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Pip4k2a
Gene Detail
Symbol

Name
ID
Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
MGI:1298206
Synonyms
Pip5k2a
Feature Type
protein coding gene
Genetic Map
Chromosome 2
12.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:18842255-18998126 bp, - strand
From VEGA annotation of GRCm38

  155872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37995  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIP4K2A
Protein SuperFamily: phosphatidylinositol-4-phosphate 5-kinase type II alpha
Gene Tree: Pip4k2a

Human
homologs
PIP4K2A, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5305
neXtProt AC: NX_P48426

Human Synonyms: PI5P4KA, PIP5K2A, PIP5KIIA, PIP5KII-alpha, PIPK

Human Chr (Location): 10p12.2; chr10:22534837-22714574 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pip4k2a interacts with 326 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process megakaryocyte development, phosphatidylinositol metabolic process, ...
Component cytoplasm, membrane, ...
Function 1-phosphatidylinositol-5-phosphate 4-kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (465)    Tissues (184)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 461
Northern blot 1
RT-PCR 3
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pip4k2a ; ZFIN pip4k2aa, pip4k2ab    NEW 
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000011477 (Evidence)
Ensembl Gene Model ENSMUSG00000026737 (Evidence)
Entrez Gene 18718 (Evidence)
DFCI TC1577775
DoTS DT.532526, DT.101349725
EC 2.7.1.149
Consensus CDS Project CCDS15712.1
International Mouse Phenotyping Consortium Status Pip4k2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011477 VEGA Gene Model | MGI Sequence Detail 155872 C57BL/6J ±  kb
transcript OTTMUST00000026831 VEGA | MGI Sequence Detail 3477 Not Applicable 
polypeptide OTTMUSP00000012251 VEGA | MGI Sequence Detail 405 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(1079 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology PR:000012741 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
References
(Earliest) J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
(Latest) J:205288 Emerling BM, et al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7;155(4):844-57
All references(39)
Other
accession IDs
MGI:2139412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory