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Pim2
Gene Detail
Symbol

Name
ID
Pim2
proviral integration site 2
MGI:97587
Synonyms
DXCch3, Pim-2
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:7878262-7883432 bp, + strand
From VEGA annotation of GRCm38

  5171 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17098  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: PIM2
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Pim2

Human
homologs
PIM2, Pim-2 proto-oncogene, serine/threonine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11040
neXtProt AC: NX_Q9P1W9

Human Chr (Location): Xp11.23; chrX:48913182-48919136 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes.
 
Interactions
Pim2 interacts with 164 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process apoptotic mitochondrial changes, apoptotic process, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (12)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 26
RT-PCR 3
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN pim2    NEW 
Molecular
reagents
All nucleic(43) Genomic(5) cDNA(35) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018000 (Evidence)
Ensembl Gene Model ENSMUSG00000031155 (Evidence)
Entrez Gene 18715 (Evidence)
UniGene 347478
DFCI TC1578809, TC1607838, TC1761652
DoTS DT.491938, DT.91362215
NIA Mouse Gene Index U019672
EC 2.7.11.1
Consensus CDS Project CCDS29976.1
International Mouse Phenotyping Consortium Status Pim2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018000 VEGA Gene Model | MGI Sequence Detail 5171 C57BL/6J ±  kb
transcript OTTMUST00000043463 VEGA | MGI Sequence Detail 2045 Not Applicable 
polypeptide OTTMUSP00000019528 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR017348 Proto-oncogene serine/threonine-protein kinase Pim-1
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012733 serine/threonine-protein kinase Pim-2
References
(Earliest) J:9795 Breuer ML, et al., Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J. 1989 Mar;8(3):743-8
(Latest) J:196871 An N, et al., Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells. Stem Cells. 2013 Jun;31(6):1202-12
All references(56)
Other
accession IDs
MGD-MRK-13309, MGD-MRK-13313, MGI:1891439

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory