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Ppp2cb Gene Detail
Summary
  • Symbol
    Ppp2cb
  • Name
    protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • Synonyms
    D8Ertd766e, PP2Ac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321161
    NCBI Gene: 19053
  • Gene Overview
    MyGene.info: PPP2CB
Location & Maps
more
  • Sequence Map
    Chr8:33599625-33619441 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19817 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.63 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PPP2CB, protein phosphatase 2 catalytic subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP2CB, protein phosphatase 2 catalytic subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2Abeta, PP2CB
  • Links
    NCBI Gene ID: 5516
    neXtProt AC: NX_P62714

  • Chr Location
    8p12; chr8:30785610-30812836 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
  • All Mutations and Alleles
    21
  • Gene trapped
    16
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060960 VEGA Gene Model | MGI Sequence Detail 19817 C57BL/6J ±  kb
transcript OTTMUST00000148972 VEGA | MGI Sequence Detail 1469 Not Applicable  
polypeptide OTTMUSP00000077364 VEGA | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    177 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003210 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 16
    cDNA 13
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGI:1289237, MGI:2142462
References
more
  • Summaries
    All 55
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:37188 Kato S, et al., Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. FEBS Lett. 1996 Nov 4;396(2-3):293-7
  • Latest
    J:228307 Zhou T, et al., Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory