Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDIA4
  • Mouse genes Pdia4
  • Rat genes Pdia4
  • Zfish genes pdia4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdia4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	Pdia4	IPI	PR:O54890	Mouse	PMID:28576878
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:O15232	Human	PMID:16287128
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:Q76353	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:P23284	Human	PMID:22665516
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:P23284:PRO_0000025479	Human	PMID:22665516
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:O15232	Human	PMID:23956175
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:P23284	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:P59990	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:P80188	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDIA4	IPI	UniProtKB:Q9BYQ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Pdia4	IPI	UniProtKB:P24368	Rat	PMID:22665516|RGD:8553430
Molecular Function	GO:0005515	protein binding	Pdia4	IPI	UniProtKB:Q9VVJ7	Rat	PMID:22665516|RGD:8553430
Molecular Function	GO:0005515	protein binding	Pdia4	IPI	UniProtKB:P06882	Rat	PMID:7916014|RGD:8554190
Molecular Function	GO:0003756	protein disulfide isomerase activity	Pdia4	IDA		Mouse	PMID:28576878
Molecular Function	GO:0003756	protein disulfide isomerase activity	Pdia4	IDA		Rat	PMID:22665516|RGD:8553430
Molecular Function	GO:0003756	protein disulfide isomerase activity	Pdia4	IDA		Rat	PMID:8477750|RGD:632673
Molecular Function	GO:0015035	protein-disulfide reductase activity	PDIA4	IDA		Human	PMID:16677074
Molecular Function	GO:0003723	RNA binding	PDIA4	HDA		Human	PMID:22658674
Cellular Component	GO:0009986	cell surface	PDIA4	IDA		Human	PMID:19995400
Cellular Component	GO:0009986	cell surface	Pdia4	IDA		Mouse	PMID:19995400
Cellular Component	GO:0005783	endoplasmic reticulum	Pdia4	IDA		Mouse	PMID:35353806
Cellular Component	GO:0005783	endoplasmic reticulum	Pdia4	IDA		Mouse	PMID:9493907
Cellular Component	GO:0005783	endoplasmic reticulum	Pdia4	IDA		Mouse	PMID:24239381
Cellular Component	GO:0034663	endoplasmic reticulum chaperone complex	Pdia4	IDA		Mouse	MGI:MGI:5613481|PMID:12475965
Cellular Component	GO:0005615	extracellular space	PDIA4	IDA		Human	PMID:19995400
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Pdia4	IDA		Rat	PMID:22665516|RGD:8553430
Biological Process	GO:0072378	blood coagulation, fibrin clot formation	Pdia4	IMP	MGI:MGI:5636896	Mouse	PMID:28576878
Biological Process	GO:0061077	chaperone-mediated protein folding	Pdia4	IDA		Rat	PMID:22665516|RGD:8553430
Biological Process	GO:0070527	platelet aggregation	Pdia4	IMP	MGI:MGI:5636896	Mouse	PMID:28576878
Biological Process	GO:1903334	positive regulation of protein folding	Pdia4	IDA		Rat	PMID:16184766|RGD:9999184

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern