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Plvap Gene Detail
Summary
  • Symbol
    Plvap
  • Name
    plasmalemma vesicle associated protein
  • Synonyms
    MECA32, PV-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890497
    NCBI Gene: 84094
  • Gene Overview
    MyGene.info: PLVAP
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71497765-71511752 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890497
protein coding gene Chr8:71497753-71511804 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033750
protein coding gene Chr8:71896726-71915897 (-)
A/J MGP_AJ_G0033733
protein coding gene Chr8:68968863-68982545 (-)
AKR/J MGP_AKRJ_G0033658
protein coding gene Chr8:71003469-71020984 (-)
BALB/cJ MGP_BALBcJ_G0033729
protein coding gene Chr8:69139677-69154732 (-)
C3H/HeJ MGP_C3HHeJ_G0033439
protein coding gene Chr8:71580667-71595860 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034247
protein coding gene Chr8:74636614-74649589 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031189
protein coding gene Chr8:63609094-63622861 (-)
CAST/EiJ MGP_CASTEiJ_G0032764
protein coding gene Chr8:71046097-71061116 (-)
CBA/J MGP_CBAJ_G0033417
protein coding gene Chr8:77279636-77296278 (-)
DBA/2J MGP_DBA2J_G0033571
protein coding gene Chr8:68700567-68714470 (-)
FVB/NJ MGP_FVBNJ_G0033513
protein coding gene Chr8:67779704-67795782 (-)
LP/J MGP_LPJ_G0033658
protein coding gene Chr8:71873166-71888396 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033560
protein coding gene Chr8:79833944-79848225 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034264
protein coding gene Chr8:71065954-71080578 (-)
PWK/PhJ MGP_PWKPhJ_G0032471
protein coding gene Chr8:67975862-67989835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032308
protein coding gene Chr8:70013588-70027118 (-)
WSB/EiJ MGP_WSBEiJ_G0032879
protein coding gene Chr8:71414560-71430999 (-)



Homology
more
  • Human Ortholog
    PLVAP, plasmalemma vesicle associated protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PLVAP, plasmalemma vesicle associated protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FELS, gp68, PV1, PV-1
  • Links
    NCBI Gene ID: 83483
    neXtProt AC: NX_Q9BX97
    UniProt: Q9BX97

  • Chr Location
    19p13.11; chr19:17351448-17377349 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 3 alleles in 9 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display background sensitive lethality, absence of diaphragms from fenestrated endothelia, increased vascular permeability, hypoproteinemia, ascites, edema, xanthoma and increased plasma triglyceride levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034845 Ensembl Gene Model | MGI Sequence Detail 13988 C57BL/6J ±  kb
    transcript ENSMUST00000048452 Ensembl | MGI Sequence Detail 1987 Not Applicable  
    polypeptide ENSMUSP00000035404 Ensembl | MGI Sequence Detail 438 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR009538 Plasmalemma vesicle-associated protein
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 49
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 33
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:24500 Hallmann R, et al., Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev Dyn. 1995 Apr;202(4):325-32
    • Latest
      J:253618 Bonney S, et al., Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. eNeuro. 2017 May-Jun;4(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory