Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PHB2
  • Mouse genes Phb2
  • Rat genes Phb2
  • Zfish genes phb2a,phb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Phb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0033218	amide binding	PHB2	IPI	CHEBI:3374	Human	PMID:19116139
Molecular Function	GO:0042802	identical protein binding	PHB2	IPI	UniProtKB:Q99623	Human	PMID:31522117
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P03372	Human	PMID:10359819
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P35232	Human	PMID:11302691
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:O00165	Human	PMID:17008324
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q99496	Human	PMID:18629613
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P05141	Human	PMID:19116139
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P0C6X7	Human	PMID:19640993
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P03375	Human	PMID:19906925
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P35232	Human	PMID:20959514
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q9H7S9	Human	PMID:21328542
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q9UJZ1	Human	PMID:21746876
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P24592	Human	PMID:24003225
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q9GZQ8	Human	PMID:28017329
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P35232	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:P35232	Human	PMID:31522117
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q9H078	Human	PMID:31522117
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q16828	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PHB2	IPI	UniProtKB:Q9BR81	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Phb2	IPI	UniProtKB:Q13547|UniProtKB:Q9Z2V6	Mouse	MGI:MGI:3688342|PMID:15140878
Molecular Function	GO:0005515	protein binding	Phb2	IPI	UniProtKB:P67778	Mouse	MGI:MGI:6294409|PMID:20959514
Molecular Function	GO:0005515	protein binding	Phb2	IPI	UniProtKB:P19783|UniProtKB:Q9JIA7	Mouse	MGI:MGI:6294409|PMID:20959514
Molecular Function	GO:0005515	protein binding	Phb2	IPI	UniProtKB:P19785	Mouse	MGI:MGI:3687892|PMID:12878603
Molecular Function	GO:0005515	protein binding	Phb2	IPI	UniProtKB:P67778,UniProtKB:Q8JZQ2,UniProtKB:Q9CQV7	Mouse	MGI:MGI:5604945|PMID:24856930
Molecular Function	GO:0005515	protein binding	Phb2	IPI	UniProtKB:P42082,UniProtKB:P67778	Mouse	MGI:MGI:5461234|PMID:23241883
Molecular Function	GO:0005515	protein binding	Phb2	IPI	PR:Q9Z0Z3	Mouse	PMID:17785450
Molecular Function	GO:0046982	protein heterodimerization activity	PHB2	IPI	UniProtKB:P35232	Human	PMID:28017329
Molecular Function	GO:0042803	protein homodimerization activity	PHB2	IDA		Human	PMID:31522117
Molecular Function	GO:0046625	sphingolipid binding	PHB2	IDA		Human	PMID:20959514
Molecular Function	GO:0046625	sphingolipid binding	Phb2	IDA		Mouse	MGI:MGI:6294409|PMID:20959514
Cellular Component	GO:0030424	axon	Phb2	IDA		Rat	PMID:23568660|RGD:12903961
Cellular Component	GO:0071944	cell periphery	PHB2	IDA		Human	PMID:19906925
Cellular Component	GO:0009986	cell surface	PHB2	IDA		Human	PMID:22417827
Cellular Component	GO:0009986	cell surface	PHB2	IDA		Human	PMID:22997079
Cellular Component	GO:0009986	cell surface	Phb2	IDA		Mouse	MGI:MGI:5621261|PMID:22417827
Cellular Component	GO:0005737	cytoplasm	PHB2	IDA		Human	PMID:19116139
Cellular Component	GO:0005737	cytoplasm	PHB2	IDA		Human	PMID:32276428
Cellular Component	GO:0005737	cytoplasm	Phb2	IDA		Rat	PMID:24566151|RGD:12903261
Cellular Component	GO:0098982	GABA-ergic synapse	Phb2	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098982	GABA-ergic synapse	Phb2	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Phb2	EXP		Rat	PMID:17623647|RGD:13702283
Cellular Component	GO:0098978	glutamatergic synapse	Phb2	IDA		Rat	PMID:17623647|RGD:13702283
Cellular Component	GO:0098978	glutamatergic synapse	Phb2	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Phb2	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098800	inner mitochondrial membrane protein complex	Phb2	IDA		Mouse	MGI:MGI:5604945|PMID:24856930
Cellular Component	GO:0005743	mitochondrial inner membrane	PHB2	IDA		Human	PMID:18339324
Cellular Component	GO:0005743	mitochondrial inner membrane	PHB2	IDA		Human	PMID:20959514
Cellular Component	GO:0005743	mitochondrial inner membrane	PHB2	IDA		Human	PMID:28017329
Cellular Component	GO:0005743	mitochondrial inner membrane	Phb2	IDA		Mouse	MGI:MGI:6294409|PMID:20959514
Cellular Component	GO:0005743	mitochondrial inner membrane	Phb2	IDA		Mouse	MGI:MGI:3688068|PMID:11302691
Cellular Component	GO:0005741	mitochondrial outer membrane	PHB2	IDA		Human	PMID:17008324
Cellular Component	GO:0035632	mitochondrial prohibitin complex	PHB2	IPI		Human	PMID:20959514
Cellular Component	GO:0035632	mitochondrial prohibitin complex	PHB2	IDA		Human	PMID:31522117
Cellular Component	GO:0035632	mitochondrial prohibitin complex	Phb2	IPI		Mouse	MGI:MGI:6294409|PMID:20959514
Cellular Component	GO:0005739	mitochondrion	PHB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	PHB2	IDA		Human	PMID:19906925
Cellular Component	GO:0005739	mitochondrion	PHB2	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Phb2	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Phb2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Phb2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Phb2	IDA		Rat	PMID:19116139|RGD:10047336
Cellular Component	GO:0016363	nuclear matrix	PHB2	IDA		Human	PMID:21328542
Cellular Component	GO:0005634	nucleus	PHB2	IDA		Human	PMID:17008324
Cellular Component	GO:0005634	nucleus	PHB2	IDA		Human	PMID:19116139
Cellular Component	GO:0005634	nucleus	PHB2	IDA		Human	PMID:20959514
Cellular Component	GO:0005634	nucleus	PHB2	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Phb2	IDA		Mouse	MGI:MGI:3688342|PMID:15140878
Cellular Component	GO:0005634	nucleus	Phb2	IDA		Mouse	MGI:MGI:6294409|PMID:20959514
Cellular Component	GO:0005634	nucleus	Phb2	IDA		Rat	PMID:24566151|RGD:12903261
Cellular Component	GO:0005886	plasma membrane	PHB2	IDA		Human	PMID:22997079
Cellular Component	GO:0005886	plasma membrane	PHB2	IDA		Human	PMID:24003225
Cellular Component	GO:0014069	postsynaptic density	Phb2	EXP		Rat	PMID:17623647|RGD:13702283
Cellular Component	GO:0014069	postsynaptic density	Phb2	IDA		Rat	PMID:17623647|RGD:13702283
Cellular Component	GO:0048786	presynaptic active zone	Phb2	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0048786	presynaptic active zone	Phb2	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0032991	protein-containing complex	PHB2	IDA		Human	PMID:21328542
Biological Process	GO:0007202	activation of phospholipase C activity	Phb2	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:1990051	activation of protein kinase C activity	Phb2	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0140374	antiviral innate immune response	PHB2	IDA		Human	PMID:31522117
Biological Process	GO:0042113	B cell activation	Phb2	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0023035	CD40 signaling pathway	Phb2	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0016477	cell migration	PHB2	IDA		Human	PMID:24003225
Biological Process	GO:0071456	cellular response to hypoxia	Phb2	IEP		Rat	PMID:25031298|RGD:12903263
Biological Process	GO:0071300	cellular response to retinoic acid	Phb2	IEP		Rat	PMID:25031298|RGD:12903263
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:0060749	mammary gland alveolus development	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:0060744	mammary gland branching involved in thelarche	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:0007005	mitochondrion organization	PHB2	IMP		Human	PMID:17008324
Biological Process	GO:0000423	mitophagy	PHB2	IDA		Human	PMID:28017329
Biological Process	GO:0000423	mitophagy	Phb2	IDA		Mouse	MGI:MGI:6436385|PMID:28017329
Biological Process	GO:0043066	negative regulation of apoptotic process	PHB2	IMP		Human	PMID:17008324
Biological Process	GO:0043066	negative regulation of apoptotic process	Phb2	IMP		Rat	PMID:24566151|RGD:12903261
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	PHB2	IMP		Human	PMID:18629613
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PHB2	IDA		Human	PMID:10359819
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Phb2	IDA		Mouse	MGI:MGI:3688342|PMID:15140878
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Phb2	IGI	MGI:MGI:1351663	Mouse	PMID:17785450
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	PHB2	IMP		Human	PMID:23548868
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	PHB2	IDA		Human	PMID:18629613
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PHB2	IMP		Human	PMID:22417827
Biological Process	GO:0031536	positive regulation of exit from mitosis	PHB2	IMP		Human	PMID:23548868
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Phb2	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Phb2	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0006606	protein import into nucleus	PHB2	IDA		Human	PMID:17008324
Biological Process	GO:0050821	protein stabilization	PHB2	IMP		Human	PMID:17008324
Biological Process	GO:0050821	protein stabilization	PHB2	IDA		Human	PMID:18339324
Biological Process	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	Phb2	IMP	MGI:MGI:3574361	Mouse	PMID:17065319
Biological Process	GO:1900208	regulation of cardiolipin metabolic process	Phb2	IMP		Mouse	MGI:MGI:5604945|PMID:24856930
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	PHB2	IMP		Human	PMID:20959514
Biological Process	GO:1904959	regulation of cytochrome-c oxidase activity	Phb2	IMP		Mouse	MGI:MGI:6294409|PMID:20959514
Biological Process	GO:0009611	response to wounding	Phb2	IEP		Rat	PMID:24566151|RGD:12903261
Biological Process	GO:0039529	RIG-I signaling pathway	PHB2	IDA		Human	PMID:31522117
Biological Process	GO:0007062	sister chromatid cohesion	PHB2	IDA		Human	PMID:23548868

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern