Pip4k2a
Gene Detail

Symbol Name ID

Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha MGI:1298206

Synonyms

Pip5k2a

Feature Type

protein coding gene

Genetic Map

Chromosome 2

12.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:18842255-18998126 bp, - strand From VEGA annotation of GRCm38   155872 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37995  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip4k2a

Human homologs

Human Homolog		PIP4K2A, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
NCBI Gene ID		5305
neXtProt AC		NX_P48426
Human Synonyms		PI5P4KA, PIP5K2A, PIP5KIIA, PIP5KII-alpha, PIPK
Human Chr (Location)		10p12.2; chr10:22823766-23003503 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	megakaryocyte development, phosphatidylinositol metabolic process, ...
Component	cytoplasm, membrane, ...
Function	1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (434)    Tissues (154)    Images (54)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	433
Northern blot	1

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000011477 (Evidence)
Ensembl Gene Model	ENSMUSG00000026737 (Evidence)
Entrez Gene	18718 (Evidence)
DFCI	TC1577775
DoTS	DT.101349725, DT.532526
EC	2.7.1.149
Consensus CDS Project	CCDS15712.1
International Mouse Knockout Project Status	Pip4k2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011477	VEGA Gene Model | MGI Sequence Detail	155872	C57BL/6J
transcript	OTTMUST00000026831	VEGA | MGI Sequence Detail	3477	Not Applicable
polypeptide	OTTMUSP00000012251	VEGA | MGI Sequence Detail	405	Not Applicable

All sequences(33) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(926 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023610	Phosphatidylinositol-4-phosphate 5-kinase
InterPro	IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro	IPR016034	Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro	IPR027483	Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro	IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology	PR:000012741	phosphatidylinositol-5-phosphate 4-kinase type-2 alpha

References

(Earliest) J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
(Latest) J:195197 Vlangos CN, et al., Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression. PLoS Genet. 2013 Feb;9(2):e1003205
All references(36)

Other accession IDs

MGI:2139412