About   Help   FAQ
Pdia4 Gene Detail
Summary
  • Symbol
    Pdia4
  • Name
    protein disulfide isomerase associated 4
  • Synonyms
    Cai, Erp72, ERp72, U48620
  • Feature Type
    protein coding gene
  • IDs
    MGI:104864
    NCBI Gene: 12304
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:47773075-47790364 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 22.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104864
 protein coding gene Chr6:47773075-47790446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030683
 protein coding gene Chr6:46701814-46719102 (-)
A/J MGP_AJ_G0030655
 protein coding gene Chr6:44549405-44566529 (-)
AKR/J MGP_AKRJ_G0030580
 protein coding gene Chr6:46090145-46117274 (-)
BALB/cJ MGP_BALBcJ_G0030665
 protein coding gene Chr6:44901955-44919149 (-)
C3H/HeJ MGP_C3HHeJ_G0030378
 protein coding gene Chr6:46125270-46142509 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031120
 protein coding gene Chr6:47721284-47738573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028326
 protein coding gene Chr6:42263852-42282436 (-)
CAST/EiJ MGP_CASTEiJ_G0029782
 protein coding gene Chr6:45854392-45873352 (-)
CBA/J MGP_CBAJ_G0030353
 protein coding gene Chr6:49740051-49757249 (-)
DBA/2J MGP_DBA2J_G0030502
 protein coding gene Chr6:44495365-44512436 (-)
FVB/NJ MGP_FVBNJ_G0030454
 protein coding gene Chr6:44130479-44147660 (-)
LP/J MGP_LPJ_G0030586
 protein coding gene Chr6:46601476-46618736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030488
 protein coding gene Chr6:52618476-52635591 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031149
 protein coding gene Chr6:46011873-46030060 (-)
PWK/PhJ MGP_PWKPhJ_G0029494
 protein coding gene Chr6:44013430-44030903 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029330
 protein coding gene Chr6:45435688-45452914 (-)
WSB/EiJ MGP_WSBEiJ_G0029858
 protein coding gene Chr6:46006686-46025499 (-)



Homology
more
  • Human Ortholog
    PDIA4, protein disulfide isomerase family A member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDIA4, protein disulfide isomerase family A member 4
  • Synonyms
    ERP70, ERp-72, ERP72
  • Links
    NCBI Gene ID: 9601
    neXtProt AC: NX_P13667
    UniProt: P13667

  • Chr Location
    7q36.1; chr7:149003054-149028690 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in platelets exhibit decreased platelet aggregation and increased bleeding time.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    5
  • cDNA Data
    156
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025823 Ensembl Gene Model | MGI Sequence Detail 17290 C57BL/6J ±  kb
    transcript ENSMUST00000077290 Ensembl | MGI Sequence Detail 2399 Not Applicable  
    polypeptide ENSMUSP00000076521 Ensembl | MGI Sequence Detail 641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 2
      cDNA 156

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28161, MGI:1201401, MGI:1930896, MGI:2141523
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:22695 Gough NM, et al., An mRNA sharing sequences with a variant granulocyte-macrophage colony stimulating factor cDNA clone. Nucleic Acids Res. 1987 Dec 23;15(24):10584
    • Latest
      J:312492 Chhabra NF, et al., A point mutation in the Pdia6 gene results in loss of pancreatic beta-cell identity causing overt diabetes. Mol Metab. 2021 Sep 4;54:101334
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    08/03/2022
    MGI 6.21     		The Jackson Laboratory