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Plvap
Gene Detail
 Symbol
Name
ID
Plvap
plasmalemma vesicle associated protein
MGI:1890497
Synonyms MECA32, PV-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:71497754-71511769 bp, - strand
From Ensembl annotation of GRCm38

  14016 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10578  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Plvap

Human
homologs
Human Homolog PLVAP, plasmalemma vesicle associated protein
NCBI Gene ID 83483
neXtProt AC  NX_Q9BX97
Human Synonyms  FELS, gp68, PV1, PV-1
Human Chr (Location)  19p13.2; chr19:17351455-17377328 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(48) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display background sensitive lethality, absence of diaphragms from fenestrated endothelia, increased vascular permeability, hypoproteinemia, ascites, edema, xanthoma and increased plasma triglyceride levels.
 
Interactions
Plvap interacts with 89 markers (Mir26a-2, Mir26b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process MAPK cascade, positive regulation of cellular extravasation, ...
Component caveola, cell surface, ...
Function protein homodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (13)    Tissues (13)    Images (1)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 1
Northern blot 12
cDNA source data(50)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000034845 (Evidence)
Entrez Gene84094 (Evidence)
UniGene260768
DFCITC1580279
DoTSDT.530722, DT.94308638, DT.97411531
Consensus CDS ProjectCCDS22396.1
International Mouse Knockout Project StatusPlvap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034845 Ensembl Gene Model | MGI Sequence Detail 14016 C57BL/6J ±  kb
transcript ENSMUST00000048452 Ensembl | MGI Sequence Detail 2015 Not Applicable 
polypeptide ENSMUSP00000035404 Ensembl | MGI Sequence Detail 438 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009538 PV-1
Protein Ontology PR:000012890 plasmalemma vesicle-associated protein
References (Earliest) J:24500 Hallmann R, et al., Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev Dyn. 1995 Apr;202(4):325-32
(Latest) J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory