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Pcsk4
Gene Detail
 Symbol
Name
ID
Pcsk4
proprotein convertase subtilisin/kexin type 4
MGI:97514
Synonyms PC4, SPC5
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:80321283-80329498 bp, - strand
From VEGA annotation of GRCm38

  8216 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: proprotein convertase, subtilisin/kexin type
Gene Tree: Pcsk4

Human
homologs
Human Homolog PCSK4, proprotein convertase subtilisin/kexin type 4
NCBI Gene ID 54760
neXtProt AC  NX_Q6UW60
Human Synonyms  PC4, SPC5
Human Chr (Location)  19p13.3; chr19:1481428-1490737 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus results in significantly reduced male fertility, putatively due to impaired fertilization.
 
Interactions
Pcsk4 interacts with 61 markers (Mir29a, Mir29b-1, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process acrosome reaction, binding of sperm to zona pellucida, ...
Component acrosomal membrane, cell
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (17)    Tissues (13)    Images (1)
Theiler Stages: 1, 2, 3, 5, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 10
RT-PCR 7
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(9) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000019 (Evidence)
Ensembl Gene ModelENSMUSG00000020131 (Evidence)
Entrez Gene18551 (Evidence)
UniGene299916
DFCITC1586820, TC1591689
DoTSDT.101143059, DT.526117, DT.91338503
NIA Mouse Gene IndexU032006
EC3.4.21.-
Consensus CDS ProjectCCDS24018.1
International Mouse Knockout Project StatusPcsk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000019 VEGA Gene Model | MGI Sequence Detail 8216 C57BL/6J ±  kb
transcript OTTMUST00000045841 VEGA | MGI Sequence Detail 2539 Not Applicable 
polypeptide OTTMUSP00000020653 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(33) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR023827 Peptidase S8, subtilisin, Asp-active site
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
InterPro IPR002884 Proprotein convertase, P
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000012436 proprotein convertase subtilisin/kexin type 4
References (Earliest) J:27312 Nakayama K, et al., Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression. J Biol Chem. 1992 Mar 25;267(9):5897-900
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-13194, MGI:2143658, MGI:2143954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory