Pdia4 MGI Mouse Gene Detail - MGI:104864 - protein disulfide isomerase associated 4

Symbol

Pdia4
Name

protein disulfide isomerase associated 4
Synonyms

Cai, Erp72, ERp72, U48620

Feature Type

protein coding gene
IDs

MGI:104864
NCBI Gene: 12304
Gene Overview

MyGene.info: PDIA4
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:47796141-47813430 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 22.94 cM
Mapping Data

4 experiments

SNPs within 2kb

117 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104864	protein coding gene	Chr6:47796088-47813512 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030683	protein coding gene	Chr6:46701814-46719102 (-)
A/J	MGP_AJ_G0030655	protein coding gene	Chr6:44549405-44566529 (-)
AKR/J	MGP_AKRJ_G0030580	protein coding gene	Chr6:46090145-46117274 (-)
BALB/cJ	MGP_BALBcJ_G0030665	protein coding gene	Chr6:44901955-44919149 (-)
C3H/HeJ	MGP_C3HHeJ_G0030378	protein coding gene	Chr6:46125270-46142509 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031120	protein coding gene	Chr6:47721284-47738573 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028326	protein coding gene	Chr6:42263852-42282436 (-)
CAST/EiJ	MGP_CASTEiJ_G0029782	protein coding gene	Chr6:45854392-45873352 (-)
CBA/J	MGP_CBAJ_G0030353	protein coding gene	Chr6:49740051-49757249 (-)
DBA/2J	MGP_DBA2J_G0030502	protein coding gene	Chr6:44495365-44512436 (-)
FVB/NJ	MGP_FVBNJ_G0030454	protein coding gene	Chr6:44130479-44147660 (-)
LP/J	MGP_LPJ_G0030586	protein coding gene	Chr6:46601476-46618736 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030488	protein coding gene	Chr6:52618476-52635591 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031149	protein coding gene	Chr6:46011873-46030060 (-)
PWK/PhJ	MGP_PWKPhJ_G0029494	protein coding gene	Chr6:44013430-44030903 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029330	protein coding gene	Chr6:45435688-45452914 (-)
WSB/EiJ	MGP_WSBEiJ_G0029858	protein coding gene	Chr6:46006686-46025499 (-)

Human Ortholog

PDIA4, protein disulfide isomerase family A member 4

Vertebrate Orthologs

9

Human Ortholog

PDIA4, protein disulfide isomerase family A member 4
Orthology source: HomoloGene, HGNC
Synonyms

ERP70, ERp-72, ERP72
Links

HGNC:30167

NCBI Gene ID: 9601

neXtProt AC: NX_P13667

UniProt: P13667
Chr Location

7q36.1; chr7:149003054-149028690 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21020
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PDIA4
Protein SuperFamily

protein disulfide-isomerase A4
Gene Tree

Pdia4

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Phenotype Summary

6 phenotypes from 1 allele in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

7
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in platelets exhibit decreased platelet aggregation and increased bleeding time.

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All GO Annotations

19
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

27
Tissues

5
cDNA Data

156
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdia4

ZFIN pdia4

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Pdia4 interacts with 65 markers (Mir15a, Mir16-1, Mir16-2, ...) View All

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All Sequences

45
RefSeq

4
UniProt

2
CCDS

CCDS20097.1
UniGene

2442

Ensembl

ENSMUSG00000025823 (Evidence)
NCBI Gene

12304

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025823	Ensembl Gene Model \| MGI Sequence Detail	17290	C57BL/6J	± kb
transcript	ENSMUST00000077290	Ensembl \| MGI Sequence Detail	2399	Not Applicable
polypeptide	ENSMUSP00000076521	Ensembl \| MGI Sequence Detail	641	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012499 protein disulfide-isomerase A4

(term hierarchy)
PDB

2DJ1, 2DJ2, 2DJ3
EC

5.3.4.1
InterPro Domains

IPR005788 Disulphide isomerase

IPR041866 Protein disulfide-isomerase A4, TRX-like domain b

IPR005792 Protein disulphide isomerase

IPR017068 Protein disulphide-isomerase A4

IPR017937 Thioredoxin, conserved site

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily

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All nucleic 158

Genomic 2

cDNA 156

Microarray probesets 3

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MGD-MRK-28161, MGI:1201401, MGI:1930896, MGI:2141523

Summaries

All 57

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 11
Earliest

J:22695 Gough NM, et al., An mRNA sharing sequences with a variant granulocyte-macrophage colony stimulating factor cDNA clone. Nucleic Acids Res. 1987 Dec 23;15(24):10584
Latest

J:253982 Norlin S, et al., The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018 Jan 3;145(1)

TSS for Pdia4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60718	Chr6:47813514-47813528 (-)	-91 bp
Tssr60717	Chr6:47813377-47813409 (-)	37 bp
Tssr60716	Chr6:47813338-47813369 (-)	76 bp
Tssr60709	Chr6:47798548-47798573 (-)	14,869 bp
Tssr60708	Chr6:47798430-47798444 (-)	14,993 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14