Pim2
Gene Detail

Symbol Name ID

Pim2 proviral integration site 2 MGI:97587

Synonyms

DXCch3, Pim-2

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:7878262-7883432 bp, + strand From VEGA annotation of GRCm38   5171 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17098  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Pim2

Human homologs

Human Homolog		PIM2, pim-2 oncogene
NCBI Gene ID		11040
neXtProt AC		NX_Q9P1W9
Human Chr (Location)		Xp11.23; chrX:48770459-48776413 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	apoptotic mitochondrial changes, apoptotic process, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (12)    Images (2)
Theiler Stages: 24, 28

Assay Type	Results
Northern blot	26
RT-PCR	3

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(5) cDNA(34) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000018000 (Evidence)
Ensembl Gene Model	ENSMUSG00000031155 (Evidence)
Entrez Gene	18715 (Evidence)
UniGene	347478
DFCI	TC1578809, TC1607838, TC1761652
DoTS	DT.491938, DT.91362215
NIA Mouse Gene Index	U019672
EC	2.7.11.1
Consensus CDS Project	CCDS29976.1
International Mouse Knockout Project Status	Pim2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018000	VEGA Gene Model | MGI Sequence Detail	5171	C57BL/6J
transcript	OTTMUST00000043463	VEGA | MGI Sequence Detail	2045	Not Applicable
polypeptide	OTTMUSP00000019528	VEGA | MGI Sequence Detail	370	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000012733	serine/threonine-protein kinase Pim-2

References

(Earliest) J:9795 Breuer ML, et al., Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J. 1989 Mar;8(3):743-8
(Latest) J:190962 Narlik-Grassow M, et al., The essential role of PIM kinases in sarcoma growth and bone invasion. Carcinogenesis. 2012 Aug;33(8):1479-86
All references(56)

Other accession IDs

MGD-MRK-13309, MGD-MRK-13313, MGI:1891439