Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPP3R1
  • Mouse genes Ppp3r1
  • Rat genes Ppp3r1
  • Zfish genes ppp3r1a,ppp3r1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppp3r1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016018	cyclosporin A binding	PPP3R1	IDA		Human	PMID:12218175
Molecular Function	GO:0016018	cyclosporin A binding	PPP3R1	IDA		Human	PMID:12357034
Molecular Function	GO:0019899	enzyme binding	Ppp3r1	IPI	UniProtKB:P63328	Mouse	MGI:MGI:4821678|PMID:20639889
Molecular Function	GO:0019902	phosphatase binding	PPP3R1	IPI	UniProtKB:P16298	Human	PMID:26794871
Molecular Function	GO:0019902	phosphatase binding	PPP3R1	IPI	UniProtKB:Q08209	Human	PMID:27974827
Molecular Function	GO:0019902	phosphatase binding	Ppp3r1	IPI	UniProtKB:P63328	Mouse	MGI:MGI:6119999|PMID:26794871
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppp3r1	IMP	MGI:MGI:3043986	Mouse	PMID:11439183
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppp3r1	IDA		Rat	PMID:12135494|RGD:729536
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:P62937,UniProtKB:Q08209	Human	PMID:12218175
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:P62937,UniProtKB:Q08209	Human	PMID:12357034
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:P53805	Human	PMID:12809556
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q99683	Human	PMID:16648474
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209	Human	PMID:19896943
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-1	Human	PMID:22343722
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-1	Human	PMID:23468591
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-1	Human	PMID:24954618
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-2	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:P48454	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:P48454	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q96N06	Human	PMID:34446558
Molecular Function	GO:0005515	protein binding	PPP3R1	IPI	UniProtKB:Q08209	Human	PMID:8524402
Molecular Function	GO:0005515	protein binding	Ppp3r1	IPI	UniProtKB:Q99828|UniProtKB:Q99828	Mouse	MGI:MGI:4821678|PMID:20639889
Molecular Function	GO:0005515	protein binding	Ppp3r1	IPI	UniProtKB:O35099	Mouse	MGI:MGI:3625665|PMID:16648474
Molecular Function	GO:0005515	protein binding	Ppp3r1	IPI	UniProtKB:Q9Z0F4|UniProtKB:Q9Z0F4	Mouse	MGI:MGI:4821678|PMID:20639889
Molecular Function	GO:0005515	protein binding	Ppp3r1	IPI	RGD:620103	Rat	PMID:15120593|RGD:1579942
Molecular Function	GO:0019904	protein domain specific binding	PPP3R1	IPI	UniProtKB:Q99828	Human	PMID:20639889
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:12218175
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:12357034
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:22343722
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:22688515
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:23468591
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:26794871
Cellular Component	GO:0005955	calcineurin complex	PPP3R1	IDA		Human	PMID:27974827
Cellular Component	GO:0005955	calcineurin complex	Ppp3r1	IDA		Mouse	MGI:MGI:6119999|PMID:26794871
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3r1	IDA		Mouse	PMID:11733061
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3r1	IMP		Mouse	PMID:11733061
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3r1	IDA		Mouse	PMID:24413018
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3r1	EXP		Mouse	PMID:24413018
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3r1	IDA		Mouse	PMID:23825400
Cellular Component	GO:0098978	glutamatergic synapse	Ppp3r1	IMP		Mouse	PMID:23825400
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Ppp3r1	IDA		Mouse	PMID:23825400
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Ppp3r1	IMP		Mouse	PMID:23825400
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Ppp3r1	IMP		Mouse	PMID:20797538
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Ppp3r1	IDA		Mouse	PMID:20797538
Cellular Component	GO:0098794	postsynapse	Ppp3r1	IDA		Mouse	MGI:MGI:4848266|PMID:20797538
Cellular Component	GO:0042383	sarcolemma	Ppp3r1	IDA		Mouse	MGI:MGI:4821678|PMID:20639889
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ppp3r1	IMP		Mouse	PMID:11733061
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ppp3r1	IDA		Mouse	PMID:11733061
Cellular Component	GO:0045202	synapse	Ppp3r1	EXP		Mouse	PMID:24413018
Cellular Component	GO:0045202	synapse	Ppp3r1	IDA		Mouse	PMID:24413018
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Ppp3r1	IMP	MGI:MGI:3043986	Mouse	PMID:11439183
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	PPP3R1	IDA		Human	PMID:22688515
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Ppp3r1	IGI	MGI:MGI:103296	Mouse	PMID:19179536
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	Ppp3r1	IGI	MGI:MGI:1920431	Mouse	PMID:19179536
Biological Process	GO:0001837	epithelial to mesenchymal transition	Ppp3r1	IMP	MGI:MGI:3044031	Mouse	PMID:15339668
Biological Process	GO:0007507	heart development	Ppp3r1	IMP	MGI:MGI:3044031	Mouse	PMID:15339668
Biological Process	GO:0060487	lung epithelial cell differentiation	Ppp3r1	IMP	MGI:MGI:3044031	Mouse	PMID:16998587
Biological Process	GO:0022011	myelination in peripheral nervous system	Ppp3r1	IMP	MGI:MGI:3044031	Mouse	PMID:19179536
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PPP3R1	IDA		Human	PMID:22688515
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ppp3r1	IDA		Mouse	PMID:11733061
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ppp3r1	IMP		Mouse	PMID:11733061
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ppp3r1	IDA		Mouse	PMID:20797538
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ppp3r1	IMP		Mouse	PMID:20797538
Biological Process	GO:0006470	protein dephosphorylation	Ppp3r1	IMP	MGI:MGI:3043986	Mouse	PMID:11439183
Biological Process	GO:0006470	protein dephosphorylation	Ppp3r1	IDA		Rat	PMID:12135494|RGD:729536
Biological Process	GO:0006606	protein import into nucleus	Ppp3r1	IMP	MGI:MGI:3043986	Mouse	PMID:11439183
Biological Process	GO:0034504	protein localization to nucleus	Ppp3r1	IMP	MGI:MGI:3044022	Mouse	PMID:16998587
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Ppp3r1	IMP		Mouse	PMID:11733061
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Ppp3r1	IDA		Mouse	PMID:11733061
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Ppp3r1	IMP		Mouse	PMID:23825400
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Ppp3r1	IDA		Mouse	PMID:23825400
Biological Process	GO:0014044	Schwann cell development	Ppp3r1	IMP	MGI:MGI:3044031	Mouse	PMID:19179536

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern