Psenen
Gene Detail

Symbol Name ID

Psenen presenilin enhancer 2 homolog (C. elegans) MGI:1913590

Synonyms

1700023M09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

18.60 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:30561868-30563184 bp, - strand From Ensembl annotation of GRCm38   1317 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Psenen ± 2 cM)

Gene Tree: Psenen

Human ortholog

PSENEN presenilin enhancer 2 homolog (C. elegans) NCBI Gene ID 55851
Human Synonyms: MSTP064, PEN2, PEN-2
Human Chr19:36236494-36237903 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PSENEN (1)

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)
 

Homozygous mutation of this gene results in lethality before weaning.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	membrane protein ectodomain proteolysis, Notch receptor processing, ...
Component	endoplasmic reticulum, Golgi apparatus, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(111)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(111) cDNA(111)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000036835 (Evidence)
Entrez Gene	66340 (Evidence)
UniGene	86557
DFCI	TC1576472
NIA Mouse Gene Index	U028389, U054628, U056137
Consensus CDS Project	CCDS21099.1
International Mouse Knockout Project Status	Psenen

Sequences

Length	Strain/Species
genomic	ENSMUSG00000036835	Ensembl Gene Model | MGI Sequence Detail	1317	C57BL/6J
transcript	ENSMUST00000043898	Ensembl | MGI Sequence Detail	648	Not Applicable
polypeptide	ENSMUSP00000044682	Ensembl | MGI Sequence Detail	101	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019379	Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Protein Ontology	PR:000013346	gamma-secretase subunit PEN-2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)