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Ppp2cb
Gene Detail
Symbol

Name
ID
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
MGI:1321161
Synonyms
D8Ertd766e, PP2Ac
Feature Type
protein coding gene
Genetic Map
Chromosome 8
20.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:33599621-33619794 bp, + strand
From Ensembl annotation of GRCm38

  20174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37889  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp2cb

Human
homologs
Human Homolog PPP2CB, protein phosphatase 2, catalytic subunit, beta isozyme
NCBI Gene ID 5516
neXtProt AC  NX_P62714
Human Synonyms  PP2Abeta, PP2CB
Human Chr (Location)  8p12; chr8:30785610-30812836 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile.
 
Interactions
Ppp2cb interacts with 188 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (79)    Tissues (47)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
Western blot 4
RT-PCR 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000009630 (Evidence)
Entrez Gene19053 (Evidence)
NIA Mouse Gene IndexU141747
EC3.1.3.16
Consensus CDS ProjectCCDS22233.1
International Mouse Knockout Project StatusPpp2cb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009630 Ensembl Gene Model | MGI Sequence Detail 20174 C57BL/6J ±  kb
transcript ENSMUST00000009774 Ensembl | MGI Sequence Detail 1826 Not Applicable 
polypeptide ENSMUSP00000009774 Ensembl | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000003210 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
References
(Earliest) J:37188 Kato S, et al., Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. FEBS Lett. 1996 Nov 4;396(2-3):293-7
(Latest) J:184036 Gu P, et al., Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012 May;50(5):429-36
All references(52)
Other
accession IDs
MGI:1289237, MGI:2142462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory