Pcsk4 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pcsk4
proprotein convertase subtilisin/kexin type 4
MGI:97514

15 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcsk4^{tm1b(KOMP)Wtsi}/Pcsk4^{tm1b(KOMP)Wtsi} C57BL/6N-Pcsk4^{tm1b(KOMP)Wtsi}/J	increased circulating sodium level	J:211773
	increased heart weight	J:211773
Pcsk4^tm1Mbi/Pcsk4⁺ involves: 129P2/OlaHsd * C57BL/6J	transmission ratio distortion	J:41503
Pcsk4^tm1Mbi/Pcsk4^tm1Mbi B6.129P2-Pcsk4^tm1Mbi	abnormal acrosome assembly	J:233570
	abnormal acrosome reaction	J:107011
	abnormal proacrosomal vesicle fusion	J:233570
	abnormal sperm capacitation	J:107011
	abnormal sperm head morphology	J:233570
	abnormal sperm physiology	J:233570
	impaired binding of sperm to zona pellucida	J:107011
	impaired fertilization	J:107011
	reduced male fertility	J:107011
Pcsk4^tm1Mbi/Pcsk4^tm1Mbi involves: 129P2/OlaHsd * C57BL/6J	decreased hyperactivated sperm motility	J:41503
	decreased litter size	J:41503
	impaired fertilization	J:41503
	reduced female fertility	J:41503
	reduced male fertility	J:41503
	transmission ratio distortion	J:41503

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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