Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NUCB2
  • Mouse genes Nucb2
  • Rat genes Nucb2
  • Zfish genes nucb2a,nucb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nucb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Nucb2	IDA		Mouse	PMID:10915798
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Nucb2	IDA		Rat	PMID:21653697|RGD:14929204
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Nucb2	IDA		Rat	PMID:21653697|RGD:14929204
Molecular Function	GO:0005515	protein binding	NUCB2	IPI	UniProtKB:P24522	Human	PMID:21988832
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Nucb2	IPI	RGD:621237	Rat	PMID:20649583|RGD:5130976
Cellular Component	GO:0005737	cytoplasm	Nucb2	IDA		Mouse	PMID:10915798
Cellular Component	GO:0005737	cytoplasm	Nucb2	IDA		Rat	PMID:20032201|RGD:9831177
Cellular Component	GO:0005783	endoplasmic reticulum	Nucb2	IDA		Mouse	PMID:10915798
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	NUCB2	IDA		Human	PMID:15308636
Cellular Component	GO:0070062	extracellular exosome	NUCB2	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	NUCB2	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Nucb2	IDA		Rat	PMID:17036007|RGD:9831179
Cellular Component	GO:0005794	Golgi apparatus	NUCB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005797	Golgi medial cisterna	Nucb2	IDA		Rat	PMID:11893086|RGD:633331
Cellular Component	GO:0005640	nuclear outer membrane	Nucb2	IDA		Mouse	PMID:10915798
Cellular Component	GO:0005634	nucleus	Nucb2	IDA		Mouse	PMID:10915798
Biological Process	GO:1901142	insulin metabolic process	Nucb2	IDA		Rat	PMID:21828181|RGD:9831189
Biological Process	GO:0032099	negative regulation of appetite	Nucb2	IMP		Rat	PMID:17036007|RGD:9831179
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Nucb2	IDA		Rat	PMID:22486620|RGD:9831186
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Nucb2	IDA		Rat	PMID:22486620|RGD:9831186
Biological Process	GO:0070093	negative regulation of glucagon secretion	Nucb2	IDA		Rat	PMID:21828181|RGD:9831189
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Nucb2	IDA		Rat	PMID:22486620|RGD:9831186
Biological Process	GO:0046321	positive regulation of fatty acid oxidation	Nucb2	IDA		Rat	PMID:21828181|RGD:9831189
Biological Process	GO:2000845	positive regulation of testosterone secretion	Nucb2	IDA		Rat	PMID:22334726|RGD:9831162
Biological Process	GO:0032094	response to food	nucb2b	IDA		Zfish	PMID:26892993
Biological Process	GO:0032094	response to food	nucb2a	IDA		Zfish	PMID:26892993
Biological Process	GO:0009749	response to glucose	Nucb2	IEP		Rat	PMID:20032201|RGD:9831177
Biological Process	GO:0044752	response to human chorionic gonadotropin	Nucb2	IEP		Rat	PMID:22334726|RGD:9831162
Biological Process	GO:1990680	response to melanocyte-stimulating hormone	Nucb2	IEP		Rat	PMID:17036007|RGD:9831179
Biological Process	GO:0042594	response to starvation	Nucb2	IEP		Rat	PMID:22334726|RGD:9831162
Biological Process	GO:0007264	small GTPase mediated signal transduction	Nucb2	IDA		Rat	PMID:21653697|RGD:14929204

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern