Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLVAP
  • Mouse genes Plvap
  • Rat genes Plvap
  • Zfish genes plvapa,plvapb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plvap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Plvap	IPI	RGD:619971	Rat	PMID:10366592|RGD:633737
Molecular Function	GO:0005515	protein binding	PLVAP	IPI	UniProtKB:P08670	Human	PMID:19420356
Molecular Function	GO:0005515	protein binding	PLVAP	IPI	UniProtKB:A0A1U9X8X8	Human	PMID:32296183
Cellular Component	GO:0005901	caveola	PLVAP	IDA		Human	PMID:19420356
Cellular Component	GO:0005901	caveola	PLVAP	IDA		Human	PMID:15155804
Cellular Component	GO:0005901	caveola	Plvap	IDA		Rat	PMID:10366592|RGD:633737
Cellular Component	GO:0009986	cell surface	PLVAP	IDA		Human	PMID:15155804
Cellular Component	GO:0009986	cell surface	PLVAP	IDA		Human	PMID:19420356
Cellular Component	GO:0070062	extracellular exosome	PLVAP	HDA		Human	PMID:18570454
Cellular Component	GO:0016020	membrane	Plvap	IDA		Rat	PMID:10366592|RGD:633737
Biological Process	GO:0032502	developmental process	Plvap	IMP		Mouse	MGI:MGI:5529104|PMID:22782339
Biological Process	GO:0000165	MAPK cascade	PLVAP	IDA		Human	PMID:15155804
Biological Process	GO:0007219	Notch signaling pathway	plvapb	IGI	ZFIN:ZDB-GENO-980202-1107	Zfish	PMID:16999953
Biological Process	GO:0002693	positive regulation of cellular extravasation	PLVAP	IMP		Human	PMID:19420356
Biological Process	GO:0002693	positive regulation of cellular extravasation	Plvap	IMP		Mouse	MGI:MGI:3851669|PMID:19420356
Biological Process	GO:0043114	regulation of vascular permeability	plvapb	IMP	ZFIN:ZDB-GENO-200619-1	Zfish	PMID:31740533
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	PLVAP	IDA		Human	PMID:19420356

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern