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Term Detail
GO term:calcineurin-NFAT signaling cascade
Synonym: calcineurin-NFAT signaling pathway
Synonym: calcineurin-NFAT signalling pathway
GO id:GO:0033173
Definition:Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
Number of paths to term: 18

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-asecond-messenger-mediated signaling
                                                                is-acalcium-mediated signaling
                                                                        is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                        is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                                negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                                positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                                regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                        is-acalcium-mediated signaling using extracellular calcium source
                                                                        is-acalcium-mediated signaling using intracellular calcium source
                                                                        is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                        negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                        positively-regulatespositive regulation of calcium-mediated signaling +
                                                                        is-apositive regulation of cerebellar granule cell migration by calcium
                                                                        regulatesregulation of calcium-mediated signaling +
                                                                        is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                        is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                        is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-asecond-messenger-mediated signaling
                                                                is-ainositol phosphate-mediated signaling
                                                                        is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                                negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                                positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                                regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-acalcium-mediated signaling
                                                                is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                is-acalcium-mediated signaling using extracellular calcium source
                                                                is-acalcium-mediated signaling using intracellular calcium source
                                                                is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                positively-regulatespositive regulation of calcium-mediated signaling +
                                                                is-apositive regulation of cerebellar granule cell migration by calcium
                                                                regulatesregulation of calcium-mediated signaling +
                                                                is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-ainositol phosphate-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-acalcium-mediated signaling
                                                                is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                is-acalcium-mediated signaling using extracellular calcium source
                                                                is-acalcium-mediated signaling using intracellular calcium source
                                                                is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                positively-regulatespositive regulation of calcium-mediated signaling +
                                                                is-apositive regulation of cerebellar granule cell migration by calcium
                                                                regulatesregulation of calcium-mediated signaling +
                                                                is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-ainositol phosphate-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-asecond-messenger-mediated signaling
                                                                is-acalcium-mediated signaling
                                                                        is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                        is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                                negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                                positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                                regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                        is-acalcium-mediated signaling using extracellular calcium source
                                                                        is-acalcium-mediated signaling using intracellular calcium source
                                                                        is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                        negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                        positively-regulatespositive regulation of calcium-mediated signaling +
                                                                        is-apositive regulation of cerebellar granule cell migration by calcium
                                                                        regulatesregulation of calcium-mediated signaling +
                                                                        is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                        is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                        is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-asecond-messenger-mediated signaling
                                                                is-ainositol phosphate-mediated signaling
                                                                        is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                                negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                                positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                                regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-acalcium-mediated signaling
                                                                is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                is-acalcium-mediated signaling using extracellular calcium source
                                                                is-acalcium-mediated signaling using intracellular calcium source
                                                                is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                positively-regulatespositive regulation of calcium-mediated signaling +
                                                                is-apositive regulation of cerebellar granule cell migration by calcium
                                                                regulatesregulation of calcium-mediated signaling +
                                                                is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-ainositol phosphate-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-acalcium-mediated signaling
                                                                is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                is-acalcium-mediated signaling using extracellular calcium source
                                                                is-acalcium-mediated signaling using intracellular calcium source
                                                                is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                positively-regulatespositive regulation of calcium-mediated signaling +
                                                                is-apositive regulation of cerebellar granule cell migration by calcium
                                                                regulatesregulation of calcium-mediated signaling +
                                                                is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-ainositol phosphate-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-acalcium-mediated signaling
                                                                is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                is-acalcium-mediated signaling using extracellular calcium source
                                                                is-acalcium-mediated signaling using intracellular calcium source
                                                                is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                positively-regulatespositive regulation of calcium-mediated signaling +
                                                                is-apositive regulation of cerebellar granule cell migration by calcium
                                                                regulatesregulation of calcium-mediated signaling +
                                                                is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-ainositol phosphate-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-acalcium-mediated signaling
                                                                is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                is-acalcium-mediated signaling using extracellular calcium source
                                                                is-acalcium-mediated signaling using intracellular calcium source
                                                                is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                positively-regulatespositive regulation of calcium-mediated signaling +
                                                                is-apositive regulation of cerebellar granule cell migration by calcium
                                                                regulatesregulation of calcium-mediated signaling +
                                                                is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-asecond-messenger-mediated signaling
                                                        is-ainositol phosphate-mediated signaling
                                                                is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                        negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                        positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                        regulatesregulation of calcineurin-NFAT signaling cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-asecond-messenger-mediated signaling
                                                                is-acalcium-mediated signaling
                                                                        is-aactivation of phospholipase A2 activity by calcium-mediated signaling
                                                                        is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                                negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                                positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                                regulatesregulation of calcineurin-NFAT signaling cascade +
                                                                        is-acalcium-mediated signaling using extracellular calcium source
                                                                        is-acalcium-mediated signaling using intracellular calcium source
                                                                        is-acytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration
                                                                        negatively-regulatesnegative regulation of calcium-mediated signaling +
                                                                        positively-regulatespositive regulation of calcium-mediated signaling +
                                                                        is-apositive regulation of cerebellar granule cell migration by calcium
                                                                        regulatesregulation of calcium-mediated signaling +
                                                                        is-aregulation of cardiac muscle contraction by calcium ion signaling +
                                                                        is-aregulation of skeletal muscle contraction by calcium ion signaling +
                                                                        is-aregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-asecond-messenger-mediated signaling
                                                                is-ainositol phosphate-mediated signaling
                                                                        is-acalcineurin-NFAT signaling cascade [GO:0033173] (14 genes, 18 annotations)
                                                                                negatively-regulatesnegative regulation of calcineurin-NFAT signaling cascade
                                                                                positively-regulatespositive regulation of calcineurin-NFAT signaling cascade
                                                                                regulatesregulation of calcineurin-NFAT signaling cascade +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory