Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIP4K2A
  • Mouse genes Pip4k2a
  • Rat genes Pip4k2a
  • Zfish genes pip4k2aa,pip4k2ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pip4k2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP4K2A	IDA		Human	PMID:26774281
Molecular Function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	pip4k2aa	IMP	ZFIN:ZDB-MRPHLNO-130801-3	Zfish	PMID:23542014
Molecular Function	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	PIP4K2A	IDA		Human	PMID:30718367
Molecular Function	GO:0005515	protein binding	PIP4K2A	IPI	UniProtKB:Q99687-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pip4k2a	IPI	UniProtKB:Q13496|UniProtKB:Q96A65	Mouse	MGI:MGI:5925501|PMID:26760201
Molecular Function	GO:0042803	protein homodimerization activity	PIP4K2A	IDA		Human	PMID:32130941
Cellular Component	GO:0005776	autophagosome	PIP4K2A	IMP		Human	PMID:25578879
Cellular Component	GO:0005829	cytosol	PIP4K2A	IDA		Human	PMID:30718367
Cellular Component	GO:0005764	lysosome	Pip4k2a	IDA		Mouse	MGI:MGI:6159303|PMID:29727621
Cellular Component	GO:0005886	plasma membrane	PIP4K2A	IDA		Human	PMID:30718367
Biological Process	GO:1902635	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	PIP4K2A	IDA		Human	PMID:26774281
Biological Process	GO:0061909	autophagosome-lysosome fusion	Pip4k2a	IMP		Mouse	MGI:MGI:6159303|PMID:29727621
Biological Process	GO:0035855	megakaryocyte development	Pip4k2a	IMP		Mouse	MGI:MGI:3776733|PMID:16434494
Biological Process	GO:0090217	negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP4K2A	IMP		Human	PMID:31091439
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	PIP4K2A	IMP		Human	PMID:31091439
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	pip4k2aa	IMP	ZFIN:ZDB-MRPHLNO-130801-3	Zfish	PMID:23542014|ZFIN:ZDB-PUB-130412-2
Biological Process	GO:2000786	positive regulation of autophagosome assembly	PIP4K2A	IMP		Human	PMID:25578879
Biological Process	GO:0010506	regulation of autophagy	PIP4K2A	IMP		Human	PMID:25578879
Biological Process	GO:0010506	regulation of autophagy	Pip4k2a	IMP		Mouse	MGI:MGI:6159303|PMID:29727621
Biological Process	GO:0048634	regulation of muscle organ development	pip4k2aa	IMP	ZFIN:ZDB-MRPHLNO-130801-3	Zfish	PMID:25866244
Biological Process	GO:0090119	vesicle-mediated cholesterol transport	PIP4K2A	IMP		Human	PMID:29353240

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern