Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PPP2CB
  • Mouse genes Ppp2cb
  • Rat genes Ppp2cb
  • Zfish genes ppp2cb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ppp2cb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Ppp2cb	IDA		Rat	PMID:9792806|RGD:8554494
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q9Y2T1	Human	PMID:10698523
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:O75663	Human	PMID:16085932
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:P78318	Human	PMID:18782753
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q5VSL9	Human	PMID:18782753
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:P78318	Human	PMID:19156129
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q13642-2	Human	PMID:20969868
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:P26651	Human	PMID:21784977
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q5VSL9	Human	PMID:25531779
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:P78318	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q5VSL9	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:O75663	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:P78318	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q5VSL9	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:Q06787-7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PPP2CB	IPI	UniProtKB:P78318	Human	PMID:9647778
Molecular Function	GO:0005515	protein binding	Ppp2cb	IPI	PR:P10417	Mouse	PMID:16717086
Molecular Function	GO:0005515	protein binding	Ppp2cb	IPI	PR:O35627	Mouse	PMID:12885400
Molecular Function	GO:0005515	protein binding	Ppp2cb	IPI	PR:P06537	Mouse	PMID:12885400
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Ppp2cb	IMP		Rat	PMID:10640627|RGD:13464259
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Ppp2cb	IDA		Rat	PMID:11884620|RGD:729591
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Ppp2cb	IDA		Rat	PMID:16519540|RGD:1582610
Molecular Function	GO:0044325	transmembrane transporter binding	Ppp2cb	IPI	RGD:2245	Rat	PMID:16519540|RGD:1582610
Cellular Component	GO:0005737	cytoplasm	Ppp2cb	IDA		Mouse	PMID:10781942
Cellular Component	GO:0000159	protein phosphatase type 2A complex	Ppp2cb	IDA		Mouse	PMID:16717086
Biological Process	GO:0008637	apoptotic mitochondrial changes	Ppp2cb	IMP		Mouse	PMID:16717086
Biological Process	GO:0010629	negative regulation of gene expression	PPP2CB	IGI	UniProtKB:P01375	Human	PMID:28159925
Biological Process	GO:0010629	negative regulation of gene expression	PPP2CB	IMP		Human	PMID:28159925
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PPP2CB	IGI	UniProtKB:Q04206	Human	PMID:28159925
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Ppp2cb	IDA		Rat	PMID:11884620|RGD:729591
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	PPP2CB	IGI	UniProtKB:P01375	Human	PMID:28159925
Biological Process	GO:1904528	positive regulation of microtubule binding	Ppp2cb	IMP		Rat	PMID:10640627|RGD:13464259
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Ppp2cb	IMP		Mouse	PMID:16717086
Biological Process	GO:0006470	protein dephosphorylation	Ppp2cb	IDA		Rat	PMID:16519540|RGD:1582610
Biological Process	GO:0010468	regulation of gene expression	Ppp2cb	IMP		Mouse	PMID:16717086
Biological Process	GO:0046677	response to antibiotic	Ppp2cb	IMP		Mouse	PMID:16717086
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Ppp2cb	IMP		Mouse	PMID:16717086
Biological Process	GO:0042542	response to hydrogen peroxide	Ppp2cb	IMP		Mouse	PMID:16717086
Biological Process	GO:0010288	response to lead ion	Ppp2cb	IDA		Rat	PMID:22387731|RGD:13506262

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern