Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PCSK4
  • Mouse genes Pcsk4
  • Rat genes Pcsk4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pcsk4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PCSK4	IPI	UniProtKB:Q3V140	Human	PMID:11164898
Molecular Function	GO:0005515	protein binding	PCSK4	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Cellular Component	GO:0002080	acrosomal membrane	Pcsk4	IDA		Mouse	PMID:16371590
Cellular Component	GO:0001669	acrosomal vesicle	Pcsk4	IDA		Mouse	MGI:MGI:5784979|PMID:21302280
Biological Process	GO:0007340	acrosome reaction	Pcsk4	IMP	MGI:MGI:2665512	Mouse	PMID:16371590
Biological Process	GO:0007339	binding of sperm to zona pellucida	Pcsk4	IMP	MGI:MGI:2665512	Mouse	PMID:16371590
Biological Process	GO:0009566	fertilization	Pcsk4	IMP		Mouse	MGI:MGI:893981|PMID:9192653
Biological Process	GO:0009566	fertilization	Pcsk4	IDA		Mouse	MGI:MGI:5784979|PMID:21302280
Biological Process	GO:0009566	fertilization	Pcsk4	IMP	MGI:MGI:2665512	Mouse	PMID:16371590
Biological Process	GO:0016485	protein processing	PCSK4	IDA		Human	PMID:16040806
Biological Process	GO:0022414	reproductive process	Pcsk4	IMP		Mouse	MGI:MGI:893981|PMID:9192653
Biological Process	GO:0048240	sperm capacitation	Pcsk4	IDA		Mouse	MGI:MGI:5784979|PMID:21302280
Biological Process	GO:0048240	sperm capacitation	Pcsk4	IMP		Mouse	MGI:MGI:5784984|PMID:19342015
Biological Process	GO:0048240	sperm capacitation	Pcsk4	IMP	MGI:MGI:2665512	Mouse	PMID:16371590

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern