elegans)
MGI:1913590
Synonyms
1700023M09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
18.60 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:30561868-30563184 bp, - strand
From Ensembl annotation of GRCm38

  1317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSENEN
Gene Tree: Psenen

Human
homologs
PSENEN, presenilin enhancer gamma secretase subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55851
neXtProt AC: NX_Q9NZ42

Human Synonyms: MDS033, MSTP064, PEN2, PEN-2

Human Chr (Location): 19q13.12; chr19:35745577-35747155 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PSENEN

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in lethality before weaning.
 
Interactions
Psenen interacts with 24 markers (Mir30c-1, Mir30c-2, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process membrane protein ectodomain proteolysis, Notch receptor processing, ...
Component endoplasmic reticulum, gamma-secretase complex, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(111)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psenen ; ZFIN psenen    NEW 
Molecular
reagents
All nucleic(111) cDNA(111)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000036835 (Evidence)
Entrez Gene 66340 (Evidence)
UniGene 86557
DFCI TC1576472
NIA Mouse Gene Index U028389, U054628, U056137
Consensus CDS Project CCDS21099.1
International Mouse Phenotyping Consortium Status Psenen
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036835 Ensembl Gene Model | MGI Sequence Detail 1317 C57BL/6J ±  kb
transcript ENSMUST00000043898 Ensembl | MGI Sequence Detail 648 Not Applicable 
polypeptide ENSMUSP00000044682 Ensembl | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Protein Ontology PR:000013346 gamma-secretase subunit PEN-2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219929 Xia D, et al., Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Neuron. 2015 Mar 4;85(5):967-81
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory