Ppp2cb
Gene Detail

Symbol Name ID

Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform MGI:1321161

Synonyms

D8Ertd766e, PP2Ac

Feature Type

protein coding gene

Genetic Map

Chromosome 8

20.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:33599621-33619794 bp, + strand From Ensembl annotation of GRCm38   20174 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37889  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp2cb

Human homologs

Human Homolog		PPP2CB, protein phosphatase 2, catalytic subunit, beta isozyme
NCBI Gene ID		5516
neXtProt AC		NX_P62714
Human Synonyms		PP2Abeta, PP2CB
Human Chr (Location)		8p12; chr8:30643126-30670352 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(16)
 

Mice homozygous for a knock-out allele are viable and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	negative regulation of apoptotic process, negative regulation of Ras protein signal transduction, ...
Component	chromosome, chromosome, centromeric region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (79)    Tissues (47)    Images (15)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	67
Western blot	4
RT-PCR	8

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000009630 (Evidence)
Entrez Gene	19053 (Evidence)
NIA Mouse Gene Index	U141747
EC	3.1.3.16
Consensus CDS Project	CCDS22233.1
International Mouse Knockout Project Status	Ppp2cb

Sequences

Length	Strain/Species
genomic	ENSMUSG00000009630	Ensembl Gene Model | MGI Sequence Detail	20174	C57BL/6J
transcript	ENSMUST00000009774	Ensembl | MGI Sequence Detail	1826	Not Applicable
polypeptide	ENSMUSP00000009774	Ensembl | MGI Sequence Detail	309	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000003210	serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

References

(Earliest) J:37188 Kato S, et al., Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. FEBS Lett. 1996 Nov 4;396(2-3):293-7
(Latest) J:184036 Gu P, et al., Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012 May;50(5):429-36
All references(51)

Other accession IDs

MGI:1289237, MGI:2142462