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Ppp2cb Gene Detail
Summary
  • Symbol
    Ppp2cb
  • Name
    protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • Synonyms
    D8Ertd766e, PP2Ac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321161
    NCBI Gene: 19053
  • Gene Overview
    MyGene.info: PPP2CB
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:33599625-33619441 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321161
protein coding gene Chr8:33599621-33619804 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033524
protein coding gene Chr8:32056973-32076823 (+)
A/J MGP_AJ_G0033504
protein coding gene Chr8:30828191-30848009 (+)
AKR/J MGP_AKRJ_G0033428
protein coding gene Chr8:31790292-31811015 (+)
BALB/cJ MGP_BALBcJ_G0033500
protein coding gene Chr8:30950164-30970382 (+)
C3H/HeJ MGP_C3HHeJ_G0033212
protein coding gene Chr8:32120047-32140009 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034016
protein coding gene Chr8:33290206-33310344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030965
protein coding gene Chr8:27633700-27654417 (+)
CAST/EiJ MGP_CASTEiJ_G0032539
protein coding gene Chr8:31542602-31564285 (+)
CBA/J MGP_CBAJ_G0033190
protein coding gene Chr8:34602247-34622216 (+)
DBA/2J MGP_DBA2J_G0033343
protein coding gene Chr8:30811707-30831748 (+)
FVB/NJ MGP_FVBNJ_G0033288
protein coding gene Chr8:30471606-30491983 (+)
LP/J MGP_LPJ_G0033433
protein coding gene Chr8:32011733-32031792 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033330
protein coding gene Chr8:34129414-34151662 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034035
protein coding gene Chr8:31872199-31894786 (+)
PWK/PhJ MGP_PWKPhJ_G0032251
protein coding gene Chr8:30325832-30346253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032082
protein coding gene Chr8:31153120-31175900 (+)
WSB/EiJ MGP_WSBEiJ_G0032655
protein coding gene Chr8:32015172-32036117 (+)



Homology
more
  • Human Ortholog
    PPP2CB, protein phosphatase 2 catalytic subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP2CB, protein phosphatase 2 catalytic subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2Abeta, PP2CB
  • Links
    NCBI Gene ID: 5516
    neXtProt AC: NX_P62714
    UniProt: P62714

  • Chr Location
    8p12; chr8:30785610-30812836 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009630 Ensembl Gene Model | MGI Sequence Detail 19817 C57BL/6J ±  kb
transcript ENSMUST00000009774 Ensembl | MGI Sequence Detail 1469 Not Applicable  
polypeptide ENSMUSP00000009774 Ensembl | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003210 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 17
    cDNA 14
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGI:1289237, MGI:2142462
References
more
  • Summaries
    All 63
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:57652 Becker W, et al., Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem. 1994 Sep 9;269(36):22586-92
  • Latest
    J:264469 Lee JA, et al., Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis. J Biol Chem. 2018 Jun 22;293(25):9636-9650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory