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Pim2 Gene Detail
Summary
  • Symbol
    Pim2
  • Name
    proviral integration site 2
  • Synonyms
    DXCch3, Pim-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97587
    NCBI Gene: 18715
  • Gene Overview
    MyGene.info: PIM2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7878306-7883432 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97587
protein coding gene ChrX:7878262-7883432 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035527
protein coding gene ChrX:2499128-2506104 (+)
A/J MGP_AJ_G0035505
protein coding gene ChrX:2461601-2467510 (+)
AKR/J MGP_AKRJ_G0035437
protein coding gene ChrX:2579016-2583869 (+)
BALB/cJ MGP_BALBcJ_G0035501
protein coding gene ChrX:2490239-2495410 (+)
C3H/HeJ MGP_C3HHeJ_G0035209
protein coding gene ChrX:2551698-2556867 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036025
protein coding gene ChrX:2589317-2594486 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032901
protein coding gene ChrX:2023031-2028128 (+)
CAST/EiJ MGP_CASTEiJ_G0034510
protein coding gene ChrX:2439372-2445982 (+)
CBA/J MGP_CBAJ_G0035179
protein coding gene ChrX:2707408-2712577 (+)
DBA/2J MGP_DBA2J_G0035336
protein coding gene ChrX:2486024-2491194 (+)
FVB/NJ MGP_FVBNJ_G0035283
protein coding gene ChrX:2445241-2450455 (+)
LP/J MGP_LPJ_G0035414
protein coding gene ChrX:2521035-2526297 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035323
protein coding gene ChrX:2679117-2684285 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036043
protein coding gene ChrX:2487509-2493326 (+)
PWK/PhJ MGP_PWKPhJ_G0034211
protein coding gene ChrX:2414908-2421191 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034049
protein coding gene ChrX:2470385-2474878 (+)
WSB/EiJ MGP_WSBEiJ_G0034633
protein coding gene ChrX:2497345-2502509 (+)



Homology
more
  • Human Ortholog
    PIM2, Pim-2 proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PIM2, Pim-2 proto-oncogene, serine/threonine kinase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 11040
    neXtProt AC: NX_Q9P1W9
    UniProt: Q9P1W9

  • Chr Location
    Xp11.23; chrX:48913182-48919136 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18715 NCBI Gene Model | MGI Sequence Detail 5127 C57BL/6J ±  kb
transcript NM_138606 RefSeq | MGI Sequence Detail 2054 Not Specified  
polypeptide Q62070 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR017348 Serine/threonine-protein kinase pim-1/2/3
Molecular
Reagents
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  • All nucleic 44
    Genomic 5
    cDNA 36
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13309, MGD-MRK-13313, MGI:1891439
References
more
  • Summaries
    All 58
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 21
  • Earliest
    J:9795 Breuer ML, et al., Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J. 1989 Mar;8(3):743-8
  • Latest
    J:265434 Daenthanasanmak A, et al., PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018 Jul 2;128(7):2787-2801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory