Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PIM2
  • Mouse genes Pim2
  • Rat genes
  • Zfish genes pim2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pim2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PIM2	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	PIM2	IPI	UniProtKB:O75541	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PIM2	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Pim2	IPI	UniProtKB:P01108	Mouse	MGI:MGI:5294288|PMID:18438430
Molecular Function	GO:0005515	protein binding	Pim2	IPI	PR:O35716	Mouse	PMID:11854514
Molecular Function	GO:0004672	protein kinase activity	Pim2	IDA		Mouse	PMID:11854514
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PIM2	IDA		Human	PMID:18593906
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pim2	IDA		Mouse	MGI:MGI:5294288|PMID:18438430
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Pim2	IDA		Mouse	PMID:12869584
Biological Process	GO:0008637	apoptotic mitochondrial changes	Pim2	IDA		Mouse	PMID:12869584
Biological Process	GO:0006915	apoptotic process	Pim2	IMP		Mouse	PMID:17476689
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	PIM2	IDA		Human	PMID:20307683
Biological Process	GO:0016236	macroautophagy	Pim2	IMP		Mouse	PMID:17476689
Biological Process	GO:0043066	negative regulation of apoptotic process	PIM2	IDA		Human	PMID:18675992
Biological Process	GO:0043066	negative regulation of apoptotic process	Pim2	IMP		Mouse	PMID:17476689
Biological Process	GO:0043066	negative regulation of apoptotic process	Pim2	IDA		Mouse	PMID:12869584
Biological Process	GO:0008285	negative regulation of cell population proliferation	PIM2	IDA		Human	PMID:20307683
Biological Process	GO:0032091	negative regulation of protein binding	Pim2	IMP		Mouse	PMID:17476689
Biological Process	GO:0010508	positive regulation of autophagy	Pim2	IMP		Mouse	MGI:MGI:4361989|PMID:17476689
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Pim2	IMP		Mouse	MGI:MGI:5294288|PMID:18438430
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Pim2	IDA		Mouse	MGI:MGI:3510500|PMID:15548703
Biological Process	GO:0016239	positive regulation of macroautophagy	Pim2	IMP		Mouse	PMID:17476689
Biological Process	GO:0006468	protein phosphorylation	PIM2	IDA		Human	PMID:18593906
Biological Process	GO:0006468	protein phosphorylation	Pim2	IDA		Mouse	MGI:MGI:3510500|PMID:15548703
Biological Process	GO:0050821	protein stabilization	PIM2	IMP		Human	PMID:20307683
Biological Process	GO:0050821	protein stabilization	Pim2	IDA		Mouse	MGI:MGI:5294288|PMID:18438430
Biological Process	GO:0009615	response to virus	PIM2	IEP		Human	PMID:16548883

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern