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Gene Ontology Browser
Term Detail
GO term:apoptotic mitochondrial changes
GO id:GO:0008637
Definition:The morphological and physiological alterations undergone by mitochondria during apoptosis.
CommentsThis term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular component organization or biogenesis
                        is-acellular component organization
                                is-aorganelle organization
                                        is-amitochondrion organization
                                                is-aapoptotic mitochondrial changes [GO:0008637] (98 genes, 149 annotations)
                                                        is-amitochondrial fragmentation involved in apoptotic process
                                                        is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        is-arelease of cytochrome c from mitochondria +
                                                        is-arelease of matrix enzymes from mitochondria
                                                is-amitochondrial fission +
                                                is-amitochondrial fusion +
                                                is-amitochondrial genome maintenance +
                                                is-amitochondrial membrane organization +
                                                part-ofmitochondrial protein catabolic process
                                                part-ofmitochondrial proton-transporting ATP synthase complex assembly
                                                part-ofmitochondrial respiratory chain complex assembly +
                                                is-amitochondrial respiratory chain supercomplex assembly
                                                is-amitochondrial RNA processing +
                                                is-amitochondrial translation +
                                                is-amitochondrion distribution +
                                                is-amitochondrion morphogenesis
                                                negatively-regulatesnegative regulation of mitochondrion organization +
                                                positively-regulatespositive regulation of mitochondrion organization +
                                                part-ofprotein targeting to mitochondrion +
                                                regulatesregulation of mitochondrion organization +
                                                is-asperm mitochondrion organization
                                                is-atranscription from mitochondrial promoter +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-aorganelle organization
                                is-amitochondrion organization
                                        is-aapoptotic mitochondrial changes [GO:0008637] (98 genes, 149 annotations)
                                                is-amitochondrial fragmentation involved in apoptotic process
                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                is-arelease of cytochrome c from mitochondria +
                                                is-arelease of matrix enzymes from mitochondria
                                        is-amitochondrial fission +
                                        is-amitochondrial fusion +
                                        is-amitochondrial genome maintenance +
                                        is-amitochondrial membrane organization +
                                        part-ofmitochondrial protein catabolic process
                                        part-ofmitochondrial proton-transporting ATP synthase complex assembly
                                        part-ofmitochondrial respiratory chain complex assembly +
                                        is-amitochondrial respiratory chain supercomplex assembly
                                        is-amitochondrial RNA processing +
                                        is-amitochondrial translation +
                                        is-amitochondrion distribution +
                                        is-amitochondrion morphogenesis
                                        negatively-regulatesnegative regulation of mitochondrion organization +
                                        positively-regulatespositive regulation of mitochondrion organization +
                                        part-ofprotein targeting to mitochondrion +
                                        regulatesregulation of mitochondrion organization +
                                        is-asperm mitochondrion organization
                                        is-atranscription from mitochondrial promoter +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes [GO:0008637] (98 genes, 149 annotations)
                                                                is-amitochondrial fragmentation involved in apoptotic process
                                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                                is-arelease of cytochrome c from mitochondria +
                                                                is-arelease of matrix enzymes from mitochondria
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes [GO:0008637] (98 genes, 149 annotations)
                                                                is-amitochondrial fragmentation involved in apoptotic process
                                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                                is-arelease of cytochrome c from mitochondria +
                                                                is-arelease of matrix enzymes from mitochondria
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes [GO:0008637] (98 genes, 149 annotations)
                                                                is-amitochondrial fragmentation involved in apoptotic process
                                                                is-aregulation of mitochondrial membrane permeability involved in apoptotic process +
                                                                is-arelease of cytochrome c from mitochondria +
                                                                is-arelease of matrix enzymes from mitochondria
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory