Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pcsk5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PCSK5
- Mouse genes Pcsk5
- Rat genes Pcsk5
- Zfish genes pcsk5a,pcsk5b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pcsk5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	PCSK5	EXP		Human	PMID:16109723
Molecular Function	GO:0004175	endopeptidase activity	PCSK5	EXP		Human	PMID:20581395
Molecular Function	GO:0004175	endopeptidase activity	Pcsk5	IDA		Mouse	MGI:MGI:3807770\|PMID:9242664
Molecular Function	GO:0004175	endopeptidase activity	Pcsk5	IDA		Mouse	MGI:MGI:3795695\|PMID:18519639
Molecular Function	GO:0008233	peptidase activity	PCSK5	IDA		Human	PMID:15606899
Molecular Function	GO:0042277	peptide binding	Pcsk5	IDA		Mouse	MGI:MGI:3799615\|PMID:8940009
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:O75716	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:O76003	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:Q5T5A8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:Q7Z417	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PCSK5	IPI	UniProtKB:Q9BQ66	Human	PMID:25416956
Molecular Function	GO:0004252	serine-type endopeptidase activity	PCSK5	IDA		Human	PMID:8901832
Molecular Function	GO:0004252	serine-type endopeptidase activity	Pcsk5	IDA		Mouse	MGI:MGI:74959\|PMID:8468318
Cellular Component	GO:0005615	extracellular space	Pcsk5	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Pcsk5	IDA		Mouse	MGI:MGI:3799615\|PMID:8940009
Cellular Component	GO:0005794	Golgi apparatus	PCSK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	Pcsk5	IDA		Rat	PMID:10408612\|RGD:11556235
Cellular Component	GO:0005797	Golgi medial cisterna	Pcsk5	IDA		Rat	PMID:10906713\|RGD:11556238
Cellular Component	GO:0043204	perikaryon	Pcsk5	IDA		Rat	PMID:10408612\|RGD:11556235
Cellular Component	GO:0005886	plasma membrane	Pcsk5	IDA		Rat	PMID:10906713\|RGD:11556238
Cellular Component	GO:1990635	proximal dendrite	Pcsk5	IDA		Rat	PMID:10408612\|RGD:11556235
Cellular Component	GO:0005802	trans-Golgi network	Pcsk5	IDA		Rat	PMID:11882580\|RGD:11556216
Biological Process	GO:0048899	anterior lateral line development	pcsk5a	IMP	ZFIN:ZDB-MRPHLNO-101115-3	Zfish	PMID:20882679
Biological Process	GO:0009952	anterior/posterior pattern specification	PCSK5	IMP		Human	PMID:18519639
Biological Process	GO:0009952	anterior/posterior pattern specification	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0003279	cardiac septum development	Pcsk5	IMP		Mouse	PMID:25807483
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Pcsk5	IEP		Rat	PMID:11882580\|RGD:11556216
Biological Process	GO:0060976	coronary vasculature development	Pcsk5	IMP		Mouse	PMID:25807483
Biological Process	GO:0140447	cytokine precursor processing	Pcsk5	IDA		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0007368	determination of left/right symmetry	Pcsk5	IMP		Mouse	PMID:25807483
Biological Process	GO:0007566	embryo implantation	Pcsk5	IMP		Mouse	MGI:MGI:3799557\|PMID:15601911
Biological Process	GO:0048566	embryonic digestive tract development	PCSK5	IMP		Human	PMID:18519639
Biological Process	GO:0048566	embryonic digestive tract development	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0048706	embryonic skeletal system development	PCSK5	IMP		Human	PMID:18519639
Biological Process	GO:0048706	embryonic skeletal system development	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0007507	heart development	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0001822	kidney development	PCSK5	IMP		Human	PMID:18519639
Biological Process	GO:0001822	kidney development	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0035108	limb morphogenesis	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0048884	neuromast development	pcsk5a	IMP	ZFIN:ZDB-MRPHLNO-101115-3	Zfish	PMID:20882679
Biological Process	GO:0048884	neuromast development	pcsk5a	IMP	ZFIN:ZDB-MRPHLNO-101115-4	Zfish	PMID:20882679
Biological Process	GO:0043043	peptide biosynthetic process	PCSK5	IDA		Human	PMID:8901832
Biological Process	GO:0043043	peptide biosynthetic process	Pcsk5	IDA		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0043043	peptide biosynthetic process	Pcsk5	IDA		Mouse	MGI:MGI:74959\|PMID:8468318
Biological Process	GO:0016486	peptide hormone processing	PCSK5	IDA		Human	PMID:8901832
Biological Process	GO:0016486	peptide hormone processing	Pcsk5	IDA		Mouse	MGI:MGI:3807770\|PMID:9242664
Biological Process	GO:0016486	peptide hormone processing	Pcsk5	IDA		Mouse	MGI:MGI:74959\|PMID:8468318
Biological Process	GO:0016486	peptide hormone processing	Pcsk5	IDA		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0033625	positive regulation of integrin activation	Pcsk5	IMP		Rat	PMID:14970114\|RGD:11556214
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	Pcsk5	IMP		Rat	PMID:14970114\|RGD:11556214
Biological Process	GO:1905609	positive regulation of smooth muscle cell-matrix adhesion	Pcsk5	IMP		Rat	PMID:14970114\|RGD:11556214
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	Pcsk5	IMP		Rat	PMID:14970114\|RGD:11556214
Biological Process	GO:0016485	protein processing	PCSK5	IDA		Human	PMID:15606899
Biological Process	GO:0016485	protein processing	PCSK5	IDA		Human	PMID:8901832
Biological Process	GO:0016485	protein processing	Pcsk5	IDA		Mouse	MGI:MGI:74959\|PMID:8468318
Biological Process	GO:0016485	protein processing	Pcsk5	IDA		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0016485	protein processing	Pcsk5	IDA		Mouse	MGI:MGI:3807770\|PMID:9242664
Biological Process	GO:0016485	protein processing	Pcsk5	IDA		Mouse	PMID:21147780
Biological Process	GO:0002001	renin secretion into blood stream	PCSK5	IEP		Human	PMID:8901832
Biological Process	GO:0030323	respiratory tube development	Pcsk5	IMP		Mouse	MGI:MGI:3795695\|PMID:18519639
Biological Process	GO:0034698	response to gonadotropin	Pcsk5	IEP		Rat	PMID:18502031\|RGD:11556212
Biological Process	GO:0034699	response to luteinizing hormone	Pcsk5	IEP		Rat	PMID:18502031\|RGD:11556212
Biological Process	GO:0006465	signal peptide processing	PCSK5	IDA		Human	PMID:16912035
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	Pcsk5	IEP		Rat	PMID:11181735\|RGD:11556237
Biological Process	GO:0019058	viral life cycle	PCSK5	IEP		Human	PMID:8940009
Biological Process	GO:0019058	viral life cycle	Pcsk5	IDA		Mouse	MGI:MGI:3799615\|PMID:8940009

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.